Oxidase-like manganese oxide nanoparticles: a mechanism of organic acids/aldehydes as electron acceptors and potential application in cancer therapy

Pan, Yang; Zhang, Zhuangzhuang; Cun, Ju-E; Fan, Xi; Pan, Qingqing; Gao, Wenxia; Luo, Kui; He, Bin; Pu, Yuji

doi:10.1039/d3nr05127g

Nanoscale

2024

DOI: 10.1039/d3nr05127g

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Oxidase-like manganese oxide nanoparticles: a mechanism of organic acids/aldehydes as electron acceptors and potential application in cancer therapy

Yang Pan,

Zhuangzhuang Zhang,

Ju-E Cun

et al.

Abstract: Identifying the underlying catalytic mechanisms of synthetic nanocatalysts or nanozymes is important in directing their design and applications. Herein, we revisited the oxidation process of 4,4'-diamino-3,3',5,5'-tetramethylbiphenyl (TMB) by Mn3O4 nanoparticles...

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DNA Probing of Peroxidase‐Mimetic Activities of Selected Manganese‐Based Nanozymes and Measurement of Antioxidant Activity for DNA Protection

Salim Al‐Lami,

Demirci‐Çekiç,

Apak

2024

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Three different Mn‐based peroxidase‐mimetic nanoparticles (NPs) were synthesized as nanozymes: (i) manganese (II)‐ferrite (MnFe2O4) fabricated by co‐precipitating MnCl2.4H2O and FeCl3.6H2O; (ii) MnO2 synthesized from precipitation of MnSO4 in basic medium; (iii) manganese oxide obtained by reducing KMnO4 with tris(2‐hydroxyethyl) amine, all characterized using STEM, EDXS, FTIR and XPS techniques. These NPs acted as peroxidases, revealed by using a DNA probe, on which the damage generated by peroxidase mimetic NPs was monitored spectrophotometrically by CUPRAC and 3,3′,5,5′‐tetramethylbenzidine (TMB) methods. Results were confirmed by RP‐HPLC and voltammetry, the latter involving an AuNPs‐modified glassy carbon electrode (GCE), multi‐walled carbon nanotubes (MWCNT) and Nafion combination. Colorimetric assay with CUPRAC rather than TMB better agreed with chromatographic/voltammetric findings in detecting both peroxidase activity and DNA hazard. Mn(III)‐containing manganese oxide from permanganate reduction had stronger peroxidase activity. The proposed method demonstrated protective effects of antioxidants (morin, catechin and quercetin) against oxidative DNA damage for the first time.

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DNA Probing of Peroxidase‐Mimetic Activities of Selected Manganese‐Based Nanozymes and Measurement of Antioxidant Activity for DNA Protection

Salim Al‐Lami,

Demirci‐Çekiç,

Apak

2024

ChemistrySelect

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show abstract

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Oxidase-like manganese oxide nanoparticles: a mechanism of organic acids/aldehydes as electron acceptors and potential application in cancer therapy

Abstract: Identifying the underlying catalytic mechanisms of synthetic nanocatalysts or nanozymes is important in directing their design and applications. Herein, we revisited the oxidation process of 4,4'-diamino-3,3',5,5'-tetramethylbiphenyl (TMB) by Mn3O4 nanoparticles...

Cited by 1 publication

References 34 publications

DNA Probing of Peroxidase‐Mimetic Activities of Selected Manganese‐Based Nanozymes and Measurement of Antioxidant Activity for DNA Protection

DNA Probing of Peroxidase‐Mimetic Activities of Selected Manganese‐Based Nanozymes and Measurement of Antioxidant Activity for DNA Protection

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