High intensity focused ultrasound (HIFU) because of its unique noninvasive capability has received the increasingly widespread interests. With this technique, sufficiently high ultrasound energy is brought into a tight focus, generating the well-controlled tissue necrosis while leaving the surrounding or overlying tissues unharmed. So far, it has been used in clinics for the treatment of liver, kidney, breast, bone, prostate and pancreas cancer and uterine fibroids with great success. Although HIFU therapy is promising and has become more and more popular for cancer therapy in recent years, clinical adoption of this technique still faces some challenges,