Overview: Regeneration and Repair

Salvi, Richard

doi:10.1007/978-0-387-73364-7_1

Cited by 2 publications

(2 citation statements)

References 248 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, upon cochlear tissue damage, type II SGN afferents likely function very similarly to pain-sensing neurons of the mammalian somatosensory system. Although it is pure speculation, perhaps over evolutionary time it became advantageous for type II SGNs to extend toward the base to make preferential contact with the more basal OHCs, which are most vulnerable to noise damage and aging [90-93]. Possible auditory nociception connectivity patterns in the CNS need further investigation, as it is uncertain what kind of pain noxious noise exposure generates (earache or headache) [87], and to what extent there may be connectivity with somatosensory centers in the CNS.…”

Section: Newly Emerging Concepts In the Function Of Type II Sgnsmentioning

confidence: 99%

Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear

Zhang

Coate

2017

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

In hearing, mechanically sensitive hair cells (HCs) in the cochlea release glutamate onto spiral ganglion neurons (SGNs) to relay auditory information to the central nervous system (CNS). There are two main SGN subtypes, which differ in morphology, number, synaptic targets, innervation patterns and firing properties. About 90-95% of SGNs are the type I SGNs, which make a single bouton connection with inner hair cells (IHCs) and have been well described in the canonical auditory pathway for sound detection. However, less attention has been given to the type II SGNs, which exclusively innervate outer hair cells (OHCs). In this review, we emphasize recent advances in the molecular mechanisms that control how type II SGNs develop and form connections with OHCs, and exciting new insights into the function of type II SGNs.

show abstract

Section: Newly Emerging Concepts In the Function Of Type II Sgnsmentioning

confidence: 99%

Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear

Zhang

Coate

2017

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

show abstract

“…The AP and BP are thought to differ in the mechanism of hair cell tuning. AP tuning is based on a travelling wave in the tectorial membrane sharpened through electrical tuning in the hair cells [31,33,38,39]. AP tuning may be more malleable, in general, owing to the physiological component of its tuning.…”

Section: Discussionmentioning

confidence: 99%

Hearing conspecific vocal signals alters peripheral auditory sensitivity

Gall

Wilczynski

2015

Proc. R. Soc. B.

View full text Add to dashboard Cite

We investigated whether hearing advertisement calls over several nights, as happens in natural frog choruses, modified the responses of the peripheral auditory system in the green treefrog, Hyla cinerea. Using auditory evoked potentials (AEP), we found that exposure to 10 nights of a simulated male chorus lowered auditory thresholds in males and females, while exposure to random tones had no effect in males, but did result in lower thresholds in females. The threshold change was larger at the lower frequencies stimulating the amphibian papilla than at higher frequencies stimulating the basilar papilla. Suprathreshold responses to tonal stimuli were assessed for two peaks in the AEP recordings. For the peak P1 (assessed for 0.8-1.25 kHz), peak amplitude increased following chorus exposure. For peak P2 (assessed for 2-4 kHz), peak amplitude decreased at frequencies between 2.5 and 4.0 kHz, but remained unaltered at 2.0 kHz. Our results show for the first time, to our knowledge, that hearing dynamic social stimuli, like frog choruses, can alter the responses of the auditory periphery in a way that could enhance the detection of and response to conspecific acoustic communication signals.

show abstract

Overview: Regeneration and Repair

Cited by 2 publications

References 248 publications

Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear

Recent advances in the development and function of type II spiral ganglion neurons in the mammalian inner ear

Hearing conspecific vocal signals alters peripheral auditory sensitivity

Contact Info

Product

Resources

About