Oxidation of terpenoid diols with chlorine dioxide: Preparation of ketols and α-chlorohydroxyketones of carane and pinane structures

Фролова, Л. Л.; Попов, А. В.; Bezuglaya, L. V.; Alekseev, I. N.; Слепухин, П. А.; Кучин, А. В.

doi:10.1134/s1070363213080124

Cited by 5 publications

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“…[16] Chlorin terpene derivatives (3-7) were obtained by interaction of the activated carboxyl group of terpene acids with aminochlorin. The initial acids were: myrtenic, [17] 3,3-dimethylbicyclo[2.2.1]heptane-2-carboxylic, [18] cis-pinonic, [19] cis-pinononic, [19] and 2,2-dimethyl-3-(2-oxopropyl)cyclopropyl acetic acids [20] (Figure 1). Activation of the carboxyl groups of the terpenic acids was done using DCC.…”

Section: Resultsmentioning

confidence: 99%

New Сhlorin-Terpene Conjugates: Synthesis, Photoinduced and Dark Cytotoxicity

Mal’shakova¹,

Pylina²,

Фролова³

et al. 2016

MHC

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The concentrations, at which chlorin-myrtenic (3) and chlorin-camphenylanic (4) conjugates exhibit photoinduced cytotoxicity, differ by more than two orders of magnitude from the concentrations at which these compounds show dark cytotoxicity. In comparison, the difference between the active concentrations under the light and in-the-dark for Photolon is approximately one order of magnitude. This allows to suggest a high potential of the new compounds 3 and 4 for further in vitro and in vivo studies to eventually improve the efficiency and safety of photodynamic therapy of cancer.Keywords: Chlorin e 6 , terpene acids, chlorin-terpene conjugates, dicyclohexylcarbodiimide (DCC), photosensitizers.Новые хлорин -терпеновые конъюгаты: синтез, фотоиндуцированная и темновая цитотоксичность

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