Overview of the Epidemiology of Pancreatic Cancer Focusing on the JACC Study

Qiu, Dongmei; Kurosawa, Michiko; Lin, Yingsong; Inaba, Yutaka; Matsuba, Tsuyoshi; Kikuchi, Shogo; Yagyu, Kiyoko; Motohashi, Yutaka; Tamakoshi, Akiko

doi:10.2188/jea.15.s157

Cited by 54 publications

(50 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accumulated evidence now suggests that coffee consumption is associated with a decreased risk of liver cancer, 39,42 but has no association with pancreatic cancer 43 or bladder cancer. 44 Our findings may therefore serve to end the controversial debate about whether there is a relationship between coffee consumption and the risk of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Naganuma

Kuriyama

Akhter

et al. 2007

Intl Journal of Cancer

View full text Add to dashboard Cite

An inverse association between coffee consumption and the risk of colorectal cancer has been reported in several case-control studies, but results from prospective cohort studies have been inconclusive. We conducted a prospective cohort study among a Japanese population to clarify the association between coffee consumption and the risk of colorectal cancer incidence. We used data from the Miyagi Cohort Study for this analysis. Usable self-administered questionnaires about coffee consumption were returned from 22,836 men and 24,769 women, aged 40-64 years, with no previous history of cancer. We used the Cox proportional-hazard regression model to estimate hazard ratios and 95% confidence intervals. During 11.6 years of follow-up (425,303 person-years), we identified 457 cases of colorectal cancer. Coffee consumption was not associated with the incidence of colorectal, colon or rectal cancer. The multivariate-adjusted hazard ratio (95% confidence interval) of colorectal cancer incidence for 3 or more cups of coffee per day as compared with no consumption was 0.95 (0.65-1.39) for men and women (p for trend 5 0.55), 0.91 (0.56-1.46) for men (p for trend 5 0.53) and 1.16 (0.60-2.23) for women (p for trend 5 0.996). Coffee consumption was also not associated with incidence of either proximal or distal colon cancer. We conclude that coffee consumption is not associated with the incidence risk of colorectal cancer in the general population in Japan. ' 2006 Wiley-Liss, Inc.Key words: coffee; colorectal cancer; incidence; Japan; prospective study Colorectal cancer is one of the most common cancers worldwide. 1,2 In Japan, colorectal cancer ranks second in terms of agestandardized incidence rate among all cancers, and it is increasing rapidly. 3 Therefore, primary prevention of colorectal cancer worldwide, including Japan, is a considerable public health concern.Coffee is considered to be a protective factor against colorectal cancer through activity of its anticarcinogenic constituents, cafestol and kahweol. 4 It may also decrease the risk of colorectal cancer by reducing the excretion of bile acids and neutral sterols into the colon. 5 Some epidemiological studies have examined the relationship between coffee consumption and the risk of colorectal cancer. 6 Sixteen out of 20 case-control studies supported an inverse association between high coffee consumption and colorectal cancer risk. [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] However, the results of those studies may have been affected by selection bias or recall bias due to retrospective assessment of coffee consumption and other lifestyles-related factors after diagnosis of cancer. In contrast, results from prospective cohort studies have been inconclusive. [27][28][29][30][31][32][33][34][35][36] Among 10 such studies, 1 suggested an increasing risk, 27 3 showed an inverse association 29,34,36 and the others observed no association. 28,[30][31][32][33]35 However, as the studies that observed any association had some statistical l...

