Oxidant-Antioxidant Status Alterations in Cancer Patients: Relationship to Tumor Progression

Gerber, Mariette; Astre, C.; Ségala, Claire; Saintot, M.; Scali, Jacqueline; Simony-Lafontaine, Joëlle; Grenier, Jean; Pujol, H

doi:10.1093/jn/126.suppl_4.1201s

Cited by 39 publications

(26 citation statements)

References 17 publications

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“…The deleterious effects of lipoperoxides on survival appear to contradict the results of our previous [3][4][5] and present cross-sectionnal studies. Most studies relating to the possible role of lipoperoxides in breast cancer carcinogenesis have investigated the role of PUFA as a highly peroxidable substrate.…”

Section: Discussioncontrasting

confidence: 99%

“…The deleterious effects of vitamin E appear to contradict the results of previous studies [3][4][5] and also what one would expect in relation to the role of vitamin E, an inhibitor of PUFA peroxidation. The relationship between plasma and tissue vitamin E levels and breast cancer is inconsistent.…”

Section: Discussioncontrasting

confidence: 83%

“…Moreover, it was found that plasma antioxidants and lipid peroxidation were inversely associated with tumor size. 3 These results were completed by cross-sectional studies 4,5 of other cancer sites, which also showed that the risk of tumor growth increased 3-fold in the class of cancer patients in which plasma lipoperoxides were below 0.3 mol/l.…”

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confidence: 95%

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Oxidant‐antioxidant status in relation to survival among breast cancer patients

Saintot

Mathieu-Daude²,

Astre³

et al. 2001

Intl Journal of Cancer

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The role of plasma oxidant-antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients (n ‫؍‬ 363) hospitalized in Southern France between 1989 and 1992. The median follow-up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after diagnosis and before surgery and adjuvant therapy. We found an inverse relationship between plasma lipoperoxides (MDA) and tumor size at diagnosis, together with higher lipoperoxide levels in node-negative tumors than in node-positive ones (TNM). The longitudinal approach revealed an increased risk of recurrence for patients with plasma lipoperoxides in the highest tertile of the sample (RR ‫؍‬ 2.1, 95%CI 1.1-4.0). In addition, the risk of recurrence increased (RR ‫؍‬ 1.7, 95%CI 1.0 -3.0), after adjustment for the known prognostic factors (TNM), for patients with plasma lipid-adjusted vitamin E levels of over 22 mol/l. The risk of breast cancer death was twice as great for patients with plasma lipid-adjusted vitamin E levels above this value. Excesses of plasma lipoperoxides and vitamin E appear to be factors in poor prognosis for breast cancer-specific survival (OVS) and disease-free survival (DFS), respectively, independent of tumor characteristics at diagnosis. Several hypotheses are advanced to explain the possible role of plasma vitamin E as a factor in poor prognosis for survival. © 2002 Wiley-Liss, Inc. Key words: breast cancer; survival; lipoperoxides; vitamin EA previous cross-sectional study that we had conducted 1 showed a statistically significant higher plasma vitamin E level in breast cancer patients than in controls. In line with these data, another of our studies 2 had shown that lipid peroxidation measured by malondialdehyde formation was lower in patients than in controls. Moreover, it was found that plasma antioxidants and lipid peroxidation were inversely associated with tumor size. 3 These results were completed by cross-sectional studies 4,5 of other cancer sites, which also showed that the risk of tumor growth increased 3-fold in the class of cancer patients in which plasma lipoperoxides were below 0.3 mol/l.These findings suggested that the oxidant-antioxidant status of patients could influence tumor growth and proliferative activity and subsequently overall survival and risk of recurrence after surgery. This hypothesis has also been investigated in other studies of both animal 6,7 and human tumors. 8 The present longitudinal study was therefore conducted to investigate the plasma concentrations of lipoperoxides, vitamin E (an antioxidant lipophile) and glutathione peroxidase (an antioxidant enzyme) as relevant prognostic factors for risk of death or recurrence for breast cancer patients. MATERIAL AND METHODS Patients and tumor characteristicsThe present study was carried out at the Val d'Aurelle-Paul

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 83%

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Oxidant‐antioxidant status in relation to survival among breast cancer patients

