Oxidation of p-toluenesulfonylhydrazide to 1,2-di(p-toluenesulfonyl)hydrazine

Jacobs, Richard L.

doi:10.1021/jo00423a046

Cited by 9 publications

(7 citation statements)

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“…Cobalt catalysts are widely used in the oxidation of unsaturated compounds due to their activity with hydroperoxides 47–49. To expedite the onset of the third regime of oxidation, cobalt(II) ethyl hexanoate (65 wt % in mineral oil) was used as a catalyst in a 5 wt %/vol % mixture with raw soybean oil.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of triglyceride‐based polyols and tack‐free coatings via the air oxidation of soy oil

Fornof

Onah

Ghosh

et al. 2006

J of Applied Polymer Sci

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ABSTRACT:The effect of time and temperature on the air oxidation of soybean oil in the absence of catalysts or added initiators was investigated. It was possible to divide the air oxidation of soybean oil into three regimes. The first regime of air oxidation resulted in insignificant change in the hydroxyl number. During this regime, it was proposed that natural antioxidants, which are present in raw soybean oil, were consumed and peroxide formation occurred. A drastic increase in hydroxyl number due to the formation and subsequent decomposition of peroxides marked the second regime of air oxidation. In the third regime of air oxidation, free radical crosslinking of the soybean oil occurred, and an insoluble gel was formed. The three regimes of air oxidation were used as a guide for the preparation of soy-based polyols and crosslinked polymers. Crosslinked, tack-free coatings were prepared from a metal catalyzed oxidation of soybean oil, where soybean oil and ambient oxygen were the only reactants. Higher temperatures (125°C) were more efficient than lower (50°C) for obtaining high gel fractions and tack-free coatings. Cure of the coatings was expedited with exposure of the coating to UV irradiation after initial heating.

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Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of triglyceride‐based polyols and tack‐free coatings via the air oxidation of soy oil

Fornof

Onah

Ghosh

et al. 2006

J of Applied Polymer Sci

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“…It is also possible that a decreased phosphorylation on serine residues plays a role in the elevated basal activity and responsiveness of placental IGF-I receptors of diabetic rats. Previous studies have shown that the number of phosphorylated serine residues is greater in the /3 subunit of the IGF-I receptor than in the insulin receptor (Jacobs & Cuatrecasas, 1986), suggesting that additional kinases are involved in regulating IGF-I receptor function. Although several pieces of evidence support an impairment of protein kinase C activity in diabetes and other insulin-resistant states (Van de Werve et al, 1987;Okumura et al, 1988;Heydrick et al, 1991), diabetes-induced alterations in serine phosphorylation in diabetic placenta remain to be demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Functional alterations of type I insulin-like growth factor receptor in placenta of diabetic rats

Mouzon

Louizeau

Girard

1992

Biochemical Journal

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The presence of type I insulin-like growth factor (IGF-I) receptors on placental membranes led to the hypothesis that these receptors might play a critical role in the rapid growth of this organ. Diabetes induces feto-placental overgrowth, but it is not known whether it modifies IGF-I receptor activity in fetal and/or placental tissues. To answer this question, we have partially purified and characterized placental receptors from normal and streptozotocin-induced diabetic rats. In normal rats, binding of 125I-IGF-I to a 140 kDa protein corresponding to the alpha subunit of the receptor was observed in cross-linking experiments performed under reducing conditions. Stimulation by IGF-I induces the autophosphorylation of a 105 kDa phosphoprotein representing the beta subunit of the receptor. In rats made hyperglycaemic and insulinopenic by streptozotocin injection on day 1 of pregnancy, placental IGF-I receptor-binding parameters were not different from controls on day 20 of pregnancy. In contrast, the autophosphorylation and kinase activity of IGF-I receptors of diabetic rats were increased 2-3-fold in the basal state and after IGF-I stimulation. The present study indicates that the rat placental IGF-I receptor possesses structural characteristics similar to that reported for fetal-rat muscle, and suggests that the high-molecular-mass beta subunit could represent a type of receptor specifically expressed during prenatal development. In addition, it clearly demonstrates that diabetes induces functional alterations in IGF-I receptor kinase activity that may play a major role in the placental overgrowth in diabetic pregnancy.

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“…This threonine residue is conserved in HER2/neu (Thr 685) (Coussens et al, 1985), and an identically situated serine residue, also flanked by basic residues, is the target of protein kinase C in pp60v-src (Gould et al, 1985). Although it has not yet been demonstrated that IGF-I or insulin receptors are protein kinase C substrates, both receptors are phosphorylated predominantly on serine residues when intact cells are treated with phorbol esters, known activators of protein kinase C (Jacobs et al, 1983c;Takayama et al, 1984;Jacobs and Cuatrecasas, 1986). It is thus noteworthy that the IGF-I receptor has a serine residue (935), flanked by basic residues, that is located near the membrane-spanning domain and could serve as a protein kinase C target.…”

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

Ullrich¹,

Gray²,

Tam³

et al. 1986

The EMBO Journal

1,748

883

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To identify structural characteristics of the closely related cell surface receptors for insulin and IGF‐I that define their distinct physiological roles, we determined the complete primary structure of the human IGF‐I receptor from cloned cDNA. The deduced sequence predicts a 1367 amino acid receptor precursor, including a 30‐residue signal peptide, which is removed during translocation of the nascent polypeptide chain. The 1337 residue, unmodified proreceptor polypeptide has a predicted Mr of 151,869, which compares with the 180,000 Mr IGF‐I receptor precursor. In analogy with the 152,784 Mr insulin receptor precursor, cleavage of the Arg‐Lys‐Arg‐Arg sequence at position 707 of the IGF‐I receptor precursor will generate alpha (80,423 Mr) and beta (70,866 Mr) subunits, which compare with approximately 135,000 Mr (alpha) and 90,000 Mr (beta) fully glycosylated subunits.

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Oxidation of p-toluenesulfonylhydrazide to 1,2-di(p-toluenesulfonyl)hydrazine

Cited by 9 publications

References 0 publications

Synthesis and characterization of triglyceride‐based polyols and tack‐free coatings via the air oxidation of soy oil

Synthesis and characterization of triglyceride‐based polyols and tack‐free coatings via the air oxidation of soy oil

Functional alterations of type I insulin-like growth factor receptor in placenta of diabetic rats

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

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