Oxcarbazepine-induced Toxic Epidermal Necrolysis: A Rare Case Report

Abstract

Anti-epileptic medications are highly susceptible to be the causative agents for Steven Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN). Although carbamazepine (CBZ), lamotrigine are the most associated anti-epileptic drug, oxcarbazepine (OXC), which is a monohydrated derivative of CBZ, is suggested to be much safer because of the different metabolic processes of the two drugs. SJS/TEN is an acute life‑threatening severe mucocutaneous reaction, characterized by extensive necrosis and detachment of the epidermis from the skin. The overall incidence of oxcarbazepine induced SJS & TEN is five to six cases per million people per year. Herein, we report a case of TEN induced by oxcarbazepine who recovered following early diagnosis and treatment.