Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging

Vedamalai, Mani; Kedaria, Dhaval; Vasita, Rajesh; Gupta, Iti

doi:10.1016/j.snb.2018.02.071

Cited by 57 publications

(12 citation statements)

References 23 publications

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“…As has been well shown in previous studies, [43][44][45] the electron rich sulde was easily oxidized to sulfoxide by HOCl. To elucidate the detailed signal mechanism, the "turn-off" uorescence sensing mechanism for Probe 1 toward HOCl was proposed in Scheme 2.…”

Section: Proposed Reaction Mechanism and Nmr Analysissupporting

confidence: 79%

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

Jiao

Liu

et al. 2019

RSC Adv.

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Section: Proposed Reaction Mechanism and Nmr Analysissupporting

confidence: 79%

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

Jiao

Liu

et al. 2019

RSC Adv.

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“…BODIPY dyes are very prominent chromophores due to their excellent photophysical properties such as good absorption and emission in the visible range; 39 as such, they have been widely used in biological labels, 40 fluorescent switches and sensors, 41,42 and anti-cancer agents in PDT. 43 Herein, the photophysical properties of the BODIPY-fullerene-based dyads were studied by using UV-vis absorption and fluorescence emission spectroscopies.…”

Section: Resultsmentioning

confidence: 99%

Effects of regioisomeric BODIPY-C₆₀bis-cycloadducts on the generation of singlet oxygen

Gündüz

Okutan

2022

New J. Chem.

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“…Relatively, fluorescent probes for determining cellular hypochlorite contents are rare [18][19][20]. The sensing mechanism behind these probes mainly relies on the strong oxidation property of hypochlorite.…”

Section: Introductionmentioning

confidence: 99%

Development of Fluorescent Carbon Nanoparticle-Based Probes for Intracellular pH and Hypochlorite Sensing

et al. 2022

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Acid-base and redox reactions are important mechanisms that affect the optical properties of fluorescent probes. Fluorescent carbon nanoparticles (CNPs) that possess tailored surface functionality enable a prompt response to regional stimuli, offering a useful platform for detection, sensing, and imaging. In this study, mPA CNPs were developed through one-pot hydrothermal reaction as a novel fluorescent probe (quantum yield = 10%) for pH and hypochlorite sensing. m-Phenylenediamine was chosen as the major component of CNPs for pH and hypochlorite responsiveness. Meanwhile, ascorbic acid with many oxygen-containing groups was introduced to generate favorable functionalities for improved water solubility and enhanced sensing response. Thus, the mPA CNPs could serve as a pH probe and a turn-off sensor toward hypochlorite at neutral pH through fluorescence change. The as-prepared mPA CNPs exhibited a linear fluorescence response over the pH ranges from pH 5.5 to 8.5 (R2 = 0.989), and over the concentration range of 0.125–1.25 μM for hypochlorite (R2 = 0.985). The detection limit (LOD) of hypochlorite was calculated to be 0.029 μM at neutral pH. The mPA CNPs were further applied to the cell imaging. The positively charged surface and nanoscale dimension of the mPA CNPs lead to their efficient intracellular delivery. The mPA CNPs were also successfully used for cell imaging and sensitive detection of hypochlorite as well as pH changes in biological systems. Given these desirable performances, the as-synthesized fluorescent mPA CNPs shows great potential as an optical probe for real-time pH and hypochlorite monitoring in living cells.

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Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging

Cited by 57 publications

References 23 publications

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

Effects of regioisomeric BODIPY-C₆₀bis-cycloadducts on the generation of singlet oxygen

Development of Fluorescent Carbon Nanoparticle-Based Probes for Intracellular pH and Hypochlorite Sensing

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Oxidation of phenothiazine based fluorescent probe for hypochlorite and its application to live cell imaging

Cited by 57 publications

References 23 publications

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

A simple sensor based on 1,8-naphthalimide with large Stokes shift for detection of hypochlorous acid in living cells

Effects of regioisomeric BODIPY-C60bis-cycloadducts on the generation of singlet oxygen

Development of Fluorescent Carbon Nanoparticle-Based Probes for Intracellular pH and Hypochlorite Sensing

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Effects of regioisomeric BODIPY-C₆₀bis-cycloadducts on the generation of singlet oxygen