Overweight-Obesity And Glucose Intolerance In Offspring Of Indian Diabetic Mothers

Ss, Wagle; Phatak, Sanat; Dattatrey, B; Kumaran, Kalyanaraman; Mk, Deshmukh; Kamat, Rajashree; Wadake, S; S, Rangnekar; Ladkat, Rasika; Pc, Yajnik; Yajnik, C.S.

doi:10.1101/2021.05.17.21257222

Cited by 6 publications

(5 citation statements)

References 32 publications

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“…Research conducted by Sonali S. Wagle et al . (2021)[ 16 ] in Pune, India, found more glucose intolerant than ONDMs. On OGTT, the older ODMs (≥10 years) had a higher prevalence of glucose intolerance compared to ONDM.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Profile of Offspring of Mothers with Gestational Diabetes Mellitus

Malik,

Ahmad,

Ashraf

2024

Indian Journal of Endocrinology and Metabolism

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Introduction: Gestational diabetes mellitus (GDM) is defined as diabetes diagnosed in the second or third trimester of pregnancy that was not clearly overt diabetes before gestation. Unrecognized and untreated GDM confers significantly greater maternal and fetal risk, which is largely related to the degree of hyperglycemia. The specific risks of diabetes in pregnancy include but are not limited to, spontaneous abortion, pre-eclampsia, fetal anomalies, macrosomia, neonatal hypoglycemia, hyperbilirubinemia, and respiratory distress syndrome. Additionally, GDM is also implicated in long-term metabolic derangements in the offspring in the form of obesity/overweight, hypertension, dysglycemia, insulin resistance, and dyslipidemias later in life. To determine the prevalence of anthropometric and metabolic derangements in children between 1 and 5 years of age, born to women with GDM. Methods: This hospital-based cross-sectional study was conducted between November 2019 and November 2021 at our Pediatric Endocrine Clinic. Women were diagnosed as having GDM based on the American Diabetes Association Criteria (2019). History regarding the treatment of the GDM (diet only/diet and medical treatment) and detailed physical examination, including anthropometry and blood pressure, were recorded. Blood samples were collected from children for the estimation of their metabolic profile. Results: Overweight, obesity, and severe obesity were present in 18 (11.3%), 2 (1.3%), and 2 (1.3%) children, respectively. Hypertension was found in 21 (19.4%) children. Elevated LDL, triglyceride, and total cholesterol were seen in 3 (1.9%), 84 (52.5%), and 1 (0.6%) children, respectively. Impaired fasting glucose (IFG) was found in 6 (3.8%) children, while 27 (16.9%) subjects were found to be having impaired glucose tolerance after OGTT. Insulin resistance was found in 30 (18.8%) children. GDM mothers with a higher BMI tended to have children with a higher BMI (correlation coefficient, r = .414, P < .001). Higher serum triglyceride levels (r = −0.034, P = 0.672) were recorded in children, irrespective of the BMI of their mothers. There was no significant correlation of maternal BMI with blood pressure (r = −0.134, P = 0.091) or with HOMA-IR (r = 0.00, P = 0.996) in children. However, mothers with a higher BMI had children with statistically higher fasting blood glucose (r = +0.339, P = <0.001) as well as blood glucose 2 hours after OGTT (r = +0.297, P = <0.001). This positive correlation of maternal BMI with the glucose metabolism of their offspring was observed for both male and female genders. Conclusion: Children of women with GDM had a higher BMI, and the mode of treatment for GDM did not lead to differences in childhood BMI. The higher BMI of a GDM mother is associated with altered glucose metabolism in their offspring. Deranged levels of triglyceride across the gender were not found to be statistically significant. This has implications for future metabolic and cardiovascular risks in targeting this group for intervention studies to prevent obesity and disorders of glucose metabolism as one potential strategy to prevent adverse metabolic health outcomes.

