Overweight does not increase asthma risk but may decrease allergy risk at school age after infantile bronchiolitis

Sidoroff, Virpi; Hyvärinen, Mari; Piippo-Savolainen, Eija; Korppi, Matti

doi:10.1111/j.1651-2227.2011.02439.x

Cited by 11 publications

(10 citation statements)

References 31 publications

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“…Results from cohort studies on the association between AD and BMI in older children are conflicting, with some studies reporting a positive association [19, 20], some studies reporting no association [25] and one study reporting a negative association [26]. A meta-analysis of studies in children, adolescents and adults concluded that overweight/obesity is associated with an increased prevalence of AD in North American and Asian countries, but not in European countries [2].…”

Section: Discussionmentioning

confidence: 99%

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

et al. 2017

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BackgroundOverweight and atopic dermatitis (AD) are major health problems in most industrialised countries, but the relationship between overweight and AD in infants and young children is unclear. We investigated if weight-for-length at birth, in infancy and at two years, as well as early weight-gain velocity, are associated with the development of AD in early life.MethodsCohort study of infants (n = 642), all living in south-east Norway, hospitalized with acute bronchiolitis (n = 404) or recruited from the general population (n = 238), examined at mean age 5.1 months (enrolment) and at a two-year follow-up visit (n = 499; 78%) at mean age 24.6 months. Exposures were weight-for-length (g/cm) at birth, enrolment and two-year follow-up, and early weight-gain velocity (gram/month from birth to enrolment). Excessive weight-for-length was defined as weight-for-length >95th percentile of WHO child-growth standards. Data on weight-for-length at the three time points were obtained for 435, 428 and 473 children. AD was diagnosed according to the Hanifin & Rajka criteria or from a history of physician-diagnosed AD. We performed multivariate analyses with weight-for-length at birth, at enrolment and at the two-year follow-up visit and with early weight gain velocity for the endpoint AD at each visit.ResultsIn adjusted analyses, excessive weight-for-length at enrolment was associated with concurrent AD (OR 3.03; 95% CI 1.23–7.50) and with AD at two years (OR 2.40; 1.11–5.17). In infants without AD, weight-for-length at enrolment increased the risk of AD at two years, with OR being 1.02 (95% CI 1.00–1.04) per increased gram/cm. AD at two years was not associated with concurrent excessive weight-for-length, nor was AD at any time associated with weight-for-length at birth or with early weight-gain velocity.ConclusionsThe results suggest that overweight in infancy may contribute to the development of AD in early life, highlighting the need for child health-care professionals to address potential overweight and atopic disease when advising infants’ caregivers.Trial registrationClinicalTrials.gov number, NCT00817466, EudraCT number, 2009–012667-34.

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Section: Discussionmentioning

confidence: 99%

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

et al. 2017

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“…It is important to note that among the forty-five articles reviewed in this study there are also two articles that concluded that no correlation between asthma and Body Mass Index could be found [22,23]. Another articled also mentioned that no relation between weight change in either direction and the incidence or persistence of asthma could be found [24].…”

Section: Obesity Indicators Relation With Asthmamentioning

confidence: 98%

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Rocha¹,

Machado²

2017

J Preg Child Health

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“…After review of the titles and abstracts, 536 articles did not meet our inclusion criteria, and 12 were excluded 31-42 for a lack of data for the frequency of AD/eczema or BMI classification. In total, 30 studies 26,33, were included in the review, of which 20 had valid data that could be pooled to assess for the effects of overweight, 26,43,47,50,[53][54][55][56][57][59][60][61][62][63][64][65][66][67][68][69] 23 for obesity, 26,33,43,45,47,50,[52][53][54][55][56][57][59][60][61][62][63][64][65][66][67][68][69] and 26 for overweight/obesity. 26,43,44,[46]…”

Section: Literature Searchmentioning

confidence: 99%

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

Zhang

Silverberg

2015

Journal of the American Academy of Dermatology

247

213

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Overweight does not increase asthma risk but may decrease allergy risk at school age after infantile bronchiolitis

Abstract: Previous or current overweight does not increase asthma or allergy risk but current obesity may decrease allergy risk at school age after bronchiolitis in infancy.

Cited by 11 publications

References 31 publications

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

Weight-for-length, early weight-gain velocity and atopic dermatitis in infancy and at two years of age: a cohort study

Asthma and Obesity during Childhood: A Review of More than an Occasional Association

Association of atopic dermatitis with being overweight and obese: A systematic review and metaanalysis

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