Overview of Modern Pharmaceutical Analysis

Ahuja, Satinder

doi:10.1016/b978-0-12-375680-0.00001-2

Cited by 12 publications

(31 citation statements)

References 1 publication

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“…1 H NMR signals are primarily from the solid polymer matrix while 2 H NMR signals are due to water. Vertical slices, parallel to the tablet axis, and horizontal slices at different heights within the tablets can be acquired, all with a slice thickness of about 0.5 mm, at different times during the water penetration process.…”

Section: Nmr Microimagingmentioning

confidence: 99%

“…This enables studies on drug polymorphism since the weak intermolecular forces found in crystal lattices are absent in amorphous forms. This means that crystalline forms of a drug will have a well-defined spectrum while the amorphous forms will be essentially invisible in the terahertz region [2]. Apart from that, water shows very strong terahertz signals allowing this technique to be used to determine moisture content in pharmaceuticals [19].…”

Section: Terahertz Pulsed Spectroscopy Com-bined With Chemometricsmentioning

confidence: 99%

“…With CP/MAS, the sample is rotated around an axis inclined at a "magic angle" ( = 54°44') to the magnetic field so that line broadening is significantly suppressed and resolution is greatly enhanced [2]. This to a large extent, overcomes the overlapping problem of active ingredient by excipients in a pharmaceutical formulation.…”

Section: Dynamic Nuclear Polarization (Dnp) Enhanced Nmrmentioning

confidence: 99%

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Recent Advances in Solid-State Analysis of Pharmaceuticals

Bukhari¹,

Hwei²,

Jantan³

2015

PHARMSCI

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Current analytical techniques for characterizing solid-state pharmaceuticals include powder x-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, Raman spectroscopy, electron microscopy and nuclear magnetic resonance. Powder x-ray diffraction and differential scanning calorimetry are mainstream techniques but they lack spatial resolution. Scanning electron microscopy and micro-Raman spectroscopy provide good chemical and optical characterization but they are not capable of analysing very small nanoparticles. Transmission electron microscopy and nano-thermal analysis can provide explicit characterization of nanoparticles but they are invasive. Nuclear magnetic resonance offers good spatial resolution but its use is mainly limited by poor sensitivity and high costs. In view of the many challenges posed by existing methods, new and novel techniques are being continually researched and developed to cater to the growing number of solid formulations in the pipeline and in the market. Some of the recent advances attained in the solid-state analysis of pharmaceutical are summarized in this review article.

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Section: Nmr Microimagingmentioning

confidence: 99%

Section: Terahertz Pulsed Spectroscopy Com-bined With Chemometricsmentioning

confidence: 99%

Section: Dynamic Nuclear Polarization (Dnp) Enhanced Nmrmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in Solid-State Analysis of Pharmaceuticals

Bukhari¹,

Hwei²,

Jantan³

2015

PHARMSCI

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“…When a given electroanalytical procedure is going to be used in another laboratory; 6. When measurements will be conducted by another person.…”

mentioning

confidence: 99%

“…All electroanalytical procedures require some type of validation, regardless of whether the method is used for stability, purity, identification, potency, in-process analysis, release or acceptance testing, etc like other analytical methods. Although, currently there are differences in the technical requirements among various regulatory agencies, a guideline entitled "Validation of Analytical Procedures" prepared by the International Conference on Harmonization of Technical Requirements for Registration Pharmaceuticals for Human use (ICH) outlines the parameters that should be considered during the validation exercise [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

The Role of and the Place of Method Validation in Drug Analysis Using Electroanalytical Techniques

Gümüştaş¹,

Özkan²

2014

TOACJ

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Electroanalytical methods are chosen for the sensitive analysis of pharmaceutically active compounds in their dosage forms and biological samples. Electroanalytical method validation is the process used to confirm that the determination procedure employed for a specific test is suitable for its intended use like other analytical methods. Results from electroanalytical method validation can be used to judge the quality, applicability, accuracy, reliability and consistency of analytical results; it is an integral part of any analytical procedure. Also in electroanalytical drug analysis, important decisions are taken which are based on data obtained from real samples. Validation parameters help assure that the electroanalytical methods ensure the correct identity, strength, quality, accurate, precise, selective, robust and sensitive. A well-defined and well-documented validation process provides regulatory agencies with evidence that the system and method suitable for its intended use. Method validation is an essential component of the measures that a laboratory should implement to permit it to produce reliable electroanalytical data.

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Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

Rocheleau¹,

Larouche²,

Salamu³

et al. 2012

Journal of Pharmaceutical Analysis

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Liquid chromatography (LC) is considered by many as a mature technique. Nonetheless, LC technology continues to evolve driven by the need for high-throughput and high-resolution analyses. Over the past several years, small particle size packing materials have been introduced by several column manufacturers to enable fast and efficient LC separations. Several examples of pharmaceutical analyses, including impurity profiling of taxanes and atracurium besylate, in-process testing of peptides in injectable dosage form, using sub-2 μm column technology are presented in this paper, demonstrating some of the capabilities and limitations of the technology.

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Overview of Modern Pharmaceutical Analysis

Cited by 12 publications

References 1 publication

Recent Advances in Solid-State Analysis of Pharmaceuticals

Recent Advances in Solid-State Analysis of Pharmaceuticals

The Role of and the Place of Method Validation in Drug Analysis Using Electroanalytical Techniques

Impurity profiling and in-process testing of drugs for injection by fast liquid chromatography

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