Overview of the synergistic use of radiotherapy and immunotherapy in cancer treatment: current challenges and scopes of improvement

Colciago, Riccardo Ray; Fischetti, Irene; Giandini, Carlotta; Rocca, Eliana La; T., Tiziana Rancati; Mateo, Alicia Rejas; Colombo, Mario P.; Lozza, Laura; Chiodoni, Claudia; Jachetti, Elena; Santis, Maria Carmen De

doi:10.1080/14737140.2023.2173175

Cited by 15 publications

(5 citation statements)

References 93 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IRT involves the synergistic application of RT and immunotherapy regimens, which are not necessarily synchronized [ 29 ]. RT includes stereotactic ablative RT (SABR), moderate hypofractionated RT (mHFRT), or conventionally fractionated RT (CFRT).…”

Section: Discussionmentioning

confidence: 99%

Global research landscape and trends of cancer radiotherapy plus immunotherapy: A bibliometric analysis

Liu,

Jiang,

et al. 2024

Heliyon

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Global research landscape and trends of cancer radiotherapy plus immunotherapy: A bibliometric analysis

Liu,

Jiang,

et al. 2024

Heliyon

View full text Add to dashboard Cite

“…According to [19], immunotherapy is a field of study that focuses on improving the body's capacity to recognize and eliminate foreign cells or dangers. The main focus of immunotherapy is the advancement of knowledge in immunology, a field concerned with studying the immune system [20]. The increased understanding of how immune defenses might be used to treat various disorders has spurred interest in the topic.…”

Section: Methodsmentioning

confidence: 99%

Immunotherapy Influence On Human Body: Glycan Engineering Antibody-Based Cancer Treatments

2024

J COMM MED PUB HEALTH REP

View full text Add to dashboard Cite

Analysis of cells, soluble substances, and related tissues and cells that cooperate to extend life continues to awaken researchers' curiosity.Because of its incredible complexity, the immune system is opaque to the outer world. Scholars strive to comprehend the several facets that combine to give a comprehensive picture of the system's operation. Thus, various tactics have been acknowledged for their role in the development of immunotherapy, including genetic approaches, animal models, specialized tools, monoclonal antibodies, and immunological techniques. Much research has been done to understand the effects of immunotherapy on human bodies to develop a range of treatments.Understanding the various aspects of immunotherapy's role in health, sickness management, and aging has been made possible by the discoveries about cell subsets, membrane molecules, and cell functions. A thorough grasp of the systems and elements that provide an enabling platform for welfare management has resulted from a focus on the aspects of immunotherapy. Welfare management falls under the purview of developing various immunotherapies, which have served as the cornerstone for sustainable welfare management. The impact of the application of immunotherapy has been explored in the context of efficient service delivery, ranging from cancer to tumor management. The effect on human bodies has been clarified by developing several immunotherapies, such as adopting infections, adopting them prophylactically, and using monoclonal antibodies and recombinant proteins. Investing in immunotherapy has, therefore, been responsible for the change in how we treat many diseases. The necessity to investigate immunotherapy and its impact on human bodies has led to the development of an enabling platform for examining and adequately managing diseases.

show abstract

“…In this ever-evolving clinical scenario, it is crucial to determine the role of adjuvant radiotherapy (RT) and its possible interaction with these novel drugs. To date, experience gained in various oncological settings suggests a favorable toxicity pro le [12]. However, speci c evidence regarding breast cancer is still scarce.…”

Section: Introductionmentioning

confidence: 99%

Safety of pembrolizumab with concurrent radiotherapy in early stage breast cancer: preliminary prospective real-world evidence

Colciago,

Presti,

Giandini

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

INTRODUCTION Data on the feasibility and potential synergy of concomitant immunotherapy with radiation therapy (RT) is still scarce for early breast cancer (BC). We aimed to assess the safety profile of adjuvant pembrolizumab with concomitant radiotherapy (RT) in breast cancer patients. MATERIAL AND METHODS: We prospectively collected data from ten patients with triple-negative breast cancer treated with neoadjuvant chemotherapy with pembrolizumab (as per Keynote-522 criteria) followed by surgery and at least 1 cycle of adjuvant pembrolizumab with concomitant RT. A total dose of 40.05 Gy delivered in 15 fractions was prescribed to the breast or chest wall, with regional nodes and tumor bed boost administered as clinically indicated. The study endpoint was to assess acute toxicity according to the Radiation Therapy Oncology Group scale, and to report the rate of discontinuation of RT and/or pembrolizumab. RESULTS A median of 8 (range 4 – 9) cycles of neoadjuvant Pembrolizumab were prescribed. Before RT, patients received a median of 3 (range 2 – 4) cycles of adjuvant Pembrolizumab. Severe acute toxicity occurred in 2 patients. Specifically, G4 myositis led to permanent discontinuation of adjuvant pembrolizumab in one case, whereas G3 electrolyte imbalance caused definitive RT interruption and temporary discontinuation of adjuvant pembrolizumab in the second case. Among the remaining 8 patients, only 2 patients experienced G2 skin erythema with no treatment discontinuation. CONCLUSIONS The combination of adjuvant pembrolizumab with concurrent radiotherapy proved feasible in the real world, as toxicity was minimal and consistent with existing literature.

show abstract

Overview of the synergistic use of radiotherapy and immunotherapy in cancer treatment: current challenges and scopes of improvement

Cited by 15 publications

References 93 publications

Global research landscape and trends of cancer radiotherapy plus immunotherapy: A bibliometric analysis

Global research landscape and trends of cancer radiotherapy plus immunotherapy: A bibliometric analysis

Immunotherapy Influence On Human Body: Glycan Engineering Antibody-Based Cancer Treatments

Safety of pembrolizumab with concurrent radiotherapy in early stage breast cancer: preliminary prospective real-world evidence

Contact Info

Product

Resources

About