Overview of the Epidemiology of Obesity and the Early History of Procedures to Remedy Morbid Obesity

MacDonald, Kenneth G.

doi:10.1001/archsurg.138.4.357

Cited by 47 publications

(37 citation statements)

References 40 publications

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“…A BMI of 35 or more with serious comorbidity or a BMI of 40 or more is considered morbid obesity. 1 The incidence of obesity has increased rapidly during the past 2 decades. This increase had been most dramatic in affluent countries.…”

mentioning

confidence: 99%

A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

Lee²,

Wang³

et al. 2005

Arch Intern Med

107

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mentioning

confidence: 99%

A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

Lee²,

Wang³

et al. 2005

Arch Intern Med

107

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“…A obesidade constitui um grave problema de saúde pública no mundo, e tem sido associada ao risco de hipertensão arterial, doenças cardiovasculares, diabetes tipo 2, doenças da vesícula biliar, alguns tipos de câncer, osteoartrite, apneia do sono e outras desordens [1][2][3][4] . Trata-se de uma enfermidade crônica multifatorial caracterizada por fenômenos sociais, ambientais, fisiológicos e clí-nicos de diversas origens que induzem ao desequilíbrio crônico entre a energia ingerida e o gasto energético.…”

Section: N T R O D U ç ã Ounclassified

Ingestão do cálcio na obesidade de mulheres atendidas pelo Sistema Único de Saúde

Silva

Cabral²,

Vasconcelos

2010

Rev. Nutr.

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“…Many factors, such as obesity, high-fat diet, immobility, insulin insensitivity, and alcohol consumption cause hepatic steatosis. Unfortunately, an estimated 65% of American adults are overweight or obese (MacDonald, 2003). Alcohol consumption is also a well-known risk factor for causing steatosis, and many organ donors are accident victims where alcohol consumption was frequently involved.…”

Section: Introductionmentioning

confidence: 99%

Suramin Decreases Injury and Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts

Rehman

Shi

et al. 2012

J Pharmacol Exp Ther

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Steatotic grafts are excluded for use in partial liver transplantation (LT) because of the increased risk of primary nonfunction. This study investigated the effects of suramin, a polysulfonated naphthylurea, on the outcome of steatotic partial LT. Rat livers were harvested after acute ethanol treatment (6 g/kg, intragastric administration), reduced in size to ∼1/3, and transplanted. Serum alanine aminotransferase (ALT) and total bilirubin levels as well as hepatic necrosis and apoptosis were significantly higher after transplantation of fatty partial grafts (FPG) than lean partial grafts (LPG). Suramin (5 mg/ kg, i.p.) decreased ALT by ∼60%, hyperbilirubinemia by 75%, necrosis by 83%, and apoptosis by 70% after FPG transplantation. Hepatic cellular 5-bromo-29-deoxyuridine (BrdU) incorporation increased to 28% in LPG but was only 2% in FPG at 48 hours, and the mitotic index increased to 7% in LPG but was only 0.2% in FPG, indicating suppressed regeneration in FPG. Suramin increased BrdU incorporation and the mitotic index to 43% and 9%, respectively, in FPG. All FPG recipients died within 5 days. Suramin recovered survival of FPG to 62%. Tumor necrosis factor-a (TNF-a) mRNA was 2.2-fold higher in FPG than in LPG and was associated with activation of caspase-8 and caspase-3 in FPG. Suramin decreased TNF-a and caspase activation in FPG. Transforming growth factor-b (TGF-b), phospho-Smad2/3 and p21Cip1 were significantly higher in FPG than in LPG and suramin blocked TGF-b formation and its down-stream signaling pathway. Taken together, suramin improves the outcome of FPG transplantation, most likely by inhibition of TNF-a and TGF-b formation.

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Overview of the Epidemiology of Obesity and the Early History of Procedures to Remedy Morbid Obesity

Cited by 47 publications

References 40 publications

A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

A Case-Control Study of Association of Helicobacter pylori Infection With Morbid Obesity in Taiwan

Ingestão do cálcio na obesidade de mulheres atendidas pelo Sistema Único de Saúde

Suramin Decreases Injury and Improves Regeneration of Ethanol-Induced Steatotic Partial Liver Grafts

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