Oxidation of Alcohols and Aldehydes with Peracetic Acid and a Mn(II)/Pyridin‐2‐Carboxylato Catalyst: Substrate and Continuous Flow Studies

Ryan, Ailbhe A.; Dempsey, Seán D.; Smyth, Megan; Fahey, Karen; Moody, Thomas S.; Wharry, Scott; Dingwall, Paul; Rooney, David W.; Thompson, Jillian M.; Knipe, Peter C.; Muldoon, Mark J.

doi:10.1002/cctc.202301709

ChemCatChem

2024

DOI: 10.1002/cctc.202301709

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Oxidation of Alcohols and Aldehydes with Peracetic Acid and a Mn(II)/Pyridin‐2‐Carboxylato Catalyst: Substrate and Continuous Flow Studies

Ailbhe A. Ryan,

Seán D. Dempsey,

Megan Smyth

et al.

Abstract: A homogeneous catalyst system, consisting of Mn(OAc)2 and 2‑picolinic acid was studied for alcohol oxidation using peracetic acid as the oxidant. Catalyst loadings as low as 0.01 mol% could be utilized and the system compared well to other peroxide based methods. The utilization of continuous flow allowed the fast, exothermic reactions to be carried out in a safe and scalable manner.

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Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air

Bannon,

Morrison,

Smyth

et al. 2024

Org. Process Res. Dev.

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A continuous flow approach for the aerobic photo-oxidation of benzylic substrates to ketone and aldehyde products is presented. The resulting process exploits UV-A LEDs (375 nm) in combination with a Corning AFR reactor that ensures effective gas−liquid mixing and leads to short residence times of 1 min. A variety of benzylic substrates are converted to their corresponding carbonyl products, and scalability is demonstrated to produce multigram quantities of products within a few hours. Overall, this continuous flow approach offers several improvements over alternative oxidation methods due to the combined use of air as an oxidant and SAS (sodium anthraquinone-2 sulfonate) as a water-soluble photocatalyst. The use of greener and safer conditions together with process intensification principles renders this flow approach attractive for further industrial applications.

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Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air

Bannon,

Morrison,

Smyth

et al. 2024

Org. Process Res. Dev.

Self Cite

View full text Add to dashboard Cite

show abstract

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Oxidation of Alcohols and Aldehydes with Peracetic Acid and a Mn(II)/Pyridin‐2‐Carboxylato Catalyst: Substrate and Continuous Flow Studies

Cited by 1 publication

References 62 publications

Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air

Continuous Flow Approach for Benzylic Photo-oxidations Using Compressed Air

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