Overview of the Endocannabinoid System and Endocannabinoidome

Davis, Mellar P.

doi:10.1007/978-3-030-89918-9_1

Cited by 3 publications

(2 citation statements)

References 301 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,11 An expanded view of the ECS that includes the endocannabinoids and related molecules, their biosynthetic and metabolic pathways, and the many receptors with which they interact is termed the endocannabinoidome. 12 The Cannabis Plant and Its Components…”

Section: The Endocannabinoid Systemmentioning

confidence: 99%

“…In addition to the CB receptors, endocannabinoids appear to interact with myriad other receptors, including transient receptor potential (TRP) ion channels, peroxisome proliferator‐activated nuclear receptors, and orphan GPCRs 7,11 . An expanded view of the ECS that includes the endocannabinoids and related molecules, their biosynthetic and metabolic pathways, and the many receptors with which they interact is termed the endocannabinoidome 12 …”

Section: The Endocannabinoid Systemmentioning

confidence: 99%

See 1 more Smart Citation

Cannabis Science and Therapeutics: An Overview for Clinicians

Sera,

Hempel‐Sanderoff

2024

The Journal of Clinical Pharma

View full text Add to dashboard Cite

Cannabis‐based therapeutics have garnered increasing attention in recent years as patients seek alternative treatments for various medical conditions. This narrative review provides a comprehensive overview of the science behind the medical use of cannabis, focusing on the medical evidence for commonly treated conditions. In addition, the review addresses the practical considerations of using cannabis as a therapeutic agent, offering insights into dosing strategies, variations in cannabinoid formulation, and individual patient responses. Precautions, adverse consequences, and drug interactions are also discussed, with a focus on patient safety and the potential risks associated with cannabis use.This article is protected by copyright. All rights reserved

show abstract

Section: The Endocannabinoid Systemmentioning

confidence: 99%

Section: The Endocannabinoid Systemmentioning

confidence: 99%

Cannabis Science and Therapeutics: An Overview for Clinicians

Sera,

Hempel‐Sanderoff

2024

The Journal of Clinical Pharma

View full text Add to dashboard Cite

show abstract

Tea Prepared from Dried Cannabis: What Do We Drink?

Maly,

Benes,

Binova

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Besides many other uses, dried Cannabis may be used for “tea” preparation. This study focused on a comprehensive characterization of an aqueous infusion prepared according to a common practice from three fairly different Cannabis cultivars. The transfer of 42 phytocannabinoids and 12 major bioactive compounds (flavonoids) into the infusion was investigated using UHPLC-HRMS/MS. Phytocannabinoid acids were transferred generally in a higher extent compared to their counterparts; in the case of Δ9-THC, it was only in the range of 0.4–1.9% of content in the Cannabis used. A dramatic increase of phytocannabinoids, mainly of the neutral species, occurred when cream was added during steeping, and the transfer of Δ9-THC into “tea” achieved a range of 53–64%. Under such conditions, drinking a 250 mL cup of such tea by a 70 kg person might lead to multiple exceedance of the Acute Reference Dose (ARfD), 1 μg/kg b.w., even in the case when using hemp with a Δ9-THC content below 1% in dry weight for preparation.

show abstract

Polyunsaturated fatty acids and their endocannabinoid-related metabolites activity at human TRPV1 and TRPA1 ion channels expressed in HEK-293 cells

Abate,

Santiago,

Garcia-Bennett

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Polyunsaturated fatty acids (PUFAs), particularly Omega-3 (ω-3) and Omega-6 (ω-6) PUFAs, may exert neuroprotective effects via the endocannabinoid system (ECS) and are promoted as brain health supplements. However, despite their potential role in endocannabinoid biosynthesis, the impact of PUFAs on ion channels such as TRPV1 and TRPA1, which are modulated by endocannabinoids, remains incompletely understood. Furthermore, the potential in vitro actions of ω-6 to ω-3 PUFA combined in the ratios available in supplements remains uncertain. Therefore, the objective of this study is to evaluate the functional activity of individual PUFAs, their combination in a specific ratio, and their endocannabinoid-related derivatives on TRPV1 and TRPA1 ion channels. Methodology: We employed a fluorescent Ca-sensitive dye in HEK-293 Flp-In T-REx cells expressing human TRPV1, TRPA1, or an empty vector to measure changes in intracellular calcium concentration ([Ca2+]i). Results: Capsaicin and certain PUFA derivatives such as DHEA, γ-LEA and AEA stimulate TRPV1 activity directly, whereas EPA, DHA, γ-LA, and their 9:3:1 ratio triggered TRPV1 response via a mechanism dependent on prior exposure to phorbol ester. Similarly, cinnamaldehyde and selected PUFA derivatives such as EPEA, DHEA, γ-LEA, 2-AG, 2-AG ether and AEA triggered TRPA1 response, with EPA, DHA, γ-LA, and the 9:3:1 ratio showing significant effects at higher concentrations. Conclusions: PUFAs alone and their combined form in 9:3:1 ratio stimulate TRPA1 activity, whereas their metabolites trigger both TRPV1 and TRPA1 response. These findings suggest new avenues to explore for research into potential mechanisms underlying the neurological benefits of PUFAs and their metabolites.

show abstract

Overview of the Endocannabinoid System and Endocannabinoidome

Cited by 3 publications

References 301 publications

Cannabis Science and Therapeutics: An Overview for Clinicians

Cannabis Science and Therapeutics: An Overview for Clinicians

Tea Prepared from Dried Cannabis: What Do We Drink?

Polyunsaturated fatty acids and their endocannabinoid-related metabolites activity at human TRPV1 and TRPA1 ion channels expressed in HEK-293 cells

Contact Info

Product

Resources

About