Oxalate in the Human Thyroid Gland

Wahl, Richard L.; Fuchs, Regine; Kallee, E

doi:10.1515/cclm.1993.31.9.559

Cited by 5 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our series, no correlation was found between colloid calcification number and age or gender, conversely to other studies [9,13,14,24]. In accordance with literature, no significant association between colloid calcifications and pathology was shown.…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Localization and characterization of thyroid microcalcifications: A histopathological study

et al. 2019

View full text Add to dashboard Cite

Thyroid calcification is frequent in thyroid nodules. The aim of our study was to evaluate the prevalence of calcifications in thyroid tissue samples of patients with various thyroid diseases, and to identify their composition according to their localization. Among 50 thyroid samples included, 56% were malignant (papillary carcinoma) and 44% were benign (adenoma, multinodular goiter, Graves’ disease, sarcoidosis). Calcifications were found in 95% of samples using polarised light microscopy, whereas only 12% were described in initial pathological reports. Three types were individualised and analyzed by infrared spectrometry (μFTIR): colloid calcifications composed of calcium oxalate, capsular calcifications and psammoma bodies, both composed of calcium phosphate. Of notice, psammoma bodies characterized by FE-SEM were composed of concentric structure suggesting a slow process for crystal deposition. Calcium phosphates were found only in malignant samples whereas calcium oxalate was not associated with a define pathology. Proliferation assessed by KI67 staining was high (33% of positive follicles), and RUNX2, OPN, and CD44 positive staining were detected in thyrocytes with a broad variation between samples. However, thyrocyte proliferation and differentiation markers were not associated with the number of crystals. TRPV5 and CaSR expression was also detected in thyrocytes. mRNA transcripts expression was confirmed in a subgroup of 10 patients, altogether with other calcium transporters such as PMCA1 or Cav1.3. Interestingly, TRPV5 mRNA expression was significantly associated with number of colloid calcifications (rho = -0.72; p = 0.02). The high prevalence of calcium oxalate crystals within colloid gel raises intriguing issues upon follicle physiology for calcium and oxalate transport.

show abstract

Section: Discussionsupporting

confidence: 89%

“…Colloid calcifications are frequent and were found in 79% of autopsies [6]. They are described only in humans and not in animals [6,14] and were reported to contain calcium oxalate [5,6,9,24]. Using μFTIR spectrometry, we could further analyze their composition and found pure COM in 58% of cases and COD or COM + COD in all other cases.…”

Section: Discussionmentioning

confidence: 99%

Localization and characterization of thyroid microcalcifications: A histopathological study

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Patients with primary hyperoxaluria are especially prone to oxalosis, a condition where CaOx deposits have been found in various extrarenal tissues, primarily in the heart, smooth muscle cells of vessels, bones, skin, and other organs [ 45 ]. However, oxalate deposition has also been reported in non-primary hyperoxaluria patients affecting extrarenal tissues such as the breast [ 46 ], lungs [ 47 ], thyroid gland [ 48 ], prostate [ 49 ], synovial fluid [ 50 ], and vascular tissues [ 51 ]. Furthermore, studies have suggested that oxalate may promote the proliferation of cancer and metastatic cells, contributing to the development of breast and prostate cancer [ 36 , 52 , 53 ].…”

Section: Oxalate Implications In Health and Diseasementioning

confidence: 99%

Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives

Stepanova

2023

Biomedicines

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a significant global public health concern associated with high morbidity and mortality rates. The maintenance of oxalate homeostasis plays a critical role in preserving kidney health, particularly in the context of CKD. Although the relationship between oxalate and kidney stone formation has been extensively investigated, our understanding of oxalate homeostasis in non-stone-forming CKD remains limited. This review aims to present an updated analysis of the existing literature, focusing on the intricate mechanisms involved in oxalate homeostasis in patients with CKD. Furthermore, it explores the key factors that influence oxalate accumulation and discusses the potential role of oxalate in CKD progression and prognosis. The review also emphasizes the significance of the gut–kidney axis in CKD oxalate homeostasis and provides an overview of current therapeutic strategies, as well as potential future approaches. By consolidating important findings and perspectives, this review offers a comprehensive understanding of the present knowledge in this field and identifies promising avenues for further research.

show abstract

“…Other diseases may be associated with calcifications, such as nodular goiter or Graves’ disease, and regardless of various studies on the topic, no clear association between calcifications and histopathologic classification has been demonstrated [ 17 , 18 ]. In contrast, microcalcifications in cervical lymph nodes are predictive of PTC metastasis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Aspects of Thyroid Calcification

Ferreira

Gimba

Vinagre

et al. 2020

IJMS

View full text Add to dashboard Cite

In thyroid cancer, calcification is mainly present in classical papillary thyroid carcinoma (PTC) and in medullary thyroid carcinoma (MTC), despite being described in benign lesions and in other subtypes of thyroid carcinomas. Thyroid calcifications are classified according to their diameter and location. At ultrasonography, microcalcifications appear as hyperechoic spots ≤ 1 mm in diameter and can be named as stromal calcification, bone formation, or psammoma bodies (PBs), whereas calcifications > 1 mm are macrocalcifications. The mechanism of their formation is still poorly understood. Microcalcifications are generally accepted as a reliable indicator of malignancy as they mostly represent PBs. In order to progress in terms of the understanding of the mechanisms behind calcification occurring in thyroid tumors in general, and in PTC in particular, we decided to use histopathology as the basis of the possible cellular and molecular mechanisms of calcification formation in thyroid cancer. We explored the involvement of molecules such as runt-related transcription factor-2 (Runx-2), osteonectin/secreted protein acidic and rich in cysteine (SPARC), alkaline phosphatase (ALP), bone sialoprotein (BSP), and osteopontin (OPN) in the formation of calcification. The present review offers a novel insight into the mechanisms underlying the development of calcification in thyroid cancer.

show abstract

Oxalate in the Human Thyroid Gland

Cited by 5 publications

References 24 publications

Localization and characterization of thyroid microcalcifications: A histopathological study

Localization and characterization of thyroid microcalcifications: A histopathological study

Oxalate Homeostasis in Non-Stone-Forming Chronic Kidney Disease: A Review of Key Findings and Perspectives

Molecular Aspects of Thyroid Calcification

Contact Info

Product

Resources

About