Oxcarbazepine: Efficacy, safety, and tolerability in the treatment of mania

Abstract

A twelve-week study examined the efficacy, safety, and tolerability of oxcarbazepine in the treatment of mania. Twenty male subjects, all of whom were stable on valproic acid, qualified for the study. The conversion from valproic acid to oxcarbazepine was completed over a three-week period. Scores from the BPRS, CGI and SAJEE-GI were collected and analyzed. The results of the study supported the efficacy, safety, and tolerability of oxcarbazepine for the treatment of mania. Another potential advantage of oxcarbazepine is a metabolic pathway that may reduce drug interactions. Qnt] Psych Can Pract 2004; 8: 37-40).

Direct Assembly of 3,4‐Difunctionalized Benzofurans and Polycyclic Benzofurans by Phenol Dearomatization and Palladium‐Catalyzed Domino Reaction

“…(3)]. [18] In conclusion, we have developed a method to convert 2-alkynylphenols into 3,4-difunctionalized benzofurans and polycyclic benzofurans. [18] In conclusion, we have developed a method to convert 2-alkynylphenols into 3,4-difunctionalized benzofurans and polycyclic benzofurans.…”

“…Compound 51 has a dibenz [b,f]azepine core, which exists in many natural products and medicinal compounds, such as carbazepine and trileptal. [18] In conclusion, we have developed a method to convert 2-alkynylphenols into 3,4-difunctionalized benzofurans and polycyclic benzofurans. This protocol involves a hypervalentiodine-mediated oxidative dearomatization and a palladiumcatalyzed domino reaction.…”