Oxalate Kinetics and Reversal of the Complications after Orthotopic Liver Transplantation in a Patient with Primary Hyperoxalosis Type 1 Awaiting Renal Transplantation

Bastani, Bahar; Mistry, BhargavM.; Nahass, GeorgeT.; Joh, Jung; Dundoo, Gayathri; Solomon, Harvey

doi:10.1159/000013428

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…Our subjects were highly selected for normality and may represent unusually healthy liver. Comparison with age‐matched hyperoxalosis normal liver tissue, often used in domino liver transplantation,32‐38 vindicated this approach, as there was no discernible difference in telomere length between the groups.…”

Section: Discussionmentioning

confidence: 99%

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

et al. 2012

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Telomeres, a validated biomarker of aging, comprise multiple nucleotide repeats capping chromosomes that shorten with each cell cycle until a critical length is achieved, precipitating cell senescence. Only two previous studies focused on the effect of aging in ''normal'' liver tissue, but these studies were compromised by small sample size, limited age range, tissue derived from individuals with an increased risk of senescence, and the use of liver homogenates. We developed a robust large-volume, four-color quantitative fluorescent in situ hybridization technique to measure telomere length in large numbers of hepatocytes, Kupffer cells, hepatic stellate cells, CD4-positive and CD8-positive lymphocytes, and cholangiocytes. Following validation against the gold standard (Southern blotting), the technique was applied to normal archived paraffin-embedded liver tissue obtained following reperfusion of implanted donor liver. We studied 73 highly selected donors aged 5-79 years with a short medical illness preceding death and no history of liver disease, reperfusion injury, or steatosis and normal graft function 1-year posttransplantation. Cholangiocytes had significantly longer telomeres compared with all other intrahepatic lineages over a wide age range (P < 0.05). Age-related telomere attrition was restricted to sinusoidal cells (i.e., Kupffer cells [P 5 0.0054] and stellate cells [P 5 0.0001]). Cholangiocytes and hepatocytes showed no age-related telomere shortening. Conclusion: In normal liver and over a broad age range, cholangiocytes have longer telomeres than all other intrahepatic lineages. Age-related telomere length decline is restricted to Kupffer cells and stellate cells. (HEPATOLOGY 2012;56:1510-1520

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Section: Discussionmentioning

confidence: 99%

Sustained telomere length in hepatocytes and cholangiocytes with increasing age in normal liver

et al. 2012

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“…Calcinosis cutis due to the deposition of oxalate in patients with primary hyperoxaluria improves after correction of the metabolic defect by liver transplantation 34. The same holds true for the livedo reticularis occasionally observed in patients with primary hyperoxaluria 35. The photosensitivity affecting patients with erythropoietic protoporphyria as a consequence of ferrochelatase deficiency disappears after liver transplantation but this may take months and even years 36–39.…”

Section: Evolution Of Preexisiting Dermatologic Conditions After Livementioning

confidence: 97%

Nontumoral dermatologic problems after liver transplantation

2004

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The skin, easily accessible for medical examination, is affected in many ways by liver transplantation. Mucocutaneous manifestations of advanced liver disease and dermatologic conditions associated with specific hepatic diagnoses generally improve after liver transplantation. W ith the advent of new immunosuppressive medications and innovative surgical approaches, liver transplantation has become an attractive therapeutic option for liver failure secondary to numerous etiologies. More than 50,000 patients have benefited from liver transplantation worldwide, with an actuarial survival at 5 years above 70%. The resolution of dermatologic conditions such as pruritus participates in the dramatic improvement of the quality of life following liver transplantation. As the survival of these transplanted patients improves, secondary complications such as mucocutaneous pathologies arise. They range from benign conditions to life-threatening diseases. This review addresses the evolution after transplantation of dermatologic conditions related to the underlying liver disease as well as the recognition and treatment of skin diseases appearing specifically after liver transplantation. Skin cancers after liver transplantation will not be considered, as this topic has been previously well documented. [1][2][3][4] In contrast, to our knowledge, there are only two reported series regarding nontumoral dermatologic complications after liver transplantation, 5,6 and most of the published information in this area is in the form of case reports.

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“…113 Treatment with both pyridoxine and orthophosphate improved renal survival from 20% to 74% at 20 years in patients with PHO type I and II. 113 Liver transplantation to treat the enzyme deficiency is the definitive therapy for this condition, 114 but combined kidney-liver transplant may be necessary if nephrocalcinosis has developed. 115…”

Section: Hyperoxaluriamentioning

confidence: 99%