Overweight and obesity in young adults with patellofemoral pain: Impact on functional capacity and strength

Ferreira, Amanda Schenatto; Mentiplay, Benjamin F.; Taborda, Bianca; Pazzinatto, Marcella Ferraz; Azevedo, Fábio Mícolis de; Silva, Danilo de Oliveira

doi:10.1016/j.jshs.2020.12.002

Cited by 18 publications

(10 citation statements)

References 61 publications

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“…Torque data will be normalised to participant body mass (N m kg −1 ). RTD will be derived from the slope of the torque/time curve, obtained by dividing the normalised torque variation (N m kg −1 , represented as %) by the time variation (ms) from the onset of the contraction 77 78…”

Section: Methodsmentioning

confidence: 99%

Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol

et al. 2023

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IntroductionRunning is one of the most popular recreational activities worldwide, due to its low cost and accessibility. However, little is known about the impact of running on knee joint health in runners with and without a history of knee surgery. The primary aim of this longitudinal cohort study is to compare knee joint structural features on MRI and knee symptoms at baseline and 4-year follow-up in runners with and without a history of knee surgery. Secondary aims are to explore the relationships between training load exposures (volume and/or intensity) and changes in knee joint structure and symptoms over 4 years; explore the relationship between baseline running biomechanics, and changes in knee joint structure and symptoms over 4 years. In addition, we will explore whether additional variables confound, modify or mediate these associations, including sex, baseline lower-limb functional performance, knee muscle strength, psychological and sociodemographic factors.Methods and analysisA convenience sample of at least 200 runners (sex/gender balanced) with (n=100) and without (n=100) a history of knee surgery will be recruited. Primary outcomes will be knee joint health (MRI) and knee symptoms (baseline; 4 years). Exposure variables for secondary outcomes include training load exposure, obtained daily throughout the study from wearable devices and three-dimensional running biomechanics (baseline). Additional variables include lower limb functional performance, knee extensor and flexor muscle strength, biomarkers, psychological and sociodemographic factors (baseline). Knowledge and beliefs about osteoarthritis will be obtained through predefined questions and semi-structured interviews with a subset of participants. Multivariable logistic and linear regression models, adjusting for potential confounding factors, will explore changes in knee joint structural features and symptoms, and the influence of potential modifiers and mediators.Ethics and disseminationApproved by the La Trobe University Ethics Committee (HEC-19524). Findings will be disseminated to stakeholders, peer-review journals and conferences.

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Section: Methodsmentioning

confidence: 99%

Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol

et al. 2023

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“…Сильний і тривалий больовий синдром часто супроводжується економічними витратами, падінням продуктивності праці та підвищенням ризику виникнення інших захворювань. За даними літератури, загальна вартість витрат, пов'язаних із проблемою болю сягає близько 3% від валового внутрішнього продукту європейських країн, що набагато перевищує вартість лікування раку чи захворювань серця [4,5].…”

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Experimental study of analgesic mechanisms of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid derivative (compound NI-9) in rat

Malchenko¹,

Волощук²,

Hrymalovska³

2021

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The problem of effective and safe treatment of pain syndromes is a priority area of modern medicine, since pain syndrome is often accompanied by economic costs, a drop in labor productivity and an increase in the risk of other diseases. The derivative 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide (compound NI-9) has shown a significant analgesic effect in various models of pain syndromes. The aim of this work was to experimentally study the mechanisms of the analgesic activity of compound NI-9 using pharmacological analyzers in the tail-flick test. The study was performed on 210 male Wistar rats. Statistical processing of the obtained results was performed using the software package STATISTICA 10.0 with the calculation of the mean value, standard error of the mean, confidence interval (p). The experiments used: naloxone, prazosin, clonidine, yohimbine, isoproterenol, propranolol, nalbuphine, chlorpromazine, dopamine, nakom, memantine, phenylephrine. The results showed that the opioidergic system was not involved in the antinociceptive effect of compound NI-9. At the same time, the participation of alpha-1 and alpha-2 adrenergic receptors, dopamine receptors, and also partially NMDA receptors has been proven. The data obtained serve as the basis for further preclinical studies of N- (4-methoxybenzyl) -4-methyl-2,2-dixo-1H-2Λ6,1-benzothiazine-3-carboxylic acid (compounds NI-9) as a non-narcotic analgesic, which can compete with already known drugs of this class in the treatment of diseases accompanied by inflammatory and pain syndrome.

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“…However, measurements of BMI do not consider important aspects of body composition (i.e., the distribution of body fat and skeletal muscle mass) that seem to be linked to many musculoskeletal disorders, 29 , 30 , 31 , 32 including PFP. 33 Therefore, the assessment of body composition may provide additional information about the condition. In a recent study, we found that higher body fat and lower skeletal muscle mass, but not BMI, were associated with both poor functional capacity and impaired knee and hip strength in people with PFP.…”

Section: Introductionmentioning

confidence: 99%

Exploring overweight and obesity beyond body mass index: A body composition analysis in people with and without patellofemoral pain

Ferreira

Mentiplay

Taborda

et al. 2023

Journal of Sport and Health Science

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Overweight and obesity in young adults with patellofemoral pain: Impact on functional capacity and strength

Cited by 18 publications

References 61 publications

Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol

Trajectory of knee health in runners with and without heightened osteoarthritis risk: the TRAIL prospective cohort study protocol

Experimental study of analgesic mechanisms of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid derivative (compound NI-9) in rat

Exploring overweight and obesity beyond body mass index: A body composition analysis in people with and without patellofemoral pain

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