Oxazolidinones as chiral auxiliaries in asymmetric aldol reaction applied to natural products total synthesis

Protonated Porphyrins: Bifunctional Catalysts for the Metal‐Free Synthesis of N‐Alkyl‐Oxazolidinones

“…One of the synthetic routes using carbon dioxide as a renewable reagent is its cycloaddition to three-membered rings such as epoxides [7][8][9][10][11][12] and aziridines. In particular, the reaction of the latter molecules with CO 2 is a 100 % atom-economic procedure forming oxazolidinones, [13] which are largely employed as chiral auxiliaries [14] in organic synthesis as well as building blocks for producing pharmaceuticals. [15][16][17][18] The synthesis of oxazolidinones is efficiently promoted by both homogeneous [19][20][21] and heterogeneous [22][23][24][25] catalytic systems, which are not always in line with dictates of green chemistry.…”

Samarium(ii) iodide-mediated reactions applied to natural product total synthesis

“…In continuation of our interest in total synthesis of natural products, 14 in this reviews we try to underscore the applications of SmI 2 in the total synthesis of natural products covering the literature from 2004 to date.…”

Amine-catalyzed site- and stereo-selective coupling of epoxy amines and carbon dioxide to construct oxazolidinones

“…1). [1][2][3] The synthesis of oxazolidinones has attracted widespread attention, which has been achieved via the cyclization reaction of α-amino acids or 1,2-amino alcohols with carbonyl derivatives, 4 the cycloaddition reaction of isocyanates and epoxides, 5 and intramolecular cyclization of N-Boc-protected propargyl amines. 6 Construction of oxazolidinones starting from CO 2 is attracting increasing interest, as this strategy transforms the renewable and non-toxic C1 synthon into value-added compounds.…”

“…1). 1–3 The synthesis of oxazolidinones has attracted widespread attention, which has been achieved via the cyclization reaction of α-amino acids or 1,2-amino alcohols with carbonyl derivatives, 4 the cycloaddition reaction of isocyanates and epoxides, 5 and intramolecular cyclization of N -Boc-protected propargyl amines. 6…”