Abstract-A system to monitor the concentrations of trace chemicals in cabin atmosphere is one of the most critical components in long-duration human flight missions.12 The Vehicle Cabin Atmosphere Monitor (VCAM) is a miniature gas chromatograph mass spectrometer system to be used to detect and quantify trace chemicals in the International Space Station.We developed an autonomous computational process to quantify trace chemicals for use in VCAM. The process involves the design of a measured signal quantification scheme, the construction of concentration curves (i.e. the relationship between concentration and ion count measured by VCAM), the decision rule of applying high-or low-gain concentration curves, and the detection of saturation, low-signals, and outliers. When the developed quantification process is applied, the average errors of concentration for most of trace chemicals are found to be between 14% and 66%.