Oxidant/antioxidant status in men with Behçet’s disease

Taysı, Seyithan; Demircan, Berna; Akdeniz, Necmettın; Atasoy, Mustafa; Sari, Refik Ali

doi:10.1007/s10067-006-0513-x

Cited by 48 publications

(47 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ceruloplasmin (CP) produced by hepatocytes is an acute phase protein and has antioxidant characteristics (Gutteridge et al 1985). It has been reported that the activity of CP increases in patients with BD (Kose et al 1995;Taysi et al 2002).…”

Section: Measurement Of the Total Antioxidant Statusmentioning

confidence: 99%

Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Işık

Koca

Üstündağ

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Behcet's disease (BD) is a chronic systemic inflammatory disease. Inflammatory reactions trigger the oxidative stress and oxidants decrease the level of antioxidants. In the present study, we aimed to determine serum oxidative/antioxidative status in patients with BD. Serum antioxidative status was evaluated by measuring total antioxidant capacity (TAC), paraoxonase 1, arylesterase, sulfhydryl groups and ceruloplasmin in patients with BD and in healthy controls. Serum oxidative status was evaluated by measuring total peroxide (TP), lipid hydroperoxides and oxidative stress index (OSI). OSI was calculated by percent ratio of TP to TAC. Serum levels of TAC, sulfhydryl groups and activities of paraoxonase 1, arylesterase, and ceruloplasmin were significantly lower in patients than in controls ( p < 0.001 for all). In contrast, TP, lipid hydroperoxides and OSI values were significantly higher in patients than in controls ( p < 0.001 for all). Further, the level of TAC was negatively correlated with the levels of TP, lipid hydroperoxides and OSI both in the BD (r = −0.578, p < 0.01; r = −0.559, p < 0.01 and r = −0.552, p < 0.01, respectively) and the control groups (r = −0.469, p < 0.05; r = −0.351, p < 0.05 and r = −0.391, p < 0.05, respectively). These results indicate that the oxidant parameters increased and antioxidant parameters decreased in patients with BD; therefore, these patients might have been exposed to oxidative stress. We suggest that impaired oxidant/ antioxidant balance should be taken into consideration in the follow-up of patients with BD.

show abstract

Section: Measurement Of the Total Antioxidant Statusmentioning

confidence: 99%

Decreased Total Antioxidant Response and Increased Oxidative Stress in Behcet's Disease

Işık

Koca

Üstündağ

et al. 2007

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…18 It has been shown that Mn-SOD genotypes containing the variant A allele were found to be associated with a 1.5-fold increased risk of breast cancer compared with those with the homozygous wild-type genotype (Mn-SOD VV). 17 Taysi et al 7 found that erythrocyte SOD activities were increased in BD compared to healthy controls whereas the other antioxidant enzymes, glutathione S transferase, catalase, and GPx were decreased. In another study, which investigated the oxidant-antioxidant status in whole blood from BD and controls, GPx was found to be decreased similarly to the previous paper.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from several studies suggests that neutrophils from patients with BD generate high levels of ROS and then this stress causes endothelial cell lysis in vitro. [3][4][5] On the other hand, different data reported in the literature show a variation for the activities of antioxidant enzymes in BD: erythrocyte superoxide dismutase (SOD) activity was found to be increased, 4,6,7 unchanged, 8 and decreased, 5,9 glutathione reductase activity was found to be increased, 7 catalase, glutathione reductase and glutathione peroxidase (GPx) activities were found to be decreased, [5][6][7][8][9] and ultimately, erythrocyte catalase activity was found to be unchanged 4 in BD patients.…”

mentioning

confidence: 99%

Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet’s Disease

Yılmaz

Yağcı

et al. 2016

Arch Rheumatol

View full text Add to dashboard Cite

Objectives: This study aims to investigate the genetic association between single nucleotide mutation in mitochondrial manganese superoxide dismutase and a Behçet's disease (BD) population by using molecular techniques. Patients and methods: Ninety-three BD patients (45 males, 48 females; mean age 33.15±8.99 years; range 17 to 65 years) and 125 controls (58 males, 67 females; mean age 28.33±7.31 years; range 18 to 62 years) were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. The genotypic distributions in BD patients and controls were consistent with the Hardy-Weinberg equilibrium. Results: Significant differences were observed between BD patients and controls in terms of genotypic distribution. Frequencies of alanine (Ala)/Ala, Ala/valine (Val), and Val/Val were 14.0% (n=13), 45.2% (n=42), and 40.9% (n=38) in BD patients and 21.6% (n=27), 53.6% (n=67), and 24.8% (n=31) in controls, respectively (p=0.033). Conclusion:The Val/Val genotype of the manganese superoxide dismutase gene is associated with the physiopathology of BD in a group of Turkish patients.Keywords: Behçet's disease; manganese superoxide dismutase; polymerase chain reaction-restriction fragment length polymorphism; polymorphism.Behçet's disease (BD) is a chronic, multi-systemic, relapsing, and inflammatory disorder characterized by ocular manifestations, in particular. 1 It is also characterized by uveitis, recurrent oral ulceration, genital ulceration, and skin lesions. BD exists worldwide, but it is relatively more widespread in Middle Eastern and East Asian countries including Japan. 2 The effect of autoimmune response and genetic factors on etiology of BD was well established. 2 However, the etiologic mechanisms underlying this vascular disease have not been well understood yet. Reactive oxygen species (ROS) have been hypothesized to play an important role in BD. Evidence from several studies suggests that neutrophils from patients with BD generate high levels of ROS and then this stress causes endothelial cell lysis in vitro. [3][4][5] On the other hand, different data reported in the literature show a variation for the activities of antioxidant enzymes in BD: erythrocyte superoxide dismutase (SOD) activity was found to be increased, 4,6,7 unchanged, 8 and decreased, 5,9

show abstract

“…6 Serum MDA levels have been reported to be higher in patients with active and inactive ocular BD, and non-ocular BD compared to the control group. 7 Studies have also found increased MDA levels in patients with active disease than those inactive disease. 8 Furthermore, highly elevated serum MDA in patients with BD is an evidence of increased lipid peroxidation during the active stage of the disease.…”

Section: Introductionmentioning

confidence: 99%

“…The active ocular and nonocular BD groups were found to have significantly elevated ESR levels compared to the inactive ocular BD group. 7 When neutrophils and macrophages are stimulated by pathogens, cytokines and other inflammatory mediators such as C-reactive protein (CRP), are released from granules into the cytoplasm and they play a major role in destroying phagocytosed materials. CRP and ESR levels are sensitive markers of inflammation and reflect the activity of BD.…”

mentioning

confidence: 99%