Overweight and obesity accelerate the progression of IgA nephropathy: prognostic utility of a combination of BMI and histopathological parameters

Kataoka, Hiroshi; Ohara, Miho; Shibui, Kaori; Sato, Masayo; Suzuki, Tomo; Amemiya, Nobuyuki; Watanabe, Yoshihiko; Honda, Kazuho; Mochizuki, Takahiro; Nitta, Kosaku

doi:10.1007/s10157-012-0613-7

Cited by 67 publications

(50 citation statements)

References 29 publications

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“…These studies are typically described as validation studies, although none prospectively studied new cohorts; nevertheless they provide valuable corroborative evidence. Sixteen such studies [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] , including cohorts from Europe, North America, and East Asia were meta-analysed in a report published in 2013 21 . Lately, more studies have been published including cohorts from Iran, Europe, Japan and Korea [22][23][24][25][26][27][28] .…”

Section: Published Retrospective Validation Studiesmentioning

confidence: 99%

Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group

Trimarchi

Barratt

Cattran

et al. 2017

Kidney International

893

719

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Section: Published Retrospective Validation Studiesmentioning

confidence: 99%

Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group

Trimarchi

Barratt

Cattran

et al. 2017

Kidney International

893

719

View full text Add to dashboard Cite

show abstract

“…Other risk factors are numerous and controversial but not widely confirmed. They include age at disease onset, sex, overweight or obesity, serum albumin, hemoglobin, hypertriglyceridemia or hyperuricemia, and various immunogenetic markers (8)(9)(10)(11)(12)(13)(14). Using these factors, several risk scoring systems have been developed (6,9,15) for evaluating the rate of IgAN progression.…”

Section: Introductionmentioning

confidence: 99%

Progression of IgA Nephropathy under Current Therapy Regimen in a Chinese Population

Liu

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Current therapy for IgA nephropathy mainly includes renin-angiotensin system inhibitors and adding steroids for patients with persistent proteinuria. This study aimed to evaluate kidney disease progression and its risk factors in a Chinese cohort under current therapy.Design, setting, participants, & measurements Patients with IgA nephropathy followed up for at least 12 months from a prospective database were involved. Renal survival and the relationship between clinical parameters and composite kidney failure events (defined as end stage kidney failure or eGFR halving) were assessed.Results Overall, 703 patients between 2003 and 2011 were enrolled in this study, with a mean follow-up time of 45 months. Mean eGFR was 84.0 ml/min per 1.73 m 2 , systolic BP was 124 mmHg, and time-averaged mean arterial pressure was 90.0 mmHg. Median proteinuria at baseline was 1.60 g/d, and time-averaged proteinuria was 0.80 g/d. The mean rate of eGFR decline was 23.12 ml/min per 1.73 m 2 per year (95% confidence interval, 219.07 to 11.80), and annual end stage kidney failure rate was 2.3%. Multivariate Cox regression analyses revealed that baseline eGFR (hazard ratio, 0.76 per 10 ml/min per 1.73 m 2 ; 95% confidence interval, 0.66 to 0.91), proteinuria at 6 months (hazard ratio, 1.53 per g/d; 95% confidence interval, 1.27 to 1.84), and systolic BP control at 6 months (hazard ratio, 1.36 per 10 mmHg; 95% confidence interval, 1.05 to 1.77) were associated with composite kidney failure events. Baseline eGFR (regression coefficient, 20.06; 95% confidence interval, 20.07 to 20.04), time-averaged proteinuria (regression coefficient, 20.21; 95% confidence interval, 20.25 to 20.16), and time-averaged mean arterial pressure (regression coefficient, 20.15; 95% confidence interval, 20.21 to 20.09) were independent predictors of the slope of eGFR by linear regression.Conclusion Lower proteinuria and lower BP were associated with slower eGFR decline and lower risk of end stage kidney failure in patients currently being treated for IgA nephropathy.

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“…In this case, urinary protein excretion appeared, followed by a 10 kg weight gain. Recently, Kataoka et al (28) showed a BMI " 25 kg/m 2 to be an independent predictor of disease progression in IgA nephropathy, suggesting that even a mild overweight status might contribute to a progression of renal injury in the setting of renal impairment.…”

Section: Discussionmentioning

confidence: 99%

Secondary Focal Segmental Glomerulosclerosis in an Adolescent Born with a Very Low Birth Weight

et al. 2014

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A 17-year-old man presented with a decreased renal function (creatinine clearance 66.0 ml/min/1.73 m 2 ) and proteinuria (1.25 g/24 hrs). He was born weighing 1,065 g 26 weeks of pregnancy. He was mildly overweight (BMI 26.9 kg/m 2 ) due to an increased weight gain (10 kg) over the past year. Renal biopsy showed perihilar sclerosing lesions in three of eleven glomeruli, low glomerular density, enlarged glomeruli, and limited fusions of foot processes, thus indicating secondary focal segmental glomerulosclerosis (FSGS). We speculated that the patient's overweight status may have caused a worsening of glomerular hyperfiltration due to the fewer number of nephrons leading to the development of secondary FSGS.

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Overweight and obesity accelerate the progression of IgA nephropathy: prognostic utility of a combination of BMI and histopathological parameters

Abstract: A combination of BMI ≥25 kg/m(2), the Oxford classification M1, and a Max GA ≥42,900 μm(2) can serve as a predictor of long-term renal outcome of IgAN.

Cited by 67 publications

References 29 publications

Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group

Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group

Progression of IgA Nephropathy under Current Therapy Regimen in a Chinese Population

Secondary Focal Segmental Glomerulosclerosis in an Adolescent Born with a Very Low Birth Weight

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