Oxidation of Monosaccharides with Oxygen in Alkaline Solution. Separation, Identification and Estimation of the Aldonic Acids Produced by Liquid Chromatography^1,2

Erythrose and Threose: Carbonyl Migrations, Epimerizations, Aldol, and Oxidative Fragmentation Reactions under Plausible Prebiotic Conditions

“…This suggested pathway is consistent with the mechanistic pathway suggested by Dubourg and Naffa. [ 24 , 25 ]…”

“…This suggested pathway is consistent with the mechanistic pathway suggested by Dubourg and Naffa. [24,25] It was initially postulated that the source of formate was from the oxidation of formaldehyde derived from a retro-aldol reaction of tetrulose. In control experiments it was observed that formate was not detected when 13 C labeled formaldehyde was submitted to the identical reaction conditions applied to erythrose or threose at pH 8.5 thus eliminating formaldehyde as the formate precursor (Supporting Information Figure S13).…”