Overview of the synthetic routes of 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamides-1,1-dioxides (oxicams) and their analogues

Recent Advances in Synthesis and Medicinal Evaluation of 1,2‐Benzothiazine Analogues

“…The benzothiazine motifs can be of 3 different types such as 1,2-benzothiazine, 1,3-benzothiazine, and 1,4-benzothiazine based upon the relative position of N and S atoms. Applications of 1,2-benzothiazine, [17][18] 1,3-benzothiazine, [19][20] and 1,4-benzothiazine [21][22] is quite palatial in medicinal as well as synthetic fields of chemistry. The remarkable features of these heterocycles can be witnessed by their large number of publications (1782) and citations (11592) in recent times.…”

“…There have been a vast discussion on the synthesis of 1,2benzothiazine analogues, [17][18][93][94] but this review concerned about the medicinal and synthetic progress reported till date. Here we discuss, pharmacologically acknowledged compounds of 1,2-benzothiazine derivatives and their corresponding synthetic routes along with their data of biological activity.…”