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Section: Discussionmentioning

confidence: 99%

Metabolic Profile of Offspring of Mothers with Gestational Diabetes Mellitus

Malik,

Ahmad,

Ashraf

2024

Indian Journal of Endocrinology and Metabolism

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“…Cohort description: The 'Intergenerational programming of diabesity in offspring of women with gestational diabetes mellitus' (InDiaGDM) study investigated the impact of maternal hyperglycemia on the risk of diabesity (diabetes + adiposity) in the offspring and the modifying in uence of vitamin B12 and folate status 25 Biospecimen collection and determination of blood metabolites:The following measurements were made on maternal and cord blood: hemogram (complete blood count), plasma glucose, insulin, total and HDL cholesterol, triglycerides, total vitamin B12, total homocysteine and folate. Supplementary table 1 describes laboratory methods used for these measurements.…”

Section: Methodsmentioning

confidence: 99%

“…Without adjusting for confounding variables and 2. with adjusting for confounding variables (maternal GDM status, adiposity, and maternal vitamin B12 and folate status for maternal samples, and additionally neonatal gender for cord blood samples) bymultiple linear regression analysis. We used a discovery signi cance of p≤0.1 and a FC≥|1.2| and represented it as a volcano plot generated using ggplot2 25 package in R.…”

Section: Methodsmentioning

confidence: 99%

Neonatal Adiposity Is Associated with microRNAs in Adipocyte-Derived Extracellular Vesicles in Maternal and Cord Blood

et al. 2022

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“…The ‘Intergenerational programming of diabesity in offspring of women with gestational diabetes mellitus’ (InDiaGDM) study investigated the impact of maternal hyperglycemia on the risk of diabesity (diabetes + adiposity) in the offspring and the modifying influence of vitamin B12 and folate status 25 . Details of inclusion and exclusion criteria are shown in the flowchart (Supplementary figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…Without adjusting for confounding variables and 2. with adjusting for confounding variables (maternal GDM status, adiposity, and maternal vitamin B12 and folate status for maternal samples, and additionally neonatal gender for cord blood samples) by multiple linear regression analysis. We used a discovery significance of p≤0.1 and a FC≥|1.2| and represented it as a volcano plot generated using ggplot2 25 package in R.…”

Section: Methodsmentioning

confidence: 99%

MicroRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood are related to neonatal adiposity

Kunte¹,

Barberio

Tiwari³

et al. 2022

Preprint

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Background: Maternal body size, nutrition, and hyperglycemia contribute to neonatal body size and composition. There is little information on maternal-fetal transmission of messages which influence fetal growth. We analyzed adipocyte-derived small extracellular vesicular (ADsEV) microRNAs in maternal and cord blood to explore their adipogenic potential. Methods: We studied 127 mother-neonate pairs (51 lean and 76 adipose neonates, in 68 NGT and 59 GDM pregnancies). Adiposity refers to highest tertile (T3) of sum of skinfolds in neonates of normal glucose tolerant (NGT) mothers, lean to lowest tertile (T1). ADsEV miRNAs from maternal and cord blood samples were profiled on Agilent 8*60K microarray. Differential expression (DE) of ADsEV miRNAs in adipose vs. lean neonates was studied before and after adjustment for maternal gestational diabetes mellitus (GDM), adiposity, and vitamin B12-folate status. Results: Multiple miRNAs were common in maternal and cord blood and positively correlated. We identified 24 maternal and 5 cord blood miRNAs differentially expressed (p≤0.1) in the adipose neonate group, and 19 and 26 respectively, in the adjusted analyses. Even though DE miRNAs were different in maternal and cord blood, they targeted similar adipogenic pathways (e.g., the forkhead box O (FOXO) family of transcription factors, mitogen‑activated protein kinase (MAPK) pathway, transforming growth factor beta (TGF-β) pathway). Maternal GDM and adiposity were associated with many DE ADsEV miRNAs. Conclusion: Our results suggest that the DE ADsEV miRNAs in mothers of adipose neonates are potential regulators of fetal adiposity. Further, the composition and functionality of miRNAs may be influenced by maternal hyperglycemia, adiposity, and micronutrient status during pregnancy .

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Overweight-Obesity And Glucose Intolerance In Offspring Of Indian Diabetic Mothers

Cited by 6 publications

References 32 publications

Metabolic Profile of Offspring of Mothers with Gestational Diabetes Mellitus

Metabolic Profile of Offspring of Mothers with Gestational Diabetes Mellitus

Neonatal Adiposity Is Associated with microRNAs in Adipocyte-Derived Extracellular Vesicles in Maternal and Cord Blood

MicroRNAs in adipocyte-derived extracellular vesicles in maternal and cord blood are related to neonatal adiposity

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