“… 20 , 21 In this context, M. sexta is used as a model in ecotoxicology and agricultural science to study and develop new insecticides. 12 , 16 , 19 , 22 , 23 , 24 , 25 Lately, lepidopteran insects were also used as high-throughput preclinical models for diseases involving gut inflammation, including inflammatory bowel disease, which reflects the general homology of the innate immune system and the common epithelial organization of the alimentary tract in insects and mammals. 26 , 27 , 28 , 29 , 30 The high-throughput screening of large compound libraries can help to identify new inhibitors against evolutionarily conserved targets.…”