Overview of Polyester Nanosystems for Nasal Administration

Modified Magnesium Hydroxide Nanoparticles Inhibit the Inflammatory Response to Biodegradable Poly(lactide-co-glycolide) Implants

“…The penetration of water rapidly occurs through the amorphous regions and contributes to the degradation of PLGA by hydrolysis of its ester linkages. The ester hydrolysis inevitably produces acidic byproducts which tend to accumulate in the center of polymer matrix and induce autocatalysis leading to a further increase in the rate of hydrolysis and resulting in bulk or heterogeneous erosion of polymer matrix. , At this rate, the aggregated Mg­(OH) 2 particles in PLGA matrix will not sufficiently neutralize the acidic degradation products. The aggregated Mg­(OH) 2 may have accelerated degradation reaction of PLGA by attacking the backbone of contacting polymer rather than dispersedly and uniformly dissociating into Mg 2+ and OH – ions and neutralizing the acidic byproducts.…”