Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

Carneiro, Marcos Rodrigo Beltrão; Sallum, Lóide O.; Martins, José Luís Rodrigues; Peixoto, Josana de Castro; Napolitano, Hamilton B.; Rosseto, Renato

doi:10.3390/molecules28031190

Cited by 12 publications

(3 citation statements)

References 148 publications

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“…A different study observed similar trend for these haematological parameters with a normal WBC in curative and suppressive tests on the antioxidant and antimalarial activity of the ethanol stem bark extract of Terminalia macroptera in P. berghei-infected mice [44]. The haematinic properties of the extract in this study may be due to the presence of avonoid compounds that have been reported to increase iron absorption and deposition in tissues while reducing iron excretion [45]. In addition, many antimalarial herbal preparations may exert their anti-infective activity not only by affecting the parasite directly but may also stimulate the defensive system of the host through many other mechanisms [46].…”

Section: Discussionsupporting

confidence: 81%

Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei

ADEYEMI,

ONIYE,

REKWORT

et al. 2024

Preprint

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Background Plasmodium parasite that causes malaria has developed resistance to most antimalarial medications and this has prompted research on natural products. The plant, Justicia secunda, is domesticated in the tropical region of Africa, and is used for the treatment of anaemia and other debilities. We evaluated the antiplasmodial and immunomodulatory activity of ethanol leaf extract of J. secunda in mice experimentally infected with Plasmodium berghei. Result Ethanol leaf extract of Justicia secunda contains steroids, tannins, flavonoids, terpenoids, phenols, glycosides and carbohydrate as well as thirty (30) compounds with numerous pharmacological activities. The LD50 was above 5,000mg/kg with no mortality. A dose-dependent percentage suppression of P. berghei was observed in the curative test for the three doses respectively (53.13%, 60.71%, 71.21%). The suppressive test for ethanol leaf extract of J. secunda also showed a similar trend (52.2%, 62.16%, 75.18%). The ethanol leaf extract of J. secunda effectively prevented anaemia, reduced the level of ALT enzyme and also increased the level of TNF-α and IL-10 in the plasma of P. berghei-infected mice. It also significantly reduced the oxidative stress and vascular congestion in the liver of mice infected with P. berghei. Conclusion This study revealed that ethanol leaf extract of J. secunda could be utilized to treat infection caused by Plasmodium parasite and also ameliorate the pathogenesis of the disease.

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Section: Discussionsupporting

confidence: 81%

Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei

ADEYEMI,

ONIYE,

REKWORT

et al. 2024

Preprint

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“…Te genus Justicia, with over 600 species of scandent perennial herbs and shrubs, represents the largest genus in the family Acanthaceae [1]. Its species are usually found in warm and temperate regions of the world including Africa, Asia, and America.…”

Section: Introductionmentioning

confidence: 99%

A Study on Justicia flava (Forssk.) Vahl.: Pharmacognostic Characterization and Antiplasmodial and Anti-Inflammatory Properties of the Leaves

