Overview of the World Congress on cord blood and innovative approaches to the treatment of sickle-cell anemia in Monaco on 24-27th october 2013

Current status and perspectives of cryostorage and clinical application of the umbilical cord blood in Ukraine and in the world

“…• Lower risk of the «graft-versus-host» disease even in case of incomplete immunological compatibility [1,4,[12][13][14][15]; • Higher proliferative potential, that is important for regenerative therapy [13]; • Lower risk of infection for the recipient, in particular cytomegalovirus infection [2]; •…”

“…The immediate availability of a transplant due to the large number of births in the world (about 130 million / year) [13,14]; • Noninvasiveness of procedures of cord blood collection [1,4,[12][13][14][15]; • Ethics [1,13,15]. The disadvantages of cord blood transplants include longer period of engraftment and insufficient number of cells in the graft to restore hematopoiesis after myeloablative therapy in adults [1,15]. However, modern biotechnologies enable to overcome these limitations, implementation of methods of transplantation of two umbilical cord blood samples into clinical practice make possible wide application of this material in recipients weighing more than 50 kg [1,11].…”

“…The disadvantages of cord blood transplants include longer period of engraftment and insufficient number of cells in the graft to restore hematopoiesis after myeloablative therapy in adults [1,15]. However, modern biotechnologies enable to overcome these limitations, implementation of methods of transplantation of two umbilical cord blood samples into clinical practice make possible wide application of this material in recipients weighing more than 50 kg [1,11]. Thus, according to EUROCORD, transplantation of two umbilical cord blood samples was found to be more effective compared to one sample transplant although this method is more expensive [1,11].…”

“…However, modern biotechnologies enable to overcome these limitations, implementation of methods of transplantation of two umbilical cord blood samples into clinical practice make possible wide application of this material in recipients weighing more than 50 kg [1,11]. Thus, according to EUROCORD, transplantation of two umbilical cord blood samples was found to be more effective compared to one sample transplant although this method is more expensive [1,11]. Due to application of two samples, the number of cord blood transplants performed in adults to date overexceeds this index in children [1,11].…”

“…Thus, according to EUROCORD, transplantation of two umbilical cord blood samples was found to be more effective compared to one sample transplant although this method is more expensive [1,11]. Due to application of two samples, the number of cord blood transplants performed in adults to date overexceeds this index in children [1,11]. If from 1988 to 2014, 53 % of cord blood Umbilical cord blood is a part of fetus blood that remains after birth in the vessels of the umbilical cord and placenta, that for a long time were regarded as medical waste and discarded [14,15].…”