Overviews of Biomimetic Medical Materials

Das, Dipankar; Noh, Insup

doi:10.1007/978-981-13-0445-3_1

Cited by 17 publications

(11 citation statements)

References 142 publications

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“…Other concerns around the use of biomaterial-based hydrogels include low availability of the required clinical-grade biomaterials, batch–batch variability, difficulty for sterilization and standardization operating procedures, and uncertainty of the optimal time window and delivery route. For a more in-depth review about this subject, we direct the readers to other reviews [ 67 , 124 , 125 , 126 ].…”

Section: Development Of Functional Biomaterials For Cardiac Tissue En...mentioning

confidence: 99%

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Häneke

Sahara

2022

IJMS

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The human heart has the least regenerative capabilities among tissues and organs, and heart disease continues to be a leading cause of mortality in the industrialized world with insufficient therapeutic options and poor prognosis. Therefore, developing new therapeutic strategies for heart regeneration is a major goal in modern cardiac biology and medicine. Recent advances in stem cell biology and biotechnologies such as human pluripotent stem cells (hPSCs) and cardiac tissue engineering hold great promise for opening novel paths to heart regeneration and repair for heart disease, although these areas are still in their infancy. In this review, we summarize and discuss the recent progress in cardiac tissue engineering strategies, highlighting stem cell engineering and cardiomyocyte maturation, development of novel functional biomaterials and biofabrication tools, and their therapeutic applications involving drug discovery, disease modeling, and regenerative medicine for heart disease.

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Section: Development Of Functional Biomaterials For Cardiac Tissue En...mentioning

confidence: 99%

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Häneke

Sahara

2022

IJMS

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“…Based on the previously described methods, the absence of a dermis featuring the 2D models, means that neither the ECM remodeling, nor the dermis-epidermis cross talk have been considered during the in vitro studies of the wound. Bilayer skin models comprising dermis and epidermis have been developed to increase the mimicking potential of the wound healing process in vivo [ 53 , 54 , 55 , 56 , 57 , 58 ]. The tissue engineering approach, aiming at reproducing a functional and structural dermal substitute, relies on the creation of three-dimensional scaffolds as an ECM analogue to guide cell adhesion, growth and differentiation.…”

Section: Full-thickness Models: Toward the Replication Of Deep Wounds...mentioning

confidence: 99%

Bioengineered Wound Healing Skin Models: The Role of Immune Response and Endogenous ECM to Fully Replicate the Dynamic of Scar Tissue Formation In Vitro

et al. 2022

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The healing of deep skin wounds is a complex phenomenon evolving according with a fine spatiotemporal regulation of different biological events (hemostasis, inflammation, proliferation, remodeling). Due to the spontaneous evolution of damaged human dermis toward a fibrotic scar, the treatment of deep wounds still represents a clinical concern. Bioengineered full-thickness skin models may play a crucial role in this direction by providing a deep understanding of the process that leads to the formation of fibrotic scars. This will allow (i) to identify new drugs and targets/biomarkers, (ii) to test new therapeutic approaches, and (iii) to develop more accurate in silico models, with the final aim to guide the closure process toward a scar-free closure and, in a more general sense, (iv) to understand the mechanisms involved in the intrinsic and extrinsic aging of the skin. In this work, the complex dynamic of events underlaying the closure of deep skin wound is presented and the engineered models that aim at replicating such complex phenomenon are reviewed. Despite the complexity of the cellular and extracellular events occurring during the skin wound healing the gold standard assay used to replicate such a process is still represented by planar in vitro models that have been largely used to identify the key factors regulating the involved cellular processes. However, the lack of the main constituents of the extracellular matrix (ECM) makes these over-simplistic 2D models unable to predict the complexity of the closure process. Three-dimensional bioengineered models, which aim at recreating the closure dynamics of the human dermis by using exogenous biomaterials, have been developed to fill such a gap. Although interesting mechanistic effects have been figured out, the effect of the inflammatory response on the ECM remodelling is not replicated yet. We discuss how more faithful wound healing models can be obtained by creating immunocompetent 3D dermis models featuring an endogenous ECM.

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“…Nanomaterials generally range in size from 1 to 100 nm, making them similar in size to basic biological structures (Xiang et al, 2014). Based on their physical, chemical, and biocompatibility properties, nanomaterials are attractive for use in biomedical applications and show great potential in biomimetic medicine (Ning et al, 2017;Das and Noh, 2018;Hasanzadeh et al, 2018). Using biomimetic design principles can overcome the shortcomings of traditional nanoparticles, such as being easily recognized by the immune system and potential toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Using biomimetic design principles can overcome the shortcomings of traditional nanoparticles, such as being easily recognized by the immune system and potential toxicity. Recently, with the development of biomimetic functionalized nanotechnology, nanomaterials have been modified and functionalized by biomolecules or cell membrane-derived components to form biomimetic nanomaterials with enhanced stability, targeting specificity, and biocompatibility (Das and Noh, 2018;Vijayan et al, 2018). Biomimetic nanomaterials, functional materials with biomedical applications, have made it easier to simulate biological functions and reaction processes (Das and Noh, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, with the development of biomimetic functionalized nanotechnology, nanomaterials have been modified and functionalized by biomolecules or cell membrane-derived components to form biomimetic nanomaterials with enhanced stability, targeting specificity, and biocompatibility (Das and Noh, 2018;Vijayan et al, 2018). Biomimetic nanomaterials, functional materials with biomedical applications, have made it easier to simulate biological functions and reaction processes (Das and Noh, 2018). The biomimetic functionalized modification of nanomaterials can create selectivity for disease biomarkers or tissues, suggesting that these biomimetic nanomaterials can be used for disease diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Advanced Biomimetic Nanomaterials for Non-invasive Disease Diagnosis

et al. 2021

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In modern society, the incidence of cancer, inflammatory diseases, nervous system diseases, metabolic diseases, and cardiovascular diseases is on the rise. These diseases not only cause physical and mental suffering for patients, but also place an enormous burden on society. Early, non-invasive diagnosis of these diseases can reduce the physical and mental pain of patients and social stress. There is an urgent need for advanced materials and methods for non-invasive disease marker detection, large-scale disease screening, and early diagnosis. Biomimetic medical materials are synthetic materials designed to be biocompatible or biodegradable, then developed for use in the medical industry. In recent years, with the development of nanotechnology, a variety of biomimetic medical materials with advanced properties have been introduced. Biomimetic nanomaterials have made great progress in biosensing, bioimaging, and other fields. The latest advance of biomimetic nanomaterials in disease diagnosis has attracted tremendous interest. However, the application of biomimetic nanomaterials in disease diagnosis has not been reviewed. This review particularly focuses on the potential of biomimetic nanomaterials in non-invasive disease marker detection and disease diagnosis. The first part focuses on the properties and characteristics of different kinds of advanced biomimetic nanomaterials. In the second part, the recent cutting-edge methods using biosensors and bioimaging based on biomimetic nanomaterials for non-invasive disease diagnosis are reviewed. In addition, the existing problems and future development of biomimetic nanomaterials is briefly described in the third part. The application of biomimetic nanomaterials would provide a novel and promising diagnostic method for non-invasive disease marker detection, large-scale clinical screening, and diagnosis, promoting the exploitation of devices with better detection performance and the development of global clinical public health.

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Overviews of Biomimetic Medical Materials

Cited by 17 publications

References 142 publications

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Progress in Bioengineering Strategies for Heart Regenerative Medicine

Bioengineered Wound Healing Skin Models: The Role of Immune Response and Endogenous ECM to Fully Replicate the Dynamic of Scar Tissue Formation In Vitro

Advanced Biomimetic Nanomaterials for Non-invasive Disease Diagnosis

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