Oxidase Enzyme Activities and Their Correlations with Antioxidative Stress Biomarkers in Patients with Acute Coronary Syndrome in Bangladesh

Ferdausi, Nourin; Anik, Md. Eahsanul Karim; Binti, Nabila Nawar; Islam, Laila N.

doi:10.4236/wjcd.2020.104017

Cited by 4 publications

(5 citation statements)

References 36 publications

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“…As reported by other workers (Messner and Bernhard, 2014;and Messerli et al, 2017), the present study found smoking and previous history of hypertension to be significantly higher in patients with ACS who were screened to exclude those suffering from diabetes mellitus, and any other chronic inflammatory disorder to avoid false-positive results. In contrast to a recent investigation (Ferdausi et al, 2020), this study found a significant association between breathlessness and family history of CVD in the development of ACS. However, the patients enrolled in this study were already hospitalized and being treated with antihypertensive drugs; thus, the observed blood pressure and pulse rate might not be the same as the time of MI attack.…”

Section: Discussioncontrasting

confidence: 99%

Role of complete blood count, antioxidants, and total antioxidant capacity in the pathophysiology of acute coronary syndrome

Haque¹,

Hafiz²,

Habib³

et al. 2022

African Journal of Biological Sciences

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Acute Coronary Syndrome (ACS) resulting from sudden rupture of arterial plaques with exposure of highly thrombogenic fatty deposits in the coronary arteries is one of the most common causes of mortality worldwide, needs further attention. In this case control study, a total of 138 patients with ACS and 134 non-ACS controls were enrolled. The Red Blood Cell (RBC) count, hemoglobin, and hematocrit were significantly lower in patients. The White Blood Cell (WBC) and platelet counts, and neutrophil to lymphocyte ratio were significantly higher in patients (11.76 ± 2.49 × 10 6 cells/mL, 343.80 ± 113.76 × 10 9 cells/L, and 3.88 ± 2.24, respectively), which strongly indicated inflammatory responses. The serum and RBC lysate reduced glutathione (GSH), antioxidant vitamins -C, D and alpha-tocopherol, total bilirubin, and Total Antioxidant Capacity (TAC) were significantly lower in ACS patients (3.78 ± 1.53 and 384.21 ± 184.86 µmol/L, 0.30 ± 0.22 mg/dL, 49.46 ± 47.11 ng/mL, 2.66 ± 3.67 µg/mL, 0.51 ± 0.27 mg/dL and 533.61 ± 232.47 µmol/L, respectively). Their serum GSH showed significant positive correlation with vitamin C and hemoglobin, and significant negative correlations were found between WBC count and serum GSH, and platelet count with TAC. Neutrophils and platelets play pivotal roles in mediating inflammatory responses, and significant reduction of antioxidants cause increased oxidative stress in patients with ACS, indicating that administration of antioxidant vitamins could reduce oxidative stress and inflammatory conditions.

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Section: Discussioncontrasting

confidence: 99%

Role of complete blood count, antioxidants, and total antioxidant capacity in the pathophysiology of acute coronary syndrome

Haque¹,

Hafiz²,

Habib³

et al. 2022

African Journal of Biological Sciences

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“…Жүрөк-кан тамыр оорулары медициналык технологиядагы жана дарылоодогу жетишкендиктерге карабастан, дүйнө жүзү боюнча ооруканага жаткыруу жана өлүмдүн негизги себеби болуп калууда (Manckoundia et al, 2017). Атап айтканда, жүрөк-кан тамыр ооруларынын таралышы өнүккөн жана өнүгүп келе жаткан өлкөлөрдө да өсүп, аларды олуттуу глобалдык ден-соолукка тынчсыздандырууда (Ferdausi et al, 2020). Көптөгөн тобокелдик факторлор жүрөккан тамыр ооруларына, анын ичинде гипертония, диабет, семирүү жана тамеки тартууга өбөлгө түзөт.…”

Section: аннотацияunclassified

“…

Cardiovascular diseases continue to be the leading cause of hospitalization and mortality worldwide, despite advancements in medical technology and treatments (Manckoundia et al, 2017). In particular, the prevalence of cardiovascular diseases is increasing in both developed and developing countries, making them a significant global health concern (Ferdausi et al, 2020). Numerous risk factors contribute to cardiovascular diseases, including hypertension, diabetes, obesity, and smoking.

…”

mentioning

confidence: 99%

Heart Attack: A Comparative Study of Kyrgyzstan and Indian Treatment Methods

Abdieva,

Seitova,

Chauhan

et al. 2023

ВОГУМ

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Cardiovascular diseases continue to be the leading cause of hospitalization and mortality worldwide, despite advancements in medical technology and treatments(Manckoundia et al., 2017). In particular, the prevalence of cardiovascular diseases is increasing in both developed and developing countries, making them a significant global health concern(Ferdausi et al., 2020). Numerous risk factors contribute to cardiovascular diseases, including hypertension, diabetes, obesity, and smoking.

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“…The NADPH oxidase (NOX) activity was measured according to the method established by Reusch and Burger [15], as detailed previously [16]. Briefly, a cocktail (450 μL) was prepared with phosphate buffer, nano-pure water and EDTA (4:4:1).…”

Section: Measurements Performedmentioning

confidence: 99%

Oxidative Stress and Inflammatory Leukocyte Markers in People with Type 2 Diabetes: A Single Center, Cross-Sectional Study

Jannat

Sheikh

Tamanna

et al. 2023

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Objective: The aim of the study was to investigate whether oxidative stress resulting from enhanced free-radical formation, inflammation and higher total oxidation status plays a role in the initiation, progression and pathology of type 2 diabetes (T2D). Materials and methods: A total of 207 participants were enrolled, which comprised of 157 T2D patients (experimental group), and 50 people without diabetes (control group). Any subject suffering from cardiovascular diseases, impaired renal or liver functions has been excluded. The activities of certain oxidase enzymes, total oxidative stress and inflammatory leukocyte markers were investigated and compared between the studied groups. Results: Of the patients, 29.3% had HbA1c level < 7% and 28.0% had FPG level ≤ 7 mmol/L. The NADPH oxidase and myeloperoxidase, both of which are major contributors to reactive oxygen species (ROS) production, showed significantly higher activities in patients than in controls (p < 0.0001 and p < 0.001 respectively). Malondialdehyde (MDA), one of the end products of lipid peroxidation, was significantly higher in the patients (p < 0.0001). The total oxidative stress that estimates the overall oxidation status, was also significantly higher in the patients. The inflammatory leukocyte markers including total white blood cell count, percentage of neutrophils, and the neutrophil to lymphocyte ratio (NLR) were significantly higher in the patients (p < 0.0001). Further, the NADPH oxidase activity showed significant positive correlations with MDA, and NLR in T2D patients. Conclusions: These findings suggest that excessive productions of ROS by the oxidase enzymes, NADPH oxidase and myeloperoxidase, cause increased oxidative stress which in turn led to cellular inflammatory responses in patients with T2D.

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Oxidase Enzyme Activities and Their Correlations with Antioxidative Stress Biomarkers in Patients with Acute Coronary Syndrome in Bangladesh

Cited by 4 publications

References 36 publications

Role of complete blood count, antioxidants, and total antioxidant capacity in the pathophysiology of acute coronary syndrome

Role of complete blood count, antioxidants, and total antioxidant capacity in the pathophysiology of acute coronary syndrome

Heart Attack: A Comparative Study of Kyrgyzstan and Indian Treatment Methods

Oxidative Stress and Inflammatory Leukocyte Markers in People with Type 2 Diabetes: A Single Center, Cross-Sectional Study

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