Overweight and childhood psoriasis

Boccardi, Daniela; Menni, S.; Vecchia, Carlo La; Nobile, Maria; Decarli, Adriano; Volpi, Giordana; Ferraroni, Monica

doi:10.1111/j.1365-2133.2009.09276.x

Cited by 66 publications

(67 citation statements)

References 10 publications

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“…Cases with familial clustering tend to have an earlier age of onset (55,56), and one study has observed self-reported age of onset before 16 years in up to one-third of all psoriasis patients, though the finding has not been verified in population-based studies, such as the classic 1948 Faroese study (57). Interestingly, a recent study has confirmed a link between overweight and childhood-onset psoriasis (58). The assumption that being overweight precedes psoriasis is dependent on the presupposition that age of psoriasis onset in our study does not differ systematically from what has been previously reported.…”

Section: Discussionsupporting

confidence: 67%

High Body Mass Index in Adolescent Girls Precedes Psoriasis Hospitalization

Bryld¹,

Sørensen²,

Andersen³

et al. 2010

Acta Derm Venerol

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Psoriasis is associated with being overweight, but the temporal relationship is not known. This historical cohort study tested whether severe psoriasis resulting in hospitalization in adulthood was preceded by excess increase in age-adjusted body mass index, a known risk factor in childhood for being overweight in adulthood. The study cohort was based on the Copenhagen School Health Records Register, birth years 1930 to 1984 (309,152 schoolchildren). Cases were found through the Danish National Patient Register for the period 1977 to 2001. A total of 1074 (0.36%) of the schoolchildren were identified as having psoriasis, with at least one hospital admission. Multivariate analysis demonstrated an association between excess increase in body mass index and psoriasis in females only. Being overweight in adolescence was the main factor behind this observation. The female group showed a significant association between psoriasis and body mass index at ages 12 (p = 0.028) and 13 years (p = 0.010). This was not the case for males or for body mass index measured at ages 11 years and below.

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Section: Discussionsupporting

confidence: 67%

High Body Mass Index in Adolescent Girls Precedes Psoriasis Hospitalization

Bryld¹,

Sørensen²,

Andersen³

et al. 2010

Acta Derm Venerol

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“…Studies of childhood psoriasis indicate an increased risk for metabolic co-morbidities (7)(8)(9)(10)35). In our material 13% of the children were overweight and 1.8% obese in the whole material according to the definition by Cole et al (25).…”

Section: Discussionmentioning

confidence: 55%

“…Studies of the paediatric and adolescent populations also suggest an increased risk for metabolic dysfunction (7)(8)(9)(10), but with no evidence that onset in childhood per se would predispose for overweight and cardio-metabolic comorbidity in adulthood (11,12). However, the difficult issue of causality has not been clarified and studies of body mass index (BMI) and lipoprotein profiles at onset of disease are lacking.…”

mentioning

confidence: 99%

Clinical Characterisation at Onset of Childhood Psoriasis – A Cross Sectional Study in Sweden

Lysell¹,

Tessma²,

Nikamo³

et al. 2015

Acta Derm Venerol

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Epidemiological data in childhood psoriasis are accumulating. However, reliable information captured at onset is lacking. In a cross sectional study we recruited 109 children < 16 years within 12 months of psoriasis onset and explored the clinical characteristics. Pre-pubertal children, especially boys, more often had inverse involvement (OR = 2.8, 95% CI = 1.1, 7.1, p ≤ 0.05). HLA-C*06 was positively associated with facial lesions (OR = 3.8, 95% CI = 1.5, 9.7, p < 0.01) and guttate phenotype and was more common in pubertal children. A high PASI score was not associated with overweight or early age at onset, and gender did not influence disease onset. Psoriasis can be difficult to diagnose in children, especially in pre-pubertals. Thorough examination of facial and genital areas can help in establishing the diagnosis. Our published genetic data in combination with the clinical findings presented herein indicate that puberty may separate different populations of childhood psoriasis.

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“…15 Several studies have shown that patients with pediatric psoriasis in the United States and around the world have a higher prevalence of overweight and obesity compared with unaffected controls. 6,16 It is unclear whether being overweight or obese predisposes to psoriasis or affects the severity of disease in children, but a preliminary study noted overweight or obesity predated psoriasis by at least 2 years in 25 of 27 children. 17 It is hypothesized that having excess adipose tissue and an associated proinflammatory state with increased cytokine (eg, tumor necrosis factor [TNF]) expression, may predispose susceptible individuals to development of psoriasis.…”

Section: Methodsmentioning

confidence: 99%

Pediatric Psoriasis Comorbidity Screening Guidelines

et al. 2017

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IMPORTANCE-Psoriasis is a complex inflammatory skin condition associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins in childhood in almost one-third of patients, early identification of risk may be critical to minimizing effects on future health. OBJECTIVE-To develop the first set of guidelines for comorbidity screening for patients with pediatric psoriasis based on current evidence. EVIDENCE REVIEW-A literature review was performed using PubMed from January 1999 through December 2015. Limiting the search to human studies published in English and removing reviews and editorials produced 153 relevant manuscripts. An expert panel in psoriasis, pediatric dermatology, pediatric rheumatology, pediatric gastroenterology, pediatric endocrinology, and adult and pediatric cardiology used the patient-centered Strength of Recommendation Taxonomy (SORT) method to evaluate and grade the quality of evidence.FINDINGS-Because of the limited number of pediatric studies published on these topics, the strength of the panel's recommendations is classified as SORT level C expert consensus recommendations. The majority of recommendations coincide with those endorsed by the American Academy of Pediatrics for the general pediatric patient but with added attention to signs Osier et al.

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Overweight and childhood psoriasis

Cited by 66 publications

References 10 publications

High Body Mass Index in Adolescent Girls Precedes Psoriasis Hospitalization

High Body Mass Index in Adolescent Girls Precedes Psoriasis Hospitalization

Clinical Characterisation at Onset of Childhood Psoriasis – A Cross Sectional Study in Sweden

Pediatric Psoriasis Comorbidity Screening Guidelines

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