Oxcarbazepine (Trileptal®) monotherapy dramatically improves quality of life in two patients with postherpetic neuralgia refractory to carbamazepine and gabapentin

Criscuolo, Salvatore; Auletta, Caterina; Lippi, S.; Brogi, F.; Brogi, Alessandra

doi:10.1016/j.jpainsymman.2004.10.003

Cited by 8 publications

(1 citation statement)

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“…Oxcarbazapine possess intrinsic pain-relief properties [ 44 ], either considering acute or chronic pain [ 44 , 45 ] and neuropathic pain [ 46 ]. The efficacy of previous studies, its safety, the good tolerance and the limited side effects leads to this study, which confirmed the previously reported data [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C-related cryoglobulinemic neuropathy: potential role of oxcarbazepine for pain control

et al. 2018

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BackgroundPeripheral neuropathy is one most common, limiting and invalidating neurological symptom in subjects with hepatitis C virus and mixed cryoglobulinemia. Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. Therefore, neuropathy therapies are insufficient and inadequate, and comprise immunosuppressive drugs, such as steroid or cyclosporine, intravenous immunoglobulin or plasma exchange. These have shown variable success in case reports, with a presumably temporary effect, but with major side effects.MethodsWe assessed the effects of oxcarbazepine treatment in 67 cases of cryoglobulinemia related neuropathy, who did not respond to either steroid or Gabapentin, or Pregabalin. Oxcarbazepine was chosen based on the promising preliminary results.ResultsPatients treated with Oxcarbazepine showed a rapid, discrete and persistent relief of polyneuropathic signs, without consistent side effects, and with a limited interaction with concomitant drugs.ConclusionsThese data favor the use of oxcarbazepine as a useful tool in the management of neuropathic pain associated with Hepatitis–C cryoglobulin neuropathy.

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