Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period

Kim, Hye In; Lee, Inha; Kim, Sang Hwa; Lee, Yong Seung; Han, Sang Won; Yun, Bo Hyon

doi:10.1016/j.jpag.2021.02.105

Cited by 8 publications

(2 citation statements)

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“…In the Indonesian series of Juniarto et al, 63.3% of the patients had 46, XY karyotype [13]. Individuals with 46, XY karyotype have the highest risk of developing a malignant gonadal tumor, due to the presence of a non-functional testicular component in the ovotestis, which requires removal of the non-functional gonads [14][15][16][17]. Emphasis is placed on a multidisciplinary approach in order to maximize the potential of these individuals to become normal socially functioning adults [17].…”

Section: Discussionmentioning

confidence: 97%

Ovotesticular disorder 46, XY: A rare case report with review of the literature

BBS

DJIWA³

et al. 2023

Preprint

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Introduction Ovotestis is a rare cause of sexual ambiguity characterized by the presence in a patient of both testicular and ovarian tissue, leading to the development of both male and female structures. We report a case of ovotestis diagnosed in an adolescent, with a review of the literature. Case Report A 15-year-old patient presented with a right scrotal swelling associated with gynecomastia. Histology showed a juxtaposition of ovarian stroma and seminiferous tubules. Karyotype revealed a male subject (XY). Conclusion Ovotestis is a rare finding, heterogeneous in its genetic etiology and clinical presentation. While many patients are diagnosed during infancy or childhood, we presented a case diagnosed in a 15-year-old adolescent.

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Section: Discussionmentioning

confidence: 97%

Ovotesticular disorder 46, XY: A rare case report with review of the literature

BBS

DJIWA³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In the Indonesian series of Juniarto et al, 63.3% of the patients had 46, XY karyotype [ 16 ]. Individuals with 46, XY karyotype have the highest risk of developing a malignant gonadal tumor, due to the presence of a non-functional testicular component in the ovotestis, which requires removal of the non-functional gonads [ 17 – 20 ]. Emphasis is placed on a multidisciplinary approach in order to maximize the potential of these individuals to become normal socially functioning adults [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Ovotesticular disorder of sex development in a 46 XY adolescent: a rare case report with review of the literature

Bbs,

Ad,

Djiwa

et al. 2023

BMC Women's Health

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Introduction : Ovotestis is a rare cause of sexual ambiguity characterized by the presence in a patient of both testicular and ovarian tissue, leading to the development of both male and female structures. We report a case of ovotestis diagnosed in an adolescent, with a review of the literature. Case Report A 15-year-old patient presented with a right scrotal swelling associated with gynecomastia. Histology showed a juxtaposition of ovarian stroma with ovarian follicle and seminiferous tubules. Karyotype revealed a male subject (XY). We have therefore retained the diagnosis of ovotesticular disorders of sex development. Conclusion Ovotestis is a rare finding, heterogeneous in its genetic etiology and clinical presentation. While many patients are diagnosed during infancy or childhood, we presented a case diagnosed in a 15-year-old adolescent.

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