Overview on toxicity of nanoparticles, it's mechanism, models used in toxicity studies and disposal methods – A review

J, Jane Cypriyana P; Saigeetha, S.; J, Lavanya Agnes Angalene; Samrot, Antony V.; Suresh, S.; Ponniah, Paulraj; Chakravarthi, Srikumar

doi:10.1016/j.bcab.2021.102117

Cited by 52 publications

(22 citation statements)

References 184 publications

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“…The theory of biological synthesis that underpins many organisms is increasingly being developed to tolerate conditions of metal concentration. These microorganisms have the ability to convert more toxic chemicals and substances into less toxic components that are hazardous or even alter them into complex, non-toxic compounds [60]. The development of nanoparticles is the formation of "consequences" of the procedure of an organism into a specific metal at high concentrations.…”

Section: Biological Methodsmentioning

confidence: 99%

“…As a result, the biological process is the most suited and suggested method for AgNP synthesis [59]. There is currently an urgent need to develop sustainable procedures and methods for nanoparticles, as AgNP is needed for use in areas directly related to human activities [60]. We can establish a safe strategy for employing AgNP synthesis by improving our understanding of green synthesis and sustainable technology.…”

Section: Fig 2 Variations Of Nanoparticles Shape ■ Green Synthesis (B...mentioning

confidence: 99%

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A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

Salnus¹,

Wahab

Arfah

et al. 2022

Indones. J. Chem.

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Nanotechnology explores nanoscale materials that can be used in a wide range of industries such as biotechnology, cosmetics, drug delivery, nanomedicine, and biosensors. Nanoparticles in diverse shapes and sizes can be prepared through physical, chemical, and biological methods. The employment of reducing agents, which will change their form, size range, level of stability, and interaction, is a crucial part thus employing a biological approach is necessary. Chemically generated metal oxide nanoparticles raise considerable issues owing to the usage of hazardous and poisonous chemicals, as well as the potential for conservational impairment. In contrast, the production of silver nanoparticles using the principal method of green synthesis has found a special place in research that is considered more environmentally approachable requiring the use to produce non-toxic nanomaterials. Plants and polymer materials have received a lot of interest in the preparation of nanoparticles since they are renewable and affordable. In this review, we present a comprehensive overview of more ecologically friendly synthesis techniques that use plant extracts to make silver nanoparticles and their application as antibacterial agents, as well as toxicity features based on the shape, size range, and phytochemical mechanism of plants.

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Section: Biological Methodsmentioning

confidence: 99%

Section: Fig 2 Variations Of Nanoparticles Shape ■ Green Synthesis (B...mentioning

confidence: 99%

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

Salnus¹,

Wahab

Arfah

et al. 2022

Indones. J. Chem.

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“…Generally, it is assumed that nanoparticles exhibit low cytotoxicity [11]. However, some scientists raise the issue of the mechanism of nanoparticles accumulation in live organisms, which is not well studied yet [174][175][176][177] especially, that nanoparticle toxicity is related to their structure (dimension and architecture) and characteristics (particle surface charge described by zeta potential, value of polydispersity index, surface functionalization) [178]. Most often, the smaller the particles, the greater their biological activity.…”

Section: Modern Wound Dressing Materials and Nanomaterialsmentioning

confidence: 99%

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

et al. 2022

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Wound management is the burning problem of modern medicine, significantly burdening developed countries’ healthcare systems. In recent years, it has become clear that the achievements of nanotechnology have introduced a new quality in wound healing. The application of nanomaterials in wound dressing significantly improves their properties and promotes the healing of injuries. Therefore, this review paper presents the subjectively selected nanomaterials used in wound dressings, including the metallic nanoparticles (NPs), and refers to the aspects of their application as antimicrobial factors. The literature review was supplemented with the results of our team’s research on the elements of multifunctional new-generation dressings containing nanoparticles. The wound healing multiple molecular pathways, mediating cell types, and affecting agents are discussed herein. Moreover, the categorization of wound dressings is presented. Additionally, some materials and membrane constructs applied in wound dressings are described. Finally, bacterial participation in wound healing and the mechanism of the antibacterial function of nanoparticles are considered. Membranes involving NPs as the bacteriostatic factors for improving wound healing of skin and bones, including our experimental findings, are discussed in the paper. In addition, some studies of our team concerning the selected bacterial strains’ interaction with material involving different metallic NPs, such as AuNPs, AgNPs, Fe3O4NPs, and CuNPs, are presented. Furthermore, nanoparticles’ influence on selected eukaryotic cells is mentioned. The ideal, universal wound dressing still has not been obtained; thus, a new generation of products have been developed, represented by the nanocomposite materials with antibacterial, anti-inflammatory properties that can influence the wound-healing process.

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“…They can reach the environment during usage or disposal of AgNPs or consumer products that contain AgNPs. Actually, different methods are under evaluation for nanowaste management with the aim to diminish their potential release into the environment ( Jane Cypriyana et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

Corsi

Desimone

Cazenave

2022

Front. Bioeng. Biotechnol.

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Nanotechnologies have rapidly grown, and they are considered the new industrial revolution. However, the augmented production and wide applications of engineered nanomaterials (ENMs) and nanoparticles (NPs) inevitably lead to environmental exposure with consequences on human and environmental health. Engineered nanomaterial and nanoparticle (ENM/P) effects on humans and the environment are complex and largely depend on the interplay between their peculiar properties such as size, shape, coating, surface charge, and degree of agglomeration or aggregation and those of the receiving media/body. These rebounds on ENM/P safety and newly developed concepts such as the safety by design are gaining importance in the field of sustainable nanotechnologies. This article aims to review the critical characteristics of the ENM/Ps that need to be addressed in the safe by design process to develop ENM/Ps with the ablility to reduce/minimize any potential toxicological risks for living beings associated with their exposure. Specifically, we focused on silver nanoparticles (AgNPs) due to an increasing number of nanoproducts containing AgNPs, as well as an increasing knowledge about these nanomaterials (NMs) and their effects. We review the ecotoxicological effects documented on freshwater and marine species that demonstrate the importance of the relationship between the ENM/P design and their biological outcomes in terms of environmental safety.

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Overview on toxicity of nanoparticles, it's mechanism, models used in toxicity studies and disposal methods – A review

Cited by 52 publications

References 184 publications

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

A Review on Green Synthesis, Antimicrobial Applications and Toxicity of Silver Nanoparticles Mediated by Plant Extract

Composite Membrane Dressings System with Metallic Nanoparticles as an Antibacterial Factor in Wound Healing

Building the Bridge From Aquatic Nanotoxicology to Safety by Design Silver Nanoparticles

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