Oxidant and antioxidant balance in children with bacteremia

Aykaç, Kübra; Özsürekçi, Yasemin; Başaranoğlu, Sevgen Tanır; Demir, Osman Oguz; Avcıoğlu, Gamze; Erel, Özcan; Ceyhan, Mehmet

doi:10.23736/s0026-4946.20.05748-5

Cited by 4 publications

(9 citation statements)

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“… 14 , 15 , 16 Oxidative stress has also been found to contribute to the pathogenesis of various pulmonary diseases in children such as pneumonia, asthma, acute bronchiolitis, cystic fibrosis, acute respiratory syndrome, and chronic neonatal pulmonary disease. 17 , 18 Studies have reported a potential link between oxidative stress and the pathogenesis, disease severity, and mortality risk of patients infected with SARS‐CoV‐2. 13 , 19 Karsen et al 20 determined a decrease in TAS and increase in TOS in Brucellosis patients.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown that oxidative stress regulates the host immune system in viral diseases such as hepatitis B, hepatitis C, herpes simplex virus, and influenza 14–16 . Oxidative stress has also been found to contribute to the pathogenesis of various pulmonary diseases in children such as pneumonia, asthma, acute bronchiolitis, cystic fibrosis, acute respiratory syndrome, and chronic neonatal pulmonary disease 17,18 . Studies have reported a potential link between oxidative stress and the pathogenesis, disease severity, and mortality risk of patients infected with SARS‐CoV‐2 13,19 .…”

Section: Discussionmentioning

confidence: 99%

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Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

Gümüş

Erat

Ozturk

et al. 2022

Journal of Medical Virology

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The aim of this study was to investigate the change in nuclear factor erythroid 2-related factor (Nrf2), which plays a critical role in cytoprotection against oxidative stress, in pediatric patients with coronavirus disease 2019 (COVID-19) infection positivity, and to evaluate the relationship between Nrf2 and oxidative balance. The study included 40 children with confirmed COVID-19 infection and 35 healthy children. The groups were compared in respect of Nrf2, total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI), in addition to clinical findings of fever, cough, shortness of breath, contact history, and demographic data of age and gender. The mean Nrf2 values and TAS levels were determined to be statistically significantly low (p < 0.001) and the TOS level and OSI were statistically significantly high in the children with COVID-19 compared to the control group. A significant positive correlation was determined between Nrf2 and TAS (p < 0.01); as the Nrf2 value increased, so the TAS value increased. A significant negative correlation was determined between Nrf2 and TOS and OSI (p < 0.01); as the Nrf2 value increased, there was determined to be a significant decrease in the TOS and OSI values. COVID-19 infection in pediatric patients causes a decrease in the Nrf2 level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

Gümüş

Erat

Ozturk

et al. 2022

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Studies have demonstrated that oxidative stress regulates the host immune system in viral diseases, such as hepatitis B, hepatitis C, herpes simplex virus, and influenza 5–8 . Additionally, oxidative stress can contribute to the pathogenesis of several lung diseases in children, such as pneumonia, asthma, acute bronchiolitis, cystic fibrosis, acute respiratory distress syndrome, and chronic neonatal lung disease 9–11 . Reviews have reported a potential link between oxidative stress and the pathogenesis, severity, and mortality risk of patients infected with severe acute respiratory syndrome coronavirus (SAS‐CoV) 4,12,13 .…”

Section: Introductionmentioning

confidence: 99%

“…[5][6][7][8] Additionally, oxidative stress can contribute to the pathogenesis of several lung diseases in children, such as pneumonia, asthma, acute bronchiolitis, cystic fibrosis, acute respiratory distress syndrome, and chronic neonatal lung disease. [9][10][11] Reviews have reported a potential link between oxidative stress and the pathogenesis, severity, and mortality risk of patients infected with severe acute respiratory syndrome coronavirus (SAS-CoV). 4,12,13 However, to the best of our knowledge, no clinical study has been performed in children with COVID-19 to investigate the oxidant and antioxidant stress parameters.…”

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confidence: 99%

Oxidant and antioxidant balance in patients with COVID‐19

Aykaç

Özsürekçi

Yayla

et al. 2021

Pediatric Pulmonology

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Background: A crucial balance exists between oxidant and antioxidant mechanisms in the functional immune system. We aimed to evaluate the contributions of balance between these systems to coronavirus disease 2019 (COVID-19), a devastating pandemic caused by viral infection.Method: We analyzed serum oxidant and antioxidant stress parameters according to the clinical and demographic characteristics of children and adults with COVID-19 and compared them against the values of healthy controls. Serum native thiol (NT), total thiol (TT), disulfide, total antioxidant status, total oxidant status, and ischemia-modified albumin levels were evaluated and compared between groups.Results: A total of 79 children and 74 adults were evaluated in the present study, including 46 children and 40 adults with COVID-19, 33 healthy children, and 34 healthy adults. TT, NT, and disulfide levels were significantly lower in the adult COVID-19 group than in all other groups (p = .001, p = .001, and p = .005, respectively). Additionally, TT and NT levels were significantly lower in both pediatric and adult COVID-19 cases with severe disease course than mild/moderate course. TT and NT levels were identified as predictors for the diagnosis of the adult COVID-19 cases and as independent predictors for disease severity in both children and adults with COVID-19. Conclusion:Parameters that reveal the oxidant and antioxidant capacity, including TT and NT, appear to be good candidates for the accurate prediction of the clinical course among patients with COVID-19.

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“…In a study of Aykac et al,22 50 children with bacteremia and 63 healthy children were included. Twenty-two children (44%) with bacteremia had malignant diseases.…”

Section: Discussionmentioning

confidence: 99%

Clinical Utility of Total Oxidative Stress and Total Antioxidant Capacity in Childhood Febrile Neutropenia

Kara

Akyürek²,

Akbas

et al. 2021

Journal of Pediatric Hematology/Oncology

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The aim is to determine the oxidative status of children with febrile neutropenia (FEN). Blood samples were collected to determine the total antioxidant capacity (TAC) and total oxidative status (TOS) of healthy children (once) and children with FEN after 0, 48, and 96 hours. Eighteen patients with FEN were evaluated. The baseline TAC level of patients was significantly higher than that of the controls (P<0.0001). The TAC levels of patients with FEN with and without antibiotic modification were higher than those of the controls (P=0.002 and 0.02, respectively). The TAC levels of the patients with FEN with antibiotic modification were lower than those of the patients without antibiotic modification (P=0.0224). The oxidative stress index (OSI), calculated TOS/TAS, value of the children with FEN was lower than that of the controls (P<0.0001). The OSI values of the patients with FEN with and without antibiotic modification were lower than those of the control group (P=0.001 and <0.0001, respectively). The TAC values of the patients with antibiotic modification were higher than those of the patients without antibiotic modification (P=0.02). In conclusion, the oxidative status of the children with FEN was affected, and it can give information about the follow-up of FEN.

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Oxidant and antioxidant balance in children with bacteremia

Cited by 4 publications

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Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

Oxidative stress and decreased Nrf2 level in pediatric patients with COVID‐19

Oxidant and antioxidant balance in patients with COVID‐19

Clinical Utility of Total Oxidative Stress and Total Antioxidant Capacity in Childhood Febrile Neutropenia

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