Asante-Kwatia,

Baah,

Forkuo

et al. 2023

The Scientific World Journal

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Justiciaflava (Acanthaceae) is utilized in folk medicine for treating malaria, inflammatory conditions, and respiratory infections. In this study, the antiplasmodial and anti-inflammatory activities of the 70% hydroalcoholic leaf extract of J. flava (JFE) were investigated. The antiplasmodial activity was assessed by the suppressive test and Rane’s curative test. The carrageenan-induced paw oedema assay in chicks was used to assess the anti-inflammatory activity. In Rane’s curative test, JFE significantly suppressed the parasitaemia level ( p < 0.0001) by 56.85%, 63.85%, and 77.85% at 30, 100, and 300 mg·kg−1, respectively. The highest suppression of parasitaemia in the suppressive test was 51.31% at 300 mg·kg−1. The extract prolonged the survival time of infected mice significantly and prevented weight loss and hypothermia which are cardinal signs of P. berghei-induced infection. JFE inhibited foot oedema in chicks with a maximum percentage inhibition of 54.00 ± 5.20%. Pharmacognostic characterization of J. flava revealed it to have simple, petiolate, oppositely arranged leaves which are broadly lanceolate in shape with entire to slightly crenate margins. Microscopy of the leaf showed wavy-walled epidermal cells, diallelocytic stomata, abundant clothing and secretory trichomes, pitted vessels, collateral conjoint vascular bundles, cystoliths, and prismatic calcium oxalate crystals. Flavonoids, tannins, phytosterols, triterpenoids, coumarins, alkaloids, and saponins were detected in the plant. This study has provided important parameters for the correct identification of J. flava and given the scientific credence to its antimalarial and anti-inflammatory effects in traditional medicine. J. flava is a potential source of new antimalarial and anti-inflammatory compounds.

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“…20 Several biologically active chemical compounds, such as apigenin, naringenin, phytol, etc., were also identified in the plant of the same genus, Justicia gendarussa Burm. 21 J. schimperiana demonstrated antibacterial, 18,22 antidiarrheal, 13 antimalarial, 15,23,24 anti-diabetic, 25 hepatoprotective, 26 anti-asthmatic, [27][28][29] wound healing, 17 antifungal, 14,22,30 and anti-rabies 16,31 activities.…”

Section: Introductionmentioning

confidence: 99%

Acute and Sub-Acute Toxicity Evaluation of the Crude Methanolic Extract of Justicia schimperiana Leaf in Wistar Albino Rats

Jegnie,

Abula,

Woldekidan

et al. 2023

JEP

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This study evaluates the acute and sub-acute toxicity of 80% methanolic extracts of the leaves of Justicia schimperiana in Wistar albino rat models. Methods: Dried powdered leaves of Justicia schimperiana were macerated in 80% methanol. The experiment was conducted in accordance with the Organization for Economic Co-operation and Development guideline 423 for acute and 407 for sub-acute toxicity testing. A single dose of 5000 mg/kg extract was orally administered to three female rats for the acute toxicity study. The plant extract was administered orally for 28 days in daily dosages of 250, 500, and 1000 mg/kg for the sub-acute study. Animals in a control group were given distilled water. A total of 40 rats (5 rats/group/sex) were used for the sub-acute toxicity testing. Daily food intake and weekly body weight measurements were done. The rats were sacrificed at the end of the 28-day treatment period for hematological, biochemical, and histopathological tests. One-way analysis of variance and Kruskal-Wallis tests were employed for the analysis. Results: The single-dose oral administration of the plant resulted in no deaths or serious morbidity. The median lethal dose was >5000 mg/kg. The 28-day oral treatment of the plant extract had no significant effect on general behavior, food intake, organ weight, biochemical parameters, or the majority of the hematological markers, with the exception of the decrease in hemoglobin and hematocrit in the 1000 mg/kg extract-treated groups compared to the controls. Both sexes experienced significant weight increases at all dosage levels. With the exception of minor alterations in a few of the organs, no significant histological change was identified. Conclusion: It is concluded that the single-dose and repeated-dose 28-day oral administration of the methanolic leaf extract of Justicia schimperiana is relatively safe.

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Overview of the Justicia Genus: Insights into Its Chemical Diversity and Biological Potential

Cited by 12 publications

References 148 publications

Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei

Pharmacological Efficacy of Ethanol Leaf Extract of Justicia secunda in Swiss Albino Mice Experimentally Infected with Plasmodium berghei

A Study on Justicia flava (Forssk.) Vahl.: Pharmacognostic Characterization and Antiplasmodial and Anti-Inflammatory Properties of the Leaves

Acute and Sub-Acute Toxicity Evaluation of the Crude Methanolic Extract of Justicia schimperiana Leaf in Wistar Albino Rats

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