Saintot

Mathieu-Daude²,

Astre³

et al. 2001

Intl Journal of Cancer

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“…Both electrontransfer physical effects (catalytic formation and then rotational/vibrational dissipation of the triplet excited state of the carotenoid) and chemical reactions (consuming the beta-carotene or oxidizing the beta-carotene) are involved in inactivating peroxy and alkoxy radical species, and superoxide anion. Radical addition to carotenoids from lipid peroxyl radicals can be induced by the effect on lipid membranes of singlet oxygen, nitrogen dioxide, or thiyl radical (derived from the interaction of NO2 with glutathione) (23,29). Carotenoids differ in their propensity to react through these various pathways with various radicals and in different in vitro test systems.…”

Section: Mechanisms Of Actionmentioning

confidence: 99%

CHEMOPREVENTION OF LUNG CANCER: The Rise and Demise of Beta-Carotene

Omenn

1998

Annu. Rev. Public Health

160

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Beta-carotene and retinoids were the most promising agents against common cancers when the National Cancer Institute mounted a substantial program of population-based trials in the early 1980s. Both major lung cancer chemoprevention trials not only showed no benefit, but had significant increases in lung cancer incidence and in cardiovascular and total mortality. A new generation of laboratory research has been stimulated.Rational public health recommendations at this time include: 1. Five-A-Day servings of fruits and vegetables, a doubling of current mean intake; 2. systematic investigation of the covariates of extremes of fruit and vegetable intake; 3. discouragement of beta-carotene supplement use, due to adverse effects in smokers and no evidence of benefit in non-smokers; 4. multilevel research to develop and evaluate candidate chemoprevention agents to prevent lung and other common cancers; and 5. continued priority for smoking prevention, smoking cessation, and avoidance of known carcinogens in the environment.

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“…Oxidative stress in the target tissue has been suggested to play an important role in carcinogenic process. Thus, Se may act as an antitumoural agent although more studies are needed to investigate the actual role of antioxidants and their possible relationships with trace elements alterations in the pathogenesis of breast cancer (Bock et al, 1991;Gerber et al, 1996). Furthermore, it has been shown that Se supplementation decreases the COX-2 protein and PGE-2 levels in colorectal cancer cells.…”

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Selenium in serum and neoplastic tissue in breast cancer: correlation with CEA

et al. 2006

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Trace element selenium (Se) is regarded to be a breast cancer preventive factor involved in multiple protective pathways. In all, 80 women with breast cancer who underwent a radical mastectomy were enrolled in the study. Serum Se and carcinoembryonic antigen levels were measured using a fluorometric and IRMA assay, respectively. Se tissue concentration was determined by a tissue extracting fluorometric assay. For statistical analysis purposes t -test was used and P -values <0.001 were regarded as statistically significant. Serum Se was 42.5±7.5 μ g l −1 in breast cancer patients and 67.6±5.36 μ g l −1 in the age-matched control group of healthy individuals. Serum carcinoembryonic antigen in patients was 10±1.7 U ml −1 (normal <2.5 U ml −1 in nonsmokers/<3.5 U ml −1 in smokers). A statistically significant difference was found for both serum Se and CEA between two groups studied ( P <0.001). Neoplastic tissue Se concentration was 2660±210 mg g −1 tissue; its concentration in the adjacent non-neoplastic tissue was 680±110 mg g −1 tissue ( P <0.001). An inverse relationship between Se and CEA serum levels was found in the two groups studied ( r =−0.794). There was no correlation between serum/tissue Se concentration and stage of the disease. The decrease in serum Se concentration as well as its increased concentration in the neoplastic breast tissue is of great significance. These alterations may reflect part of the defence mechanisms against the carcinogenetic process.

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Oxidant-Antioxidant Status Alterations in Cancer Patients: Relationship to Tumor Progression

Cited by 39 publications

References 17 publications

Oxidant‐antioxidant status in relation to survival among breast cancer patients

Oxidant‐antioxidant status in relation to survival among breast cancer patients

CHEMOPREVENTION OF LUNG CANCER: The Rise and Demise of Beta-Carotene

Selenium in serum and neoplastic tissue in breast cancer: correlation with CEA

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