Overview on the antiviral activities and mechanisms of marine polysaccharides from seaweeds

Shi, Qimin; Wang, Anjian; Lu, Zhonghua; Qin, Chunjun; Hu, Jing; Yin, Jian

doi:10.1016/j.carres.2017.10.020

Cited by 166 publications

(119 citation statements)

References 93 publications

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“…It has also been reported that the administration of fucoidan derived from Wakame seaweed to mice enhanced NK activity in herpes simplex virus type 1‐infected mice (Hayashi, Nakano, Hashimoto, Kanekiyo, & Hayashi, ). Although it is unclear which component contributed to the increase in the number of NK cells in this study, immunity was activated not only by fucoidan but also by other polysaccharides derived from seaweed (Okolie, Ck Rajendran, Udenigwe, Aryee, & Mason, ; Shi et al, ), and it is possible that either of these was involved in the increase of NK cells. A decrease in neutrophils was observed in Experiment 3.…”

Section: Discussionmentioning

confidence: 71%

Addition of Wakame seaweed (Undaria pinnatifida) stalk to animal feed enhances immune response and improves intestinal microflora in pigs

Shimazu

Borjigin

Katoh

et al. 2019

Animal Science Journal

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This study was conducted to evaluate the effects of supplementation of Wakame seaweed stalks on the immunity and intestinal microflora of pigs. Three separate experiments were performed: Relatively young (start at 20–30 kg; Experiments 1 and 2) and fattening period (70 kg; Experiment 3). All pigs (including the control group) were fed the same commercial feed, free from antibiotic additives, but in the feed for the treatment groups, 1% seaweed powder was added. There were no group differences observed in daily weight gain and feed intake in Experiments 1 and 2 between groups; however, daily weight gain was significantly higher in the treatment group compared to the control group in Experiment 3. The percentage of peripheral blood natural killer cells of the treatment group was significantly higher than that of the control group in all experiments. Although addition of seaweed changed the gene expression of cytokine and toll‐like receptors of the small intestinal Peyer's patches slightly, seaweed seems to alter intestinal microflora preferentially, for instance, there was an increase in Lactobacillus and a decrease of Escherichia coli observed. These results suggest that Wakame seaweed can be used as supplement for pig feed to improve the gut health and immunity of pigs.

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Section: Discussionmentioning

confidence: 71%

Addition of Wakame seaweed (Undaria pinnatifida) stalk to animal feed enhances immune response and improves intestinal microflora in pigs

Shimazu

Borjigin

Katoh

et al. 2019

Animal Science Journal

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“…The major repeating disaccharide units are formed through an l-rhamnose 3-sulfated linked to a d-guluronic acid residue (ulvanobiuronic acid unit A), l-iduronic acid residue (ulvanobiuronic acid unit B), d-xylose 4-sulfated residue (ulvabiose unit A), and d-xylose 4-sulfated residue (ulvabiose unit B). Generally, the molecular weights of ulvan vary from 189 to 8200 kD [16,25,28,[31][32][33].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial and Antiviral Activities of Local Thai Green Macroalgae Crude Extracts in Pacific White Shrimp (Litopenaeus vannamei)

et al. 2020

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Macroalgae are potentially excellent sources of bioactive secondary metabolites useful for the development of new functional ingredients. This study was conducted to determine the antimicrobial efficacy of the hot water crude extracts (HWCEs) of three species of local Thai green macroalgae Ulva intestinalis (Ui), U. rigida (Ur), and Caulopa lentillifera (Cl) and a commercial ulvan from U. armoricana (Ua). Chemical analysis indicated that the HWCE of Ur showed the highest sulfate content (13.9% ± 0.4%), while that of Ua contained the highest uronic acid and carbohydrate contents (41.47% ± 4.98% and 64.03% ± 2.75%, respectively), which were higher than those of Ur (32.75% ± 1.53% and 51.02% ± 3.72%). Structural analysis of these extracts by Fourier-transform infrared (FTIR) spectroscopy revealed that these HWCEs are complex with a signal at 1250 cm−1 corresponding to S=O stretching vibrations, while the signals at 850 cm−1 were attributed to the C–O–S bending vibration of the sulfate ester in the axial position. These HWCEs showed the growth suppression against some pathogenic Vibrio spp. Interestingly, the HWCEs from Ui at concentrations of 5 and 10 mg/mL completely inhibited white spot syndrome virus (WSSV) in shrimp injected with HWCE–WSSV preincubated solutions. This inhibitory effect was further confirmed by the reduction in viral loads and histopathology of surviving and moribund shrimp.

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“…However, the treatment of infectious diseases presents several challenges, because of insufficient drug efficacy, drug toxicity, and the high cost of current antivirals. Thus, exploring novel strategies and/or the use of safe and effective natural products represents an urgent need to combat viruses . Curcumin has shown antiviral activity against numerous viruses including dengue virus (serotype 2), human immunodeficiency virus, Japanese encephalitis virus, pseudorabies virus, vaccinia virus, parainfluenza virus type 3 (PIV‐3), feline infectious peritonitis virus (FIPV), vesicular stomatitis virus (VSV), herpes simplex virus (HSV), flock house virus (FHV), respiratory syncytial virus (RSV), hepatitis viruses, influenza type A virus (IAV), Ebola virus, and arthropod‐borne viruses .…”

Section: Antiviral Activitymentioning

confidence: 99%

“…Thus, exploring novel strategies and/or the use of safe and effective natural products represents an urgent need to combat viruses . Curcumin has shown antiviral activity against numerous viruses including dengue virus (serotype 2), human immunodeficiency virus, Japanese encephalitis virus, pseudorabies virus, vaccinia virus, parainfluenza virus type 3 (PIV‐3), feline infectious peritonitis virus (FIPV), vesicular stomatitis virus (VSV), herpes simplex virus (HSV), flock house virus (FHV), respiratory syncytial virus (RSV), hepatitis viruses, influenza type A virus (IAV), Ebola virus, and arthropod‐borne viruses . Different possible mechanisms have been reported for curcumin's antiviral properties such as functioning as an HIV‐1 integrase inhibitor , degrading viral Tat protein , inhibiting proteases , inhibiting viral entry , inhibiting virus attachment to cells , and inhibiting viral replication .…”

Section: Antiviral Activitymentioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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Overview on the antiviral activities and mechanisms of marine polysaccharides from seaweeds

Cited by 166 publications

References 93 publications

Addition of Wakame seaweed (Undaria pinnatifida) stalk to animal feed enhances immune response and improves intestinal microflora in pigs

Addition of Wakame seaweed (Undaria pinnatifida) stalk to animal feed enhances immune response and improves intestinal microflora in pigs

Antibacterial and Antiviral Activities of Local Thai Green Macroalgae Crude Extracts in Pacific White Shrimp (Litopenaeus vannamei)

Biological properties of metal complexes of curcumin

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