Oxidation of 5-Bromo- and 5-Fluoro-1,3-dimethyluracils by Peroxomono- and Peroxodisulfate Ions

Abstract

Oxidation of 5-bromo-1,3-dimethyluracil by KHSO5 gave 5,5-dibromo-6-hydroxy- and 5,5,6-trihydroxy-1,3-dimethyl-5,6-dihydrouracils and that of 5-fluoro-1,3-dimethyluracil by Na2S2O8 gave a 6,6′-dimeric product.

Oxidative Nucleobase Modifications Leading to Strand Scission

“…This is curious since deamination is usually thought to result from attack by nucleophiles at C6, followed by hydrolysis of the amidinium group. − With HSO 5 - , the N -oxide of C is formed at N3 . Substituted pyrimidines have also been studied to some extent. ,, …”

A kinetic and mechanistic study on the oxidation of indole‐3‐acetic acid by peroxodisulfate

“…Studies on the oxidation of organic compounds and inorganic complexes by peroxodisulfate have been reported 1–11. Oxidation of indoles has received much attention due to the involvement of their resulting products in significant biological processes 12.…”