Overweight and seminal quality: a study of 794 patients

Martini, Ana Carolina; Tissera, Andrea; Estofán, Daniel; Molina, Rosa; Mangeaud, Arnaldo; Cúneo, Marta Fiol de; Ruiz, Rubén Daniel

doi:10.1016/j.fertnstert.2009.11.017

Cited by 180 publications

(119 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, sperm were not found to be impaired in healthy overweight male partners of subfertile couples [13], whereas Martini et al [30] found a negative association between BMI and sperm motility; as this relation was concomitant with decreased levels of alpha-glucosidase, the authors of the latter study postulated that the impairment of sperm in men with increased BMI was due to a dysfunctional epididymis. The relationship between BMI and MMP has also been reported by La Vignera et al [25].…”

Section: Discussionmentioning

confidence: 93%

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Zorn

Golob

Ihan

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To investigate the relationship between sperm apoptotic biomarkers and patient clinical characteristics, conventional sperm parameters and fertility potential. Material and methods Sperm analysis, phospholipid asymmetry, mitochondrial membrane potential (MMP) and DNA denaturation were assessed in 142 males of infertile couples. Seventy-three couples were allocated to the natural conception group, and 55 couples underwent IVF or ICSI. Results DNA denaturation correlated positively with age and negatively with testicular volume (TV). MMP correlated negatively with BMI and FSH and positively with TV. Normal viable sperm correlated positively with TV and negatively with age, BMI and FSH. DNA denaturation was associated with a significantly lower natural pregnancy rate (OR 5.4, p00.011). Conclusion Sperm apoptosis is related to male age, BMI, testicular volume and FSH. Among the apoptotic markers, only DNA denaturation has been found to predict natural pregnancy better than conventional sperm parameters.

show abstract

Section: Discussionmentioning

confidence: 93%

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Zorn

Golob

Ihan

et al. 2012

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…1,2 Several different disorders can cause male infertility, including idiopathic oligospermia (low sperm counts, for which a specific treatment remains unknown), [3][4][5][6] complete asthenozoospermia (absence of sperm motility; implicated in 19% of infertile cases), 7 and isolated asthenozoospermia (low sperm motility, caused by sperm dysfunction, varicocele, infection, or genetic factors; implicated in 24% of infertile cases). [8][9][10] In the 1970s, several purported causes of male factor infertility received considerable attention. As a consequence, the World Health Organization published both new standardized diagnostic approaches toward male factor infertility 11 and standardized techniques of semen analysis.…”

Section: Introductionmentioning

confidence: 99%

Nutritional modifications in male infertility: a systematic review covering 2 decades

et al. 2015

View full text Add to dashboard Cite

Context: Studies suggest that appropriate nutritional modifications can improve the natural conception rate of infertile couples. Objectives: The purpose of this study was to review the human trials that investigated the relation between nutrition and male infertility. Data Sources: A comprehensive systematic review of published human studies was carried out by searching scientific databases. Article selection was carried out in accordance with Preferred Reporting Items for Systematic Reviews and MetaAnalyses. The American Dietetic Association Research Design and Implementation Checklist was also used for quality assessment. Data Extraction: A total of 502 articles were identified, of which 23 studies met the inclusion criteria. Data Synthesis: Results indicated that a healthy diet improves at least one measure of semen quality, while diets high in lipophilic foods, soy isoflavones, and sweets lower semen quality. Conclusion: The role of daily nutrient exposure and dietary quality needs to be highlighted in male infertility. Mechanistic studies addressing the responsible underlying mechanisms of action of dietary modifications are highly warranted.

show abstract

“…Testosterone and SHBG levels decrease while E2 and TT/E2 increase in obese men [8,17]. Decreased TT and increased E2 in men have been associated with reduction in sperm count and subfertility [18].…”

Section: Discussionmentioning

confidence: 99%

“…Obesity reduces serum levels of sex hormone binding globulin (SHBG) and testosterone (T), and increases serum estradiol (E2) levels in men, but the effects of those changes on fertility is not known clearly [8]. In addition, obesity was found to be associated with erectile dysfunction [9].…”

Section: Introductionmentioning

confidence: 99%

The impact of obesity on semen parameters and hormone levels in infertile men

Özdemir¹,

Tokmak²,

Tuzluoğlu³

et al. 2016

Med-Science

View full text Add to dashboard Cite

Previous studies in overweight men have shown an increased likelihood of abnormal semen parameters. Obesity has been found to be associated with male subfertility. In this study we aimed to investigate the effect of obesity on semen parameters and hormone levels in infertile males. This was a prospective crosssectional study designed to assess the influence of obesity on semen parameters and hormone levels in infertile men. 88 obese [Body mass index (BMI) ≥30 kg/m2] men and 169 non-obese (BMI<30 kg/m2) men were eligible for the study. All semen samples were obtained by masturbation after 3 days of sexual abstinence. After liquefaction at room temperature, semen volume, sperm concentration, motility, and normal morphology were determined according to World Health Organization (WHO, 2010) guidelines for semen analysis. Serum hormone levels were measured on the same-day with semen analysis. Semen volume was significantly lower in the obese group than in the non-obese group. No significant differences were observed between the groups in term of other semen parameters. Mean serum total testosterone (TT) level and TT/estradiol (E2) ratio were significantly higher in the non-obese group, whereas mean E2 level was significantly higher in the obese group. There was a significant positive correlation between BMI and E2 levels in the obese group. A significant inverse correlation was observed between BMI and TT levels in the non-obese group. Obesity may reduce semen volume in infertile males. This effect may be due to the changes in sex hormone levels. However, it has no impact on more meaningful indicators of male fertility such as sperm concentration, motility, and morphology.

show abstract

Overweight and seminal quality: a study of 794 patients

Cited by 180 publications

References 34 publications

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential

Nutritional modifications in male infertility: a systematic review covering 2 decades

The impact of obesity on semen parameters and hormone levels in infertile men

Contact Info

Product

Resources

About