Overview: pulmonary vascular function in health and disease

Shimoda, Larissa A.

doi:10.1113/jp277375

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…PVR was originally based on Poiseuille's law, which describes the pressure loss caused by fluid flowing through a thin tube, which is proportional to the product of volume flow rate, viscosity coefficient and tube length, and inversely proportional to the 4th power of the tube diameter. It is suitable for Newtonian fluids that are incompressible, do not have acceleration, laminar flow and are longer than the pipe diameter [ 4 – 6 ]. But blood is not fluid, and it is not laminar, and the pulmonary blood vessels are also contractible.…”

Section: Introductionmentioning

confidence: 99%

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Deng¹

2021

J Cardiothorac Surg

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Pulmonary arterial hypertension is a type of malignant pulmonary vascular disease, which is mainly caused by the increase of pulmonary vascular resistance due to the pathological changes of the pulmonary arteriole itself, which eventually leads to right heart failure and death. As one of the diagnostic indicators of hemodynamics, pulmonary vascular resistance plays an irreplaceable role in the pathophysiology, diagnosis and treatment of pulmonary arterial hypertension. It provides more references for the evaluation of pulmonary arterial hypertension patients. This article summarizes the clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension.

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Section: Introductionmentioning

confidence: 99%

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Deng¹

2021

J Cardiothorac Surg

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Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis

Wu,

Chen

et al. 2023

Biol Proced Online

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Background In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), this study aimed to identify the immune activation effect on different sites and the survival outcomes of radioimmunotherapy at different treatment stages. Methods Forty-five patients diagnosed with ES-SCLC were included in this retrospective analysis. We collected the overall survival (OS) of the patients,, recorded the blood cell counts before, during, and after RT, and derived blood index ratios such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). The datasets were analyzed using the Spearman rank correlation test, Kruskal–Wallis rank sum test and logistic regression. Results Among the selected blood indices, the delta-NLR/PLR/Sll correlated with different irradiated organs, and the mean ranks of these three indices were the lowest in the brain-irradiated group during immunotherapy. Additionally, adjunct first-line immunotherapy with RT demonstrated a significant improvement compared to second- or third-line therapy and subsequent therapies. Conclusion Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.

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Immune activation effects at different irradiated sites and optimal timing of radioimmunotherapy in patients with extensive-stage small cell lung cancer: a real-world analysis

Wang

Chen

et al. 2023

Preprint

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Background In view of the limited data on radiotherapy (RT) combined with immunotherapy in patients with extensive-stage small cell lung cancer (ES-SCLC), this study aimed to identify the immune activation effect on different sites and the survival outcomes of radioimmunotherapy at different treatment stages. Methods Forty-five patients diagnosed with ES-SCLC were included in this retrospective analysis. We collected the overall survival (OS) of the patients,, recorded the blood cell counts before, during, and after RT, and derived blood index ratios such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). The datasets were analyzed using the Spearman rank correlation test, Kruskal-Wallis rank sum test, logistic regression, and survival analysis. Results Among the selected blood indices, the delta-NLR/PLR/Sll correlated with different irradiated organs, and the mean ranks of these three indices were the lowest in the brain-irradiated group during immunotherapy. Additionally, adjunct first-line immunotherapy with RT demonstrated a significant improvement compared to second- or third-line therapy and subsequent therapies. Conclusion Our findings suggest that compared to other organs, the strongest immune activation effect occurs with brain RT, and ES-SCLC patients who received radioimmunotherapy (RIT) earlier achieved higher OS rates.

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Overview: pulmonary vascular function in health and disease

Cited by 3 publications

References 17 publications

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Clinical application of pulmonary vascular resistance in patients with pulmonary arterial hypertension

Immune Activation Effects at Different Irradiated Sites and Optimal Timing of Radioimmunotherapy in Patients with Extensive-Stage Small Cell Lung Cancer: a Real-World Analysis

Immune activation effects at different irradiated sites and optimal timing of radioimmunotherapy in patients with extensive-stage small cell lung cancer: a real-world analysis

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