Overview of the Antioxidant and Anti-Inflammatory Activities of Selected Plant Compounds and Their Metal Ions Complexes

Abstract

Numerous plant compounds and their metal-ion complexes exert antioxidative, anti-inflammatory, anticancer, and other beneficial effects. This review highlights the different bioactivities of flavonoids, chromones, and coumarins and their metal-ions complexes due to different structural characteristics. In addition to insight into the most studied antioxidative properties of these compounds, the first part of the review provides a comprehensive overview of exogenous and endogenous sources of reactive oxygen and nitrogen species, oxidative stress-mediated damages of lipids and proteins, and on protective roles of antioxidant defense systems, including plant-derived antioxidants. Additionally, the review covers the anti-inflammatory and antimicrobial activities of flavonoids, chromones, coumarins and their metal-ion complexes which support its application in medicine, pharmacy, and cosmetology.

New Insights Into Gut-Bacteria-Derived Indole and Its Derivatives in Intestinal and Liver Diseases

“…Recently, as a part of microbiotherapy, indole and its derivates were extensively explored in terms of antifungal, anti-platelet, and antioxidant effects in various diseases ( Mucha et al, 2021 ). Accumulating shreds of evidence have demonstrated that indole and its derivatives derived from the intestine exert a profound effect on the intestinal barrier function and intestinal immunity ( Alexeev et al, 2018 ; Scott et al, 2020 ).…”

“…Recently, as a part of microbiotherapy, indole and its derivates were extensively explored in terms of antifungal, anti-platelet, and antioxidant effects in various diseases (Mucha et al, 2021).…”

(±)-Catechin—A Mass-Spectrometry-Based Exploration Coordination Complex Formation with FeII and FeIII

“…Catechin (Figure 1), a flavan-3-ol, is an extensively investigated flavonoid that commonly occurs in many popular beverages and foods, such as green tea, cocoa, dark chocolate, apples, grapes, and others [34]. Due to its antioxidant properties, catechin shows anti-inflammatory [35,36], and cardio- [35,37] and neuroprotective [35,38] effects. Controversially, catechin was also investigated for possible allelopathic activities.…”

Editorial to the Special Issue: “Synthesis of Organic Ligands and Their Metal Complexes in Medicinal Chemistry”

“…The two review articles in this Special Issue presented an overview of the information available on two important topics [ 6 , 7 ]. The first is a comprehensive up-to-date review focused on natural compounds and their complexes, exhibiting a broad spectrum of pharmacological activities, and the second one deals with research on and the applications of platinum-based drugs.…”

“…The review by Budzisz et al [ 6 ] highlighted the beneficial biological activities of plant compounds and their metal complexes, which are attributable to their different structural characteristics and substitution patterns. The first part of the review provides a comprehensive overview of exogenous and endogenous sources of reactive oxygen and nitrogen species, oxidative stress-mediated damage of lipids and proteins, and the protective roles of antioxidant defense systems, including plant-derived antioxidants.…”