Ovulation suppression for endometriosis for women with subfertility

Hughes, Edward G.; Brown, Julie; Collins, John J.; Farquhar, Cindy; Fedorkow, Donna M.; Vanderkerchove, Patrick

doi:10.1002/14651858.cd000155.pub2

Cited by 94 publications

(45 citation statements)

References 51 publications

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“…42 Thus, these agents are not recommended for the treatment of infertility and should not delay the pursuit of effective fertility therapies. 18,25 …”

Section: Strategies and Evidencementioning

confidence: 99%

Endometriosis

2010

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“…42 Thus, these agents are not recommended for the treatment of infertility and should not delay the pursuit of effective fertility therapies. 18,25 …”

Section: Strategies and Evidencementioning

confidence: 99%

Endometriosis

2010

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“…Furthermore, the information available about the activity of endometriotic lesions in minimal to mild endometriosis is very scarce [9]. However, GnRH therapy alone without laparoscopy might be ineffective to alleviate endometriosis-associated infertility [26]. …”

Section: Discussionmentioning

confidence: 99%

Pregnancy Rate in Endometriosis Patients according to the Severity of the Disease after Using a Combined Approach of Laparoscopy, GnRH Agonist Treatment and in vitro Fertilization

Sõritsa

Saare²,

Laisk³

et al. 2014

Gynecol Obstet Invest

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Aim: To evaluate the effects of combined treatment approaches on endometriosis-associated infertility in different stages of endometriosis using laparoscopy, gonadotropin-releasing hormone (GnRH) agonist (GnRHa) therapy and in vitro fertilization (IVF). Methods: This retrospective study was carried out on 179 women with surgically confirmed endometriosis. Patients were divided into subgroups: group 1 (stage I-II, n = 121) and group 2 (stage III-IV, n = 58). Patients eligible for IVF, who were found to have adenomyosis or moderate to severe endometriosis, were also given postoperative GnRHa. Pregnancy and delivery rates were cumulatively calculated during 5 years according to the severity of the disease. Results: The overall pregnancy, delivery and miscarriage rates were 66.5, 56.4 and 15.1%, respectively, for all patients following spontaneous and assisted conception. There were no significant differences in reproductive outcomes between the study groups. The pregnancy and delivery rates were also comparable within group 1 between the patients with and without GnRHa treatment. Conclusion: Pregnancy and delivery rates at different stages of endometriosis were not affected by the different approaches used for infertility treatment, with >60 and >50% of patients having conceived and delivered a baby, respectively, in both groups. The usefulness of GnRHa treatment for endometriosis patients with minimal to mild forms is questionable and deserves further studies.

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“…6 The benefit, as measured by subsequent pregnancy, of ovarian suppression with danazol, medroxyprogesterone or gestrinone vs placebo/no treatment has been assessed in a Cochrane review of 13 randomised controlled trials (RCTs). 7 The common odds ratio for pregnancy vs placebo was 0.83 (95 per cent CI 0.5-1.39). The benefit of treatment with gestrinone, GnRH agonists or the COC vs danazol has similarly been assessed: the common odds ratio vs danazol was 1.20 (95 per cent CI 0.85-1.68).…”

Section: Medical Managementmentioning

confidence: 97%