Overview on major lipid peroxidation bioactive factor 4-hydroxynonenal as pluripotent growth-regulating factor

Abstract

The reactive aldehyde 4-hydroxynonenal (HNE) is major bioactive marker of lipid peroxidation generated under oxidative stress from polyunsaturated fatty acids. Biomedical significance of HNE was first revealed in pathogenesis of various degenerative and malignant diseases. Thus, HNE was considered for decades only as cytotoxic molecule, "second toxic messenger of free radicals" responsible for numerous undesirable consequences of oxidative stress. However, the increase of knowledge on physiology of redox signaling revealed also desirable, physiological roles of HNE, especially in the field of cellular signaling pathways regulating proliferation, differentiation, and apoptosis. These pluripotent effects of HNE can be explained by its concentration-dependent interactions with the cytokine networks and complex cellular antioxidant systems also showing cell and tissue specificities. Therefore, this paper gives a comprehensive, yet short overview on HNE as pluripotent growth-regulating factor.

Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts

“…These chemical compounds act not only in abnormal conditions but, likewise, in physiological conditions, as in our study. This is in accordance with literature data which demonstrate that 4-HNE has a stimulating effect on cell growth not only in malignant cells but also in mesenchymal cells, such as bone [51]. It was also shown that 4-HNE is one of the very important products of n-6 polyunsaturated fatty acid peroxidation.…”

Lipid mediators involved in the oxidative stress and antioxidant defence of human lung cancer cells

“…As a consequence, the oxidative modifications of cellular components, including phospholipids, DNA and proteins, are accumulated in tumour cells causing additional disturbances in their metabolism [2]. Several studies have shown that the lipid peroxidation products such as reactive aldehydes are involved in the intracellular signalling pathways and activation of transcription factors in cancer cells [3].…”

Analyzing Nootropic Effect of <i>Phyllanthus reticulatus</i> Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease

“…Polyunsaturated fatty acids (PUFAs) of the brain membrane phospholipids are particularly susceptible to free radical attack because their double bonds permit easy withdrawal of hydrogen ions [21]. Oxidation of PUFAs, principally arachidonic and docosahexaenoic convey lipid peroxidation in AD [22] by generating alde-hydes most importantly 4-hydroxynonenal (HNE), a highly reactive cytotoxic agent able to inhibit glycolysis, nucleic acid and protein synthesis and degrading proteins [23]. Oxidation of DNA can generate strand breaks, sister chromatid exchange, DNA-protein crosslinking and base alterations [24].…”