Oxcarbazepine in the treatment of childhood epilepsy

Oxcarbazepine Treatment of Juvenile-Onset Bipolar Disorder

“…In summary, these two cases suggest that OXC may have mood stabilizing properties in adolescents diagnosed with BD, at doses well below the standard dosage for adults and children (Serdaroglu et al, 2003) with epilepsy.…”

The Safety and Tolerability of Newer Antiepileptic Drugs in Children and Adolescents

“…[59,[157][158][159][160][161][162][163][164][165][166] Less frequent are diplopia (2-26%), ataxia (2-14%), abnormal vision (10-15%), tremor (10-12%), abnormal gait (10%), nystagmus (10%), abnormal or difficult thinking (2-5%) and memory problems (3%). [59,162,163,[165][166][167][168] Most study discontinuations are secondary to somnolence and seizures. Fatigue is reported in 0.4-39%.…”

“…[174,175] In contrast, one study reported decreased generalized epileptiform discharges with oxcarbazepine. [168] Infrequently reported psychiatric adverse effects include aggressive behaviour (3-10%) and anxiety/agitation (2-8%). [59,166,168,176] …”

“…[59,158,[163][164][165][166] Abdominal pain is less common (11%), and increases in alkaline phosphatase and hepatic transaminases may also occur. [157,163,168] Hepatitis is also a rarely reported serious adverse event in children. [166,177] …”

“…[59,162,165,166,168] One study considered worsening of pre-existing eczema a serious oxcarbazepine-related event in a child. [166] Reports of serious rashes are rare in the literature; however, paediatric cases of SJS and TEN have been reported, according to the drug manufacturer.…”