Oxidation in Ultrahigh Molecular Weight Polyethylene and Cross-Linked Polyethylene Acetabular Cups Tested against Roughened Femoral Heads in a Hip Joint Simulator

Taddei, Paola; Affatato, Saverio; Fagnano, C.; Toni, Aldo

doi:10.1021/bm060007u

Cited by 42 publications

(39 citation statements)

References 63 publications

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“…Even though UHMWPE oxidation has been described by several groups [3,4,9,12] we originally reported that the oxidize alkane polymers, within 10 to 16 carbon atoms are by far more immunogenic in TLR1/2 stimulation that the non oxidize counterpart [5]. Herein we complement the previous data with further experiments indicating that TLR1/2 engagement induces a pro-inflammatory transcription program mediated by NFkB signaling pathways, inducing the expression of pro-IL-1β and pro-IL-18.…”

Section: Discussionmentioning

confidence: 99%

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

Maitra

Clement

Scharf

et al. 2009

Molecular Immunology

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Ultra high molecular weight polyethylene is widely used as a bearing surface in prosthetic arthroplasty. Over time the generation of implant-derived wear particles can initiate an inflammatory reaction characterized by periprosthetic inflammation and ultimately bone resorption at the prosthetic bone interface. Herein we present evidence that the different sized particles as well as the different length alkane polymers generated by implant wear leads to a two component inflammatory response. Polymeric alkane structures, with side chain oxidations, directly bind and activate the TLR-1/2 signaling pathway. Whereas micron and nanometer sized particulate debris are extensively phagocyted and induce enlargement, fusion and disruption of endosomal compartments. The resulting lysosomal damage and subsequent enzymatic leakage induces the NALP3 inflammasome activation as determined by cathepsins S and B cytosolic release, Caspase 1 activation and processing of pro-IL-1β, and pro-IL-18. These two processes synergistically results in the initiation of a strong inflammatory response with consequent cellular necrosis and extra-cellular matrix degradation.

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Section: Discussionmentioning

confidence: 99%

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

Maitra

Clement

Scharf

et al. 2009

Molecular Immunology

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“…The general recommended application temperature for PP products is below 80°C. On the other hand, the polymer network is known to increase product mechanical strength, temperature stability, and resistance to solvents, creep, and stress-cracking [24][25][26][27][28]. Cross linked polyethylene (x-PE) is used everywhere today in water piping and high voltage electrical cables [29].…”

Section: Introductionmentioning

confidence: 99%

Developing Polypropylene Bonded Hindered Phenol Antioxidants for Expanding Polypropylene Applications in High Temperature Conditions

Zhang¹,

C²,

Tc³

2017

J Material Sci Eng

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Polypropylene (PP) represents about a quarter of commercial plastics produced around the world. Despite its huge commercial success, PP polymer is not suitable for the applications that require long-term exposure to high temperatures (>80°C), due to its chemical and physical stability. The PP chain is prone to the oxidative chaindegradation and exhibits a relatively low material softening temperature. This paper discusses a new research approach by developing the PP-bonded hindered phenol (PP-HP) antioxidants to address this scientifically challenging issue. We have investigated two PP-HP structures, one with two methylene units adjacent to the hindered phenol group (HP-L) and one without this spacer (HP-S). In general, PP-HP polymers are advantaged with the ability to incorporate a suitable concentration of HP antioxidant groups with homogeneous distribution along the polymer chain, which provide effective protection to the PP chains from oxidative degradation. In addition, the specific PP-HP-L structure can also engage in a facile crosslinking reaction to form a 3-D network during the oxidation reaction. In one accelerated oxidation test in air at 190-210°C, the regular commercial PP polymer (containing common antioxidants and stabilizers) degrades within a few minutes; a PP-HP-L copolymer with about 1 mol% HP-L group shows almost no detectable weight loss after 24 hrs. In an ASTM endurance test at 140°C in air, the commercial PP shows 1% weight loss within about 10 days. On the other hand, the PP-HP-L polymer lasts for more than 30 years. Overall, the experiment results present the potential of expanding PP applications into a much higher temperature range (>140°C) under oxygen oxidative environments.

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“…Unfortunately, studies have often shown that some mechanical properties (impact toughness in particular) are compromised [3][4][5][6][7][8]. Current research efforts are being directed towards reducing the wear rate of UHMWPE without sacrificing the impact toughness typically associated with crosslinking.…”

Section: Introductionmentioning

confidence: 99%

Improved wear resistance of orthopaedic UHMWPE by reinforcement with zirconium particles

Plumlee

Schwartz

2009

Wear

122

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Oxidation in Ultrahigh Molecular Weight Polyethylene and Cross-Linked Polyethylene Acetabular Cups Tested against Roughened Femoral Heads in a Hip Joint Simulator

Cited by 42 publications

References 63 publications

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

Endosomal damage and TLR2 mediated inflammasome activation by alkane particles in the generation of aseptic osteolysis

Developing Polypropylene Bonded Hindered Phenol Antioxidants for Expanding Polypropylene Applications in High Temperature Conditions

Improved wear resistance of orthopaedic UHMWPE by reinforcement with zirconium particles

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