Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

Han, Ji Won; Kim, Tae Hui; Kwak, Kyung Phil; Kim, Kayoung; Kim, Bong-Jo; Kim, Shin Gyeom; Kim, Jeong Lan; Kim, Tae Hyun; Moon, Seok Woo; Park, Jae Young; Park, Joon Hyuk; Byun, Seonjeong; Suh, Seung Wan; Seo, Ji Young; So, Yoonseop; Ryu, Seung Ho; Youn, Jong Chul; Lee, Kyoung Hwan; Lee, Dong Hoon; Lee, Dong Woo; Lee, Seok Bum; Lee, Jung Jae; Lee, Ju Ri; Jeong, Hyeon Jang; Jeong, Hyun Chul; Jhoo, Jin Hyeong; Han, Kyou‐Sup; Hong, Jong Woo; Kim, Ki Woong

doi:10.30773/pi.2018.06.02

Cited by 105 publications

(115 citation statements)

References 44 publications

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“…The KLOSCAD is an ongoing, nationwide, population-based, prospective cohort study on cognitive aging and dementia in the elderly. 29 In the KLOSCAD, 6,818 community-dwelling Koreans, aged 60 years or older, who were randomly sampled from 30 villages or towns across South Korea, completed the baseline assessment, which was conducted from November 2010 through October 2012. Among them, 505 cognitively normal participants without hypertension or with controlled hypertension who were enrolled from Yongin, Gyeonggi-do were included in the current study (Table 1).…”

Section: Participantsmentioning

confidence: 99%

Association of Low Blood Pressure with White Matter Hyperintensities in Elderly Individuals with Controlled Hypertension

et al. 2020

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Background and Purpose Both hypertension and hypotension increase cerebral white matter hyperintensities. However, the effects of hypotension in individuals with treated hypertension are unknown. We analyzed the association of low blood pressure with the location and amount of white matter hyperintensities between elderly individuals with controlled hypertension and those without hypertension.Methods We enrolled 505 community-dwelling, cognitively normal elderly individuals from the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia. We measured blood pressure three times in a sitting position using a mercury sphygmomanometer and defined low systolic and diastolic blood pressure as ≤110 and ≤60 mm Hg, respectively. We segmented and quantified the periventricular and deep white matter hyperintensities from 3.0 Tesla fluid-attenuated inversion recovery magnetic resonance images.Results Low systolic blood pressure was independently associated with larger volume of periventricular white matter hyperintensity (P=0.049). The interaction between low systolic blood pressure and hypertension was observed on the volume of periventricular white matter hyperintensity (P=0.005). Low systolic blood pressure was associated with the volume of periventricular white matter hyperintensity in individuals with controlled hypertension (F1,248=6.750, P=0.010), but not in those without hypertension (P=0.380). Low diastolic blood pressure was not associated with the volumes of white matter hyperintensities regardless of presence of controlled hypertension.Conclusions Low systolic blood pressure seems to be associated with larger volume of periventricular white matter hyperintensity in the individuals with a historyof hypertension but not in those without hypertension.

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Section: Participantsmentioning

confidence: 99%

Association of Low Blood Pressure with White Matter Hyperintensities in Elderly Individuals with Controlled Hypertension

et al. 2020

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“…South Korea became an aged society in 2017, when more than 14% of the population was aged 65 years or older, and it is projected to become a postaged society by 2025, when 20% of the population will be older than 65 years. 51 The number of dementia patients is increasing rapidly along with this unprecedented rate of population aging in South Korea. We aim to address this situation by developing a multidomain intervention program that will be easy to disseminate to large numbers of older people nationwide.…”

Section: Discussionmentioning

confidence: 99%

South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial

et al. 2020

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Background and Purpose The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. We have developed programs of the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), which consists of a facility-based multidomain intervention (FMI) program and a home-based multidomain intervention (HMI) program suitable for elderly Koreans. We aim to determine the feasibility of the SUPERBRAIN programs before a large-scale randomized controlled trial. Methods We will recruit 150 participants among those without dementia aged 60-79 years with at least 1 modifiable dementia risk factor. They will be randomly assigned in a 1:1:1 ratio to the FMI, HMI, and the waiting-list control arm. The 6-month multidomain intervention consists of management of metabolic and vascular risk factors, cognitive training and social activity, physical exercise, nutritional guidance, and motivational enhancement programs. The primary outcomes are adherence and retention rates and changes in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to the study end. The main secondary outcomes are disability, depressive symptoms, quality of life, vascular risk factors, physical performance, nutritional assessment, and motivation questionnaire. There will be an exploratory evaluation of neurotrophic, neurodegeneration, and neuroinflammation factors, microbiome, telomere length, electroencephalography, and neuroimaging measures. Conclusions The results obtained will provide information on the applicability of these multidomain intervention programs to at-risk elderly people.

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“…We recruited 38 DLB patients from the dementia clinic of Seoul National University Bundang Hospital. We enrolled 38 age- and sex-matched cognitively normal controls from the participants of the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD), which is a nationwide population-based prospective cohort study on cognitive aging and dementia launched in 2009 [21]. The characteristics of the subjects are summarized in Table 1.…”

Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging Texture of Medial Pulvinar in Dementia with Lewy Bodies

Tak

Lee

Choi³

et al. 2020

Dement Geriatr Cogn Disord

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Introduction: Executive dysfunction is common in dementia with Lewy bodies (DLB). The pulvinar nucleus plays a role in executive control and synchronizes with cortical regions in the salience network that are vulnerable to Lewy pathology. Objective: We investigated the pulvinar subregions in patients with mild DLB and their associations with executive function. Methods: The sample consisted of 38 DLB patients and 38 age-and sex-matched normal controls. We evaluated cognitive function using the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet. We obtained four pulvinar nuclei using preprocessed T1-weighted magnetic resonance images. We compared volumes and textures of the DLB patients and the normal controls for each nucleus. We used a linear regression to determine the association of textures and neuropsychological test scores. Results: The DLB patients showed comparable volumes to the normal controls in all pulvinar nuclei. However, the DLB patients showed different texture of the left medial pulvinar (PuM) from the normal controls. The entropy, contrast, and cluster shade were lower but autocorrelation of left PuM was higher in the DLB patients compared to the normal controls. These texture features of the left PuM were associated with the set-shifting performance measured by the Trail Making Test. Conclusions: In DLB, the left PuM may be altered from early stage, which may contribute to the development of executive dysfunction.

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Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

Cited by 105 publications

References 44 publications

Association of Low Blood Pressure with White Matter Hyperintensities in Elderly Individuals with Controlled Hypertension

Association of Low Blood Pressure with White Matter Hyperintensities in Elderly Individuals with Controlled Hypertension

South Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial

Magnetic Resonance Imaging Texture of Medial Pulvinar in Dementia with Lewy Bodies

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