show abstract

Section: Discussionmentioning

confidence: 99%

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Naganuma

Kuriyama

Akhter

et al. 2007

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Indeed it has increased in African Americans as well as in the Japanese over recent years (Oomi and Amano, 1998;Lin et al, 1998;Stat bite, 2002;Qiu et al, 2005;Luo et al, 2007). The mortality of pancreatic cancer almost equals its incidence and most patients die within 6 months because of late diagnosis and lack of effective therapies (Howard, 1996;Jemal et al, 2006).…”

mentioning

confidence: 99%

BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation

et al. 2008

View full text Add to dashboard Cite

Pancreatic cancer has an abysmal prognosis. Targets for early detection, prevention and therapy are desperately needed. Inflammatory pathways have an important impact on tumour growth and progression. Expression of BLT2 (the second leukotriene B 4 receptor) was investigated by real-time RT -PCR and immunohistochemistry. Cell proliferation was studied after stable transfection with BLT2, after treatment with siRNA and Compound A as an agonist. BLT2 is expressed in all pancreatic cancer cell lines. Results from real-time RT -PCR revealed significant overexpression of BLT2 in malignant intraductal papillary mucinous neoplasias (IPMNs) and pancreatic adenocarcinoma. Intense staining was evident in IPMNs, infiltrating tumour cells and advanced pancreatic intraepithelial neoplasias (PanINs) but not in normal ductal cells. Overexpression of BLT2 as well as stimulation of Colo357, Panc-1 and AsPC1 cells with Compound A caused a significant increase in tumour cell proliferation, an effect reversed after siRNA treatment. This study demonstrates for the first time the expression of BLT2 in the pancreas and overexpression in pancreatic cancers and malignant IPMNs in particular. Upregulation of BLT2 is already evident in precursor lesions (PanINs, IPMNs). Overexpression of this receptor leads to significant growth stimulation. Therefore, we suggest BLT2 as a new target for chemoprevention and therapy for pancreatic cancer.

show abstract

“…Therefore, it is important to clarify the etiology and to identify the risk factors for the prevention of this lethal disease. Although smoking, diabetes, obesity, history of chronic pancreatitis, and perhaps alcohol drinking are considered as risk factors for pancreatic carcinogenesis (Verma, 2005;Qiu et al, 2005;Lu et al, 2006;Pandey et al, 2011), the detailed etiology of this disease is not currently fully understood. Thus far, the development of pancreatic cancer has been mainly attributed to the combination of environmental and genetic factors (Malats, 2001).…”

Section: Introductionmentioning

confidence: 99%

A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer

Lü¹,

Hu²,

Fang³

et al. 2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues that form the pancreas. To investigate whether the tribbles homolog 1 (Drosophila) gene (TRIB1) is associated with pancreatic cancer in the Chinese Han population, we conducted this case-control study and genotyped 3 single nucleotide polymorphisms (rs2980879, rs2980874, and rs2235108) of the TRIB1 gene in 182 patients and 359 normal controls of Chinese Han origin and analyzed their association. The results showed that the rs2980879 TRIB1 gene and pancreatic cancer polymorphism was associated with pancreatic cancer [allele: P = 0.023434, genotype: P = 0.03005; odds ratio (OR) and 95% confidence interval (CI) = 0.727788 (0.552664-0.958404)], whereas the rs2980874 polymorphism had no association with pancreatic cancer [allele: P = 0.749885, genotype: P = 0.699533; OR and 95%CI = 1.041981 (0.809196-1.341734)], and the rs2235108 polymorphism was not associated with the disease [allele: P = 0.629475, genotype: P = 0.547534, OR and 95%CI = 1.128290 (0.690829-1.842770)]. Haplotype analyses and linkage disequilibrium tests were also conducted, and the results showed that these 3 loci are not in the same block. In conclusion, our study indicated that the TRIB1 gene is associated with pancreatic cancer. More studies with larger samples are needed in order to support this finding.

show abstract

Overview of the Epidemiology of Pancreatic Cancer Focusing on the JACC Study

Abstract: The relation between smoking and pancreatic cancer is most consistently described. A further analysis of the relationships between family history, hormonal factors in females, dietary and nutritional factors, obesity, physical activity and pancreatic cancer is necessary.

Cited by 54 publications

References 69 publications

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

Coffee consumption and the risk of colorectal cancer: A prospective cohort study in Japan

BLT2 is expressed in PanINs, IPMNs, pancreatic cancer and stimulates tumour cell proliferation

A case-control study indicates that the TRIB1 gene is associated with pancreatic cancer

Contact Info

Product

Resources

About