This paper describes a versatile, multi-domain, large power grid real-time digital simulator. Its ability to conduct multiple tests for protection coordination studies is described. A large grid model built using the EMTP-RV software and simulated in real-time using the eMEGAsim platform's EMTP-RT software tool is described. A discussion and comparisons on the different solvers offered with both simulation environments are made. Comparisons between offline and Real-Time simulations are made using superimposed fault condition waveforms. Finally, multiple random tests are performed on the featured power system model and analyzed using the eMEGAsim simulator's software package.