Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

Turrini, Eleonora; Sestili, Piero; Fimognari, Carmela

doi:10.3390/toxins12120747

Cited by 49 publications

(34 citation statements)

References 140 publications

(277 reference statements)

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“…Piperine is an alkaloid found in black pepper (Piper nigrum). It has shown downregulation of P-gp, BCRP, MRPs, and ABC transporter genes (ABCB1, ABCG2, and ABCC1), which may reverse MDR in tumor cells [119][120][121][122]. β-Carotene was also reported to modulate P-gp in resistant cancer cell lines (KB-vin and NCI-H460/MX20) and stimulate the basal ATPase activity in a concentration-dependent manner [101,119].…”

Section: P-glycoproteinmentioning

confidence: 99%

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

et al. 2021

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Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing chemotherapy failure. Natural products are accessible, inexpensive, and less toxic sources of chemotherapeutic agents. Additionally, they have multiple mechanisms of action to inhibit various targets involved in the development of drug resistance. In this review, we have summarized the basic research and clinical applications of natural products as possible inhibitors for drug resistance in cancer. The molecular targets and the mechanisms of action of each natural product are also explained. Diverse drug resistance biomarkers were sensitive to natural products. P-glycoprotein and breast cancer resistance protein can be targeted by a large number of natural products. On the other hand, protein kinase C and topoisomerases were less sensitive to most of the studied natural products. The studies discussed in this review will provide a solid ground for scientists to explore the possible use of natural products in combination anticancer therapies to overcome drug resistance by targeting multiple drug resistance mechanisms.

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Section: P-glycoproteinmentioning

confidence: 99%

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

et al. 2021

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“…Several natural dietary products have anticancer effects [6,7]. Spices are also reported as potential anticancer sources [8][9][10][11][12]. For example, extracts of Indian spices can suppress the proliferation of esophageal cancer cells [9].…”

Section: Introductionmentioning

confidence: 99%

“…For example, extracts of Indian spices can suppress the proliferation of esophageal cancer cells [9]. The "king of spices", pepper or Piper nigrum, also shows anticancer effects [11]. The therapeutic effects of spices can be attributed to their bioactive compounds, including alkaloids, terpenes, flavonoids, phenylpropanoids, and anthocyanins [10].…”

Section: Introductionmentioning

confidence: 99%

Burmannic Acid Inhibits Proliferation and Induces Oxidative Stress Response of Oral Cancer Cells

Liu

Yang

et al. 2021

Antioxidants

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Burmannic acid (BURA) is a new apocarotenoid bioactive compound derived from Indonesian cinnamon; however, its anticancer effect has rarely been investigated in oral cancer cells. In this investigation, the consequences of the antiproliferation of oral cancer cells effected by BURA were evaluated. BURA selectively suppressed cell proliferation of oral cancer cells (Ca9-22 and CAL 27) but showed little cytotoxicity to normal oral cells (HGF-1). In terms of mechanism, BURA perturbed cell cycle distribution, upregulated mitochondrial superoxide, induced mitochondrial depolarization, triggered γH2AX and 8-hydroxy-2-deoxyguanosine DNA damage, and induced apoptosis and caspase 3/8/9 activation in oral cancer cells. Application of N-acetylcysteine confirmed oxidative stress as the critical factor in promoting antiproliferation, apoptosis, and DNA damage in oral cancer cells.

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“…14 Extracts of P. nigrum have also shown anti-cancer activity in breast cancer, Ehrlich carcinoma, colon, cervical, and prostate cancer cells with different mechanisms. [15][16][17] However, effect against pancreatic cancer of P. nigrum and piperine has not yet been reported. Hence, the present study was proposed to investigate the effects of P. nigrum extract (PNE) and piperine on proliferation, migration, and invasion of pancreatic cancer cells.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Inhibition of Piper nigrum and Piperine on Growth, Migration, and Invasion of PANC-1 Human Pancreatic Cancer Cells

Jeong

Ryu

Lee

2021

Natural Product Communications

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Several dietary and medicinal herbs have been shown to be effective in the treatment and prevention of cancer. Although Piper nigrum has been shown to have anti-cancer activities against various cancer cells, its anti-pancreatic cancer properties have not been reported. In the present study, P. nigrum extract (PNE) inhibited proliferation of PANC-1 human pancreatic cancer cells. Flow cytometry showed G0/G1 arrest caused by PNE in PANC-1 cells. In addition, Western blot analysis showed that PNE suppressed the protein levels of cell cycle regulators such as cyclin B1, cyclin D1, survivin, and Forkhead box M1 (FoxM1). These findings suggested that the inhibitory activity of PNE against the growth of PANC-1 cells was correlated with cell cycle arrest and repression of cell cycle regulators. Wound healing and trans-well assays showed that PNE suppressed migration and invasion of PANC-1 cells. Piperine, a major alkaloid of Piper nigrum, was identified as the main component of PNE by HPLC analysis. Piperine also attenuated the cell growth, migration, and invasion of PANC-1 cells, suggesting its contribution to the anti-pancreatic cancer effects of PNE. These results demonstrate that PNE and its major constituent, piperine, have anti-pancreatic cancer properties such as growth-inhibition, anti-migration, and anti-invasion of cancer cells.

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Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

Cited by 49 publications

References 140 publications

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

Targeting Drug Chemo-Resistance in Cancer Using Natural Products

Burmannic Acid Inhibits Proliferation and Induces Oxidative Stress Response of Oral Cancer Cells

In Vitro Inhibition of Piper nigrum and Piperine on Growth, Migration, and Invasion of PANC-1 Human Pancreatic Cancer Cells

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