Ovulation Induction

Hofe, Johanna Von; Bates, G. Wright

doi:10.1016/j.ogc.2014.09.007

Cited by 16 publications

(4 citation statements)

References 34 publications

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“…Clomiphene citrate induces ovulation by blocking estrogen receptors, is effective, well-tolerated, safe, and cost-effective and has been recommended as a first-line treatment for women with PCOS who plan for future pregnancy [26–28]. Clomiphene citrate use is recommended at a dose of 100 mg/day or less, but can be increased to up to 250 mg/day if required [29]. In the present study, a 5-day dose of 50 mg/day of clomiphene citrate was used.…”

Section: Discussionmentioning

confidence: 99%

A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate

Yıldırım

Derici

2019

Med Sci Monit

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Background Polycystic ovary syndrome (PCOS) is associated with infertility or subfertility due to impaired ovulation. Clomiphene citrate is a first-line treatment option for the induction of ovulation in women with PCOS. The study aimed to compare markers of oxidative stress or the total oxidative status (TOS), total antioxidant status (TAS), and levels of paraoxonase-1 (PON-1) before and after day 21 of the menstrual cycle in women with PCOS treated with clomiphene citrate to induce ovulation. Material/Methods The study included 75 women who were divided into a control group (n=25) that included healthy untreated women, untreated women with PCOS (n=24) who had spontaneous ovulation, and women with PCOS who were treated with clomiphene citrate for subfertility or infertility (n=26) (the PCOS-CC group). The study group was treated for five days with clomiphene citrate (50 mg/day). Peripheral venous blood was sampled on day 3 and day 21 of the menstrual cycle from women in all three groups, and TAS, TOS, and PON-1 levels were measured. Results In all three groups, TAS and PON levels were significantly reduced and TOS values were significantly increased on day 21 of the menstrual cycle. Comparison of TAS, TOS, and PON-1 levels between the three study groups on day 3 and day 21 of the menstrual cycle showed no significant difference (p=0.600, p=0.223, p=0.956, respectively). Conclusions This study showed that spontaneous ovulation occurs in association with an oxidative state in healthy women and women with PCOS, and women with PCOS following treatment with clomiphene citrate.

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Section: Discussionmentioning

confidence: 99%

A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate

Yıldırım

Derici

2019

Med Sci Monit

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“…Clomiphene citrate (CC is a selective estrogen receptor modulator (SERM). 4 It is used for the induction of ovulation in infertile women with PCOS. However, 20 to 25% of PCOS patients failed to ovulate with incremental doses of CC.…”

Section: Clomiphene Citratementioning

confidence: 99%

Study of the response of PCOS patients to clomiphene citrate based on hormonal Parameters and body mass index

Dhurve,

Narvekar,

Dhanvij

2024

Int J Reprod Contracept Obstet Gynecol

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Background: Our study aimed to evaluate the response of polycystic ovarian syndrome patients to clomiphene citrate based on hormonal parameters and body mass index. Methods: It is a prospective observational study that was carried out on 48 women with PCOS-related infertility. They were treated with an incremental dose of clomiphene citrate starting with 50 mg/day to a maximum of 100 mg. The response was recorded as either the presence or absence of ovulation. Hormonal parameters such as serum FSH, LH, testosterone, fasting insulin, DHEA, prolactin, and body mass index (BMI) were evaluated. The correlation of each of these parameters in predicting non-responsiveness (failure to ovulate with 100 mg clomiphene) was calculated. Results: Among 48 PCOS patients who were enrolled in the study, 14 patients responded to CC 50 mg, 26 patients responded to CC 100 mg and 8 patients were CC non-responders. We concluded that serum LH, fasting insulin, and BMI were significant predictors of response to ovulation with CC in PCOS patients. Conclusions: In our study, we concluded that among the hormonal and biochemical parameters we studied serum LH, fasting insulin, and BMI are significant predictors of response of ovulation with CC in women with PCOS-related infertility. This may help physicians to counsel and select the proper infertility treatment for women with PCOS experiencing infertility so that it should be less time-consuming and cost-effective.

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“…This, however, is very difficult, and current therapy involves daily FSH- and LH-containing injections. The development of follicles is tracked via ultrasound, and ovulation is induced by the administration of human chorionic gonadotropin (hCG) when the follicle is over 18 mm in diameter [ 243 ].…”

Section: Infertility and Assisted Reproductionmentioning

confidence: 99%

History of the Development of Knowledge about the Neuroendocrine Control of Ovulation—Recent Knowledge on the Molecular Background

Szabó,

Köves,

Gál

2024

IJMS

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The physiology of reproduction has been of interest to researchers for centuries. The purpose of this work is to review the development of our knowledge on the neuroendocrine background of the regulation of ovulation. We first describe the development of the pituitary gland, the structure of the median eminence (ME), the connection between the hypothalamus and the pituitary gland, the ovarian and pituitary hormones involved in ovulation, and the pituitary cell composition. We recall the pioneer physiological and morphological investigations that drove development forward. The description of the supraoptic–paraventricular magnocellular and tuberoinfundibular parvocellular systems and recognizing the role of the hypophysiotropic area were major milestones in understanding the anatomical and physiological basis of reproduction. The discovery of releasing and inhibiting hormones, the significance of pulse and surge generators, the pulsatile secretion of the gonadotropin-releasing hormone (GnRH), and the subsequent pulsatility of luteinizing (LH) and follicle-stimulating hormones (FSH) in the human reproductive physiology were truly transformative. The roles of three critical neuropeptides, kisspeptin (KP), neurokinin B (NKB), and dynorphin (Dy), were also identified. This review also touches on the endocrine background of human infertility and assisted fertilization.

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Ovulation Induction

Cited by 16 publications

References 34 publications

A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate

A Case-Control Study on the Oxidative Status in Women with Polycystic Ovary Syndrome Treated with Clomiphene Citrate

Study of the response of PCOS patients to clomiphene citrate based on hormonal Parameters and body mass index

History of the Development of Knowledge about the Neuroendocrine Control of Ovulation—Recent Knowledge on the Molecular